ChemicalBook > CAS DataBase List > BIS(2,4-DIMETHOXYBENZYL)AMINE

BIS(2,4-DIMETHOXYBENZYL)AMINE

Product Name
BIS(2,4-DIMETHOXYBENZYL)AMINE
CAS No.
20781-23-1
Chemical Name
BIS(2,4-DIMETHOXYBENZYL)AMINE
Synonyms
Einecs 244-037-2;Bis(2,4-dimethoxybenzyl);Bis(2,4-dimethoxybenyl)amine;BIS(2,4-DIMETHOXYBENZYL)AMINE;Bis(2,4-dimenthoxybenzyl)amine;2,2',4,4'TETRAMETHOXYDIBENZYLAMINE;bis[(2,4-diMethoxyphenyl)Methyl]aMine;Benzenemethanamine, N-(2,4-dimethoxyphenyl)methyl-2,4-dimethoxy-;1-(2,4-DIMETHOXYPHENYL)-N-[(2,4-DIMETHOXYPHENYL)METHYL]METHANAMINE
CBNumber
CB6436463
Molecular Formula
C18H23NO4
Formula Weight
317.38
MOL File
20781-23-1.mol
More
Less

BIS(2,4-DIMETHOXYBENZYL)AMINE Property

Boiling point:
443.5±40.0 °C(Predicted)
Density 
1.102±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
7.90±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C18H23NO4/c1-20-15-7-5-13(17(9-15)22-3)11-19-12-14-6-8-16(21-2)10-18(14)23-4/h5-10,19H,11-12H2,1-4H3
InChIKey
IZWMZVDEYOKQCG-UHFFFAOYSA-N
SMILES
C1(CNCC2=CC=C(OC)C=C2OC)=CC=C(OC)C=C1OC
More
Less

Safety

HS Code 
2922290090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

TRC
Product number
D472508
Product name
Bis(2,4-Dimethoxybenzyl)amine
Packaging
50mg
Price
$60
Updated
2021/12/16
Oakwood
Product number
079530
Product name
Bis(2,4-dimethoxybenzyl)amine
Purity
95%
Packaging
1g
Price
$54
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140645
Product name
Bis(2,4-dimethoxybenzyl)amine
Packaging
2g
Price
$81
Updated
2021/12/16
BroadPharm
Product number
BP-21309
Product name
BIS(2,4-DIMETHOXYBENZYL)AMINE
Purity
95%
Packaging
1g
Price
$99
Updated
2021/12/16
Matrix Scientific
Product number
076214
Product name
Bis(2,4-dimethoxybenzyl)amine
Purity
95+%
Packaging
1g
Price
$152
Updated
2021/12/16
More
Less

BIS(2,4-DIMETHOXYBENZYL)AMINE Chemical Properties,Usage,Production

Uses

Bis(2,4-Dimethoxybenzyl)amine is used in the preparation of TLR8 agonists.

Synthesis

20781-20-8

613-45-6

20781-23-1

At room temperature, 2,4-dimethoxybenzaldehyde (Sigma Aldrich; 1.1 g, 6.61 mmol) was dissolved in 20 mL of tetrahydrofuran (THF). To this solution 2,4-dimethoxybenzylamine (Sigma Aldrich; 1.5 mL, 9.98 mmol) was added dropwise, followed by sodium triacetoxyborohydride (Sigma Aldrich; 17 g; 80.4 mmol). The reaction mixture gradually became turbid and the reaction was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was diluted with saturated sodium bicarbonate (NaHCO3) solution and subsequently extracted with ethyl acetate (EtOAc). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (using a 40 g ISCO column with an elution gradient of 0 to 100% ethyl acetate/hexane) to afford bis(2,4-dimethoxybenzyl)amine (2.08 g, 6.55 mmol, 99% yield, 96% purity).

