N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE
- Product Name
- N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE
- CAS No.
- 102503-23-1
- Chemical Name
- N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE
- Synonyms
- 1-(2,4-DiMethoxyphenyl)-N-MethylMethanaMine;2,4-Dimethoxy-N-methylbenzylamine;AKOS BC-0898;1-(2,4-Dimethoxyphenyl);(2,4-DiMethoxybenzyl)MethylaMine;N-Methyl-2,4-Dimethoxybenzylamine;-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE;N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE;Benzenemethanamine, 2,4-dimethoxy-N-methyl-;(2,4-diMethoxyphenyl)-N-MethylMethanaMiniuM
- CBNumber
- CB3372588
- Molecular Formula
- C10H15NO2
- Formula Weight
- 181.23
- MOL File
- 102503-23-1.mol
N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE Property
- Boiling point:
- 262.1±25.0 °C(Predicted)
- Density
- 1.012±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 9.32±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C10H15NO2/c1-11-7-8-4-5-9(12-2)6-10(8)13-3/h4-6,11H,7H2,1-3H3
- InChIKey
- ULVUWTHGZHDWMW-UHFFFAOYSA-N
- SMILES
- C1(CNC)=CC=C(OC)C=C1OC
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D481025
- Product name
- 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD142242
- Product name
- 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine
- Packaging
- 1g
- Price
- $218.75
- Updated
- 2021/12/16
- Product number
- FD142242
- Product name
- 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine
- Packaging
- 2g
- Price
- $372
- Updated
- 2021/12/16
- Product number
- 119650
- Product name
- 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- OR945146
- Product name
- (2,4-Dimethoxybenzyl)methylamine
- Purity
- 97%
- Packaging
- 5g
- Price
- $538
- Updated
- 2021/12/16
N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE Chemical Properties,Usage,Production
Synthesis
613-45-6
74-89-5
102503-23-1
To a stirred solution of 2,4-dimethoxybenzaldehyde (20.0 g, 120.48 mmol) in methanol (200 mL), a methanolic solution of methylamine (33%, 15.0 g, 481.90 mmol) was slowly added at 0°C and the reaction mixture was kept stirring at 0°C for 1 hour. Subsequently, sodium borohydride (5.5 g, 144.57 mmol) was added in batches at 0 °C and the reaction mixture was kept stirring at room temperature for 12 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was acidified with dilute hydrochloric acid (200 mL) and methanol was removed by distillation under reduced pressure. The residue was diluted with water and alkalized with dilute sodium hydroxide solution (80 mL). The aqueous layer was extracted with ethyl acetate (5 x 200 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (50-80% ethyl acetate/hexane gradient elution) to afford 2,4-dimethoxy-N-methylbenzenemethanamine (20.0 g, 92.0% yield) as a light yellow liquid.1H NMR (400 MHz, DMSO-d6): δ 7.14 (d, J = 8.4Hz, 1H), 6.51 (brs, 1H), 6.47-6.45 (d, J = 8.4Hz, 1H), 6.47-6.45 (brs, 1H). 6.47-6.45 (m, 1H), 3.74 (s, 6H), 3.53 (s, 2H), 2.24 (s, 3H); LC-MS: m/z 181.80 [M + H]+.
References
[1] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 301
[2] Patent: WO2008/108380, 2008, A2. Location in patent: Page/Page column 103-104
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 2, p. 378 - 381
N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE Suppliers
- Tel
- 0512-63263366 18912765016
- Fax
- 0512-6326 3366
- tongtf110@sina.com
- Country
- China
- ProdList
- 993
- Advantage
- 62
- Tel
- 181-3307-5798 18017383231
- 983544897@qq.com
- Country
- China
- ProdList
- 921
- Advantage
- 58
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3763
- Advantage
- 58
- Tel
- 028-85114309 18982182443
- yangli@happysyn.com
- Country
- China
- ProdList
- 2150
- Advantage
- 55
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 0371-88888888 272369594
- Fax
- QQ:272369594
- 2723695949@qq.com
- Country
- China
- ProdList
- 4958
- Advantage
- 50
View Lastest Price from N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE manufacturers
- Product
- N-(2,4-DIMETHOXYBENZYL)-N-METHYLAMINE 102503-23-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01