BIS(2,4-DIMETHOXYBENZYL)AMINE
- Product Name
- BIS(2,4-DIMETHOXYBENZYL)AMINE
- CAS No.
- 20781-23-1
- Chemical Name
- BIS(2,4-DIMETHOXYBENZYL)AMINE
- Synonyms
- Einecs 244-037-2;Bis(2,4-dimethoxybenzyl);Bis(2,4-dimethoxybenyl)amine;BIS(2,4-DIMETHOXYBENZYL)AMINE;Bis(2,4-dimenthoxybenzyl)amine;2,2',4,4'TETRAMETHOXYDIBENZYLAMINE;bis[(2,4-diMethoxyphenyl)Methyl]aMine;Benzenemethanamine, N-(2,4-dimethoxyphenyl)methyl-2,4-dimethoxy-;1-(2,4-DIMETHOXYPHENYL)-N-[(2,4-DIMETHOXYPHENYL)METHYL]METHANAMINE
- CBNumber
- CB6436463
- Molecular Formula
- C18H23NO4
- Formula Weight
- 317.38
- MOL File
- 20781-23-1.mol
BIS(2,4-DIMETHOXYBENZYL)AMINE Property
- Boiling point:
- 443.5±40.0 °C(Predicted)
- Density
- 1.102±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 7.90±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C18H23NO4/c1-20-15-7-5-13(17(9-15)22-3)11-19-12-14-6-8-16(21-2)10-18(14)23-4/h5-10,19H,11-12H2,1-4H3
- InChIKey
- IZWMZVDEYOKQCG-UHFFFAOYSA-N
- SMILES
- C1(CNCC2=CC=C(OC)C=C2OC)=CC=C(OC)C=C1OC
Safety
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D472508
- Product name
- Bis(2,4-Dimethoxybenzyl)amine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 079530
- Product name
- Bis(2,4-dimethoxybenzyl)amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- FB140645
- Product name
- Bis(2,4-dimethoxybenzyl)amine
- Packaging
- 2g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- BP-21309
- Product name
- BIS(2,4-DIMETHOXYBENZYL)AMINE
- Purity
- 95%
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
- Product number
- 076214
- Product name
- Bis(2,4-dimethoxybenzyl)amine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
BIS(2,4-DIMETHOXYBENZYL)AMINE Chemical Properties,Usage,Production
Uses
Bis(2,4-Dimethoxybenzyl)amine is used in the preparation of TLR8 agonists.
Synthesis
20781-20-8
613-45-6
20781-23-1
At room temperature, 2,4-dimethoxybenzaldehyde (Sigma Aldrich; 1.1 g, 6.61 mmol) was dissolved in 20 mL of tetrahydrofuran (THF). To this solution 2,4-dimethoxybenzylamine (Sigma Aldrich; 1.5 mL, 9.98 mmol) was added dropwise, followed by sodium triacetoxyborohydride (Sigma Aldrich; 17 g; 80.4 mmol). The reaction mixture gradually became turbid and the reaction was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was diluted with saturated sodium bicarbonate (NaHCO3) solution and subsequently extracted with ethyl acetate (EtOAc). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (using a 40 g ISCO column with an elution gradient of 0 to 100% ethyl acetate/hexane) to afford bis(2,4-dimethoxybenzyl)amine (2.08 g, 6.55 mmol, 99% yield, 96% purity).
References
[1] Patent: WO2017/147410, 2017, A1. Location in patent: Page/Page column 1832
[2] Tetrahedron Letters, 2010, vol. 51, # 28, p. 3645 - 3648
[3] Chemische Berichte, 1968, vol. 101, # 10, p. 3623 - 3641
[4] Patent: US2013/131050, 2013, A1. Location in patent: Paragraph 0570; 0571
[5] Patent: WO2018/97945, 2018, A1. Location in patent: Paragraph 0395
BIS(2,4-DIMETHOXYBENZYL)AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BIS(2,4-DIMETHOXYBENZYL)AMINE manufacturers
- Product
- BIS(2,4-DIMETHOXYBENZYL)AMINE 20781-23-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 2000
- Release date
- 2025-09-03
- Product
- BIS(2,4-DIMETHOXYBENZYL)AMINE 20781-23-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- BIS(2,4-DIMETHOXYBENZYL)AMINE 20781-23-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-30