References

[1] Patent: WO2017/147410, 2017, A1. Location in patent: Page/Page column 1832
[2] Tetrahedron Letters, 2010, vol. 51, # 28, p. 3645 - 3648
[3] Chemische Berichte, 1968, vol. 101, # 10, p. 3623 - 3641
[4] Patent: US2013/131050, 2013, A1. Location in patent: Paragraph 0570; 0571
[5] Patent: WO2018/97945, 2018, A1. Location in patent: Paragraph 0395

BIS(2,4-DIMETHOXYBENZYL)AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BIS(2,4-DIMETHOXYBENZYL)AMINE Suppliers

China 108 Germany 2 India 1 United Kingdom 3 United States 11 Global 125
Wuhan Luohua Medical Technology Co.,Ltd.
Tel
13477084141; 13477084141
Fax
+86(27)65566697
Email
sales@luohuapharm.com
Country
China
ProdList
468
Advantage
60
Weifang Clarite Pharmaceutical Technology Co., Ltd
Tel
18105366931
Email
creatpharm@163.com
Country
China
ProdList
485
Advantage
58
Henan Aosman Biotechnology Co., LTD
Tel
0371-0371-61318675 17719817155
Fax
0371-61318675
Email
sales@xlinebio.com
Country
China
ProdList
2857
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
TRL Bioscience Co., Ltd.
Tel
021-54822871 13817743194
Fax
021-54827552
Email
info@shtrl.com
Country
China
ProdList
93
Advantage
62
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Sci General Material & Chemical Ltd
Tel
021-58388037;21-58388037 13472507714
Email
35177634@qq.com;1589045147@qq.com
Country
China
ProdList
803
Advantage
55
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Aloespharm Co., Ltd.
Tel
021-20960837
Fax
021-20960837
Email
market@aloespharm.com
Country
China
ProdList
1302
Advantage
55
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1839
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9986
Advantage
58
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1707
Advantage
55
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Yancheng KangdiSen Pharmaceutical Co., Ltd.
Tel
13812573443
Fax
-
Email
tongbenwan22@163.com
Country
China
ProdList
1980
Advantage
55
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9981
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10267
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai Scochem Technology Co., Ltd.
Tel
021-33758897
Email
sales@scochem.com
Country
China
ProdList
1596
Advantage
58
Shanghai UCHEM Inc.
Tel
+862156762820 +86-13564624040
Email
sales@myuchem.com
Country
China
ProdList
8460
Advantage
58
Nanjing Hengbei Chemicals Co., Ltd.
Tel
+86-25-58393656
Fax
+86-25-58393656
Email
sales@hengbeichem.cn
Country
China
ProdList
6854
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Blocksynth Pharmaceutical Technology Co.,Ltd
Tel
0086-19817745290; +8619817745290
Email
bd@blocksynth.com
Country
China
ProdList
5661
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
More
Less

View Lastest Price from BIS(2,4-DIMETHOXYBENZYL)AMINE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
BIS(2,4-DIMETHOXYBENZYL)AMINE 20781-23-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
2000
Release date
2025-09-03
Henan Aochuang Chemical Co.,Ltd.
Product
BIS(2,4-DIMETHOXYBENZYL)AMINE 20781-23-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Career Henan Chemical Co
Product
BIS(2,4-DIMETHOXYBENZYL)AMINE 20781-23-1
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-30

20781-23-1, BIS(2,4-DIMETHOXYBENZYL)AMINERelated Search:

N,N-bis(3,4-dimethoxybenzyl)amine 2,4-Dimethoxybenzylamine BIS(2,4-DIMETHOXYBENZYL)AMINE 2-(BENZYLAMINO-METHYL)-PHENOLHYDROCHLORIDE OTAVA-BB 1400606 N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE BENZYL-(2-METHOXY-BENZYL)-AMINE 4-HYDROXY-2-METHOXYBENZYLAMINE 2-HYDROXY-4-METHOXYBENZYLAMINE BENZYL-(2,4-DIMETHOXY-BENZYL)-AMINE CHEMBRDG-BB 5543423 2-METHOXY-N-METHYLBENZYLAMINE 97 benzyl[(4-methoxyphenyl)methyl]amine 2,4-dihydroxybenzylamine N-ETHYL-O-METHOXYBENZYLAMINE

  • BIS(2,4-DIMETHOXYBENZYL)AMINE
  • 2,2',4,4'TETRAMETHOXYDIBENZYLAMINE
  • Benzenemethanamine, N-(2,4-dimethoxyphenyl)methyl-2,4-dimethoxy-
  • Einecs 244-037-2
  • Bis(2,4-dimethoxybenyl)amine
  • Bis(2,4-dimenthoxybenzyl)amine
  • bis[(2,4-diMethoxyphenyl)Methyl]aMine
  • Bis(2,4-dimethoxybenzyl)
  • 1-(2,4-DIMETHOXYPHENYL)-N-[(2,4-DIMETHOXYPHENYL)METHYL]METHANAMINE
  • 20781-23-1
  • C18H23NO4