U-46619

Product Name: U-46619
CAS No.: 56985-40-1
Chemical Name: U-46619
Synonyms: U-46619;U 46619,U46619;9,11-Methanoxy-PGH2;11-Methanoepoxy PGH2;9,11-Methanoepoxy PGH2;U46619, U-46619, U 46619;11α,9α-Epoxymethanoprostaglandin H2;U-46619 - CAS 56985-40-1 - Calbiochem;9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO;U-46619, Thromboxane A2 receptor agonist
CBNumber: CB6437516
Molecular Formula: C21H34O4
Formula Weight: 350.49
MOL File: 56985-40-1.mol

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U-46619 Property

Boiling point:: 519.7±30.0 °C(Predicted)
Density: 1.092±0.06 g/cm3(Predicted)
Flash point:: -10 °C
storage temp.: -20°C
solubility: ≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2
pka: 4.76±0.10(Predicted)
form: solution
color: Colorless to light yellow
BRN: 4267334

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Safety

Hazard Codes: F,Xi
Risk Statements: 11-36-66-67
Safety Statements: 16-26
RIDADR: UN 1231 3/PG 2
WGK Germany: 2
RTECS: MJ9681090
F: 8-10-23
Toxicity: LD50 intravenous in mouse: 66ug/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D8174
Product name: 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
Purity: solution, 10 mg/mL in methyl acetate
Packaging: 1mg
Price: $339
Updated: 2024/03/01

Sigma-Aldrich

Product number: 538944
Product name: U-46619
Packaging: 1mg
Price: $242
Updated: 2022/05/15

Cayman Chemical

Product number: 16450
Product name: U-46619
Purity: ≥98%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 16450
Product name: U-46619
Purity: ≥98%
Packaging: 5mg
Price: $437
Updated: 2024/03/01

Sigma-Aldrich

Product number: D8174
Product name: 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
Purity: solution, 10 mg/mL in methyl acetate
Packaging: 5mg
Price: $1330
Updated: 2024/03/01

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U-46619 Chemical Properties,Usage,Production

Uses

U 46619 is a PGH2 analog that may be used as a thromboxane A2 (TP) receptor agonist affecting mitogenic growth of vascular smooth muscle in humans.

Biological Activity

PGH 2 (TXA 2 ) analog that is a potent and stable thromboxane A 2 (TP) receptor agonist (EC 50 = 0.035 μ M). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK-293 cells expressing TP α and TP β receptors.

Biochem/physiol Actions

Thromboxane receptor agonist.

in vitro

u46619 showed a biphasic effect on human platelets. shape change and mlcp occurred at low concentrations of this compound (ec50 = 0.035 um and 0.057 um), whereas serotonin release, platelet at higher concentrations (ec50 = 0.536 um and 1.31 um). the effect on platelet shape change and mlcp is receptor mediated [3].

in vivo

u46619, through activation of eta and etb receptors, elicits renal cortical vasoconstriction and medullary vasodilation in the rat [2]. in conscious shr (spontaneously hypertensive rats), 1-100 nmol/kg u-46619 (i.c.v.) induced a dose-related increase in blood pressure but had no significant effect on heart rate [1].

storage

Store at -20°C

References

[1] sirén al, svartstrm-fraser m, paakkari i. central cardiovascular effects of the endoperoxide analogue u-46619 in rats. prostaglandins leukot med. 1985 mar; 17 (3): 381-6.
[2] hantz h, adesuyi a, adebayo o. differential effects of u46619 on renal regional hemodynamics in the rat: involvement of endothelin. j pharmacol exp ther. 2001 oct; 299 (1): 372-6.
[3] morinelli ta1, niewiarowski s, daniel jl, smith jb. receptor-mediated effects of a pgh2 analogue (u 46619) on human platelets. am j physiol. 1987 nov; 253 (5 pt 2): h1035-43.

U-46619 Preparation Products And Raw materials

Raw materials

Preparation Products

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U-46619 Suppliers

China 48 Germany 1 India 1 Japan 3 Switzerland 2 United Kingdom 2 United States 14 USA 1 Global 72

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56985-40-1, U-46619Related Search:

9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Bromadoline U 75875 METHYLENECYCLOHEXANE ETHYLENE OXIDE DELTA17-U-46619 5-TRANS U-46619 U-46619 [15-3H]- U-46619

9,11-DIDEOXY-11Α,9Α-EPOXYMETHANOPROSTAGLANDIN F2Α,SOLUTION

U-46619 - CAS 56985-40-1 - Calbiochem

9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO

9,11-DIDEOXY-11A,9A-EPOXYMETHANO-*PROSTA GLANDIN F2A

9,11-dideoxy-11α,9α-epoxymethanoprostaglandin f2α

9,11-dideoxy-11alpha,9alpha-epoxymethanoprostaglandin F2a

(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2 -oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

(5Z)-7-[(1R,4S)-6β-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]heptan-5α-yl]-5-heptenoic acid

(Z)-7-[(1R,4S)-6β-[(E,S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5α-yl]-5-heptenoic acid

11α,9α-Epoxymethanoprostaglandin H2

9,11-Methanoepoxy PGH2

9,11-Methanoxy-PGH2

9,11-Dideoxy-9α,11α-methanoepoxyprostaglandin F2α Solution

4-alpha,5-beta(z),6-alpha(1e,3s*)))-r-(1-alph

7-(6-(3-hydroxy-1-octenyl)-2-oxabicyclo(2.2.1)hept-5-yl)-5-heptenoicaci(1

9a,11a-methanoepoxy-15-hydroxyprosta-5,13-dienoicacid

U-46619

9,11-dideoxy-11A,9A-epoxymethano-*prostaglandin F

9,11-dideoxy-11alpha,9alpha-epoxymethano prostaglandin F2A S

9,11-DIDEOXY-9ALPHA, 11ALPHA-METHANOEPOXY-PROSTA-5Z,13E-DIEN-1-OIC ACID

9,11-DIDEOXY-9ALPHA, 11ALPHA-METHANOEPOXY-PROSTA-5Z,13E-DIEN-OIC ACID

9,11-DIDEOXY-9ALPHA,11ALPHA-METHANOEPOXYPROSTAGLANDIN F2ALPHA

9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA

9,11-DIDEOXY-9ALPHA,11ALPHA-METHANOEPOXY PGF2ALPHA

5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5Z)-

11-Methanoepoxy PGH2

U46619, U-46619, U 46619

U 46619,U46619

U-46619, Thromboxane A2 receptor agonist

56985-40-1

Biochemicals and Reagents

BioChemical

Prostaglandins

Lipids

Fatty Acids

Prostanoid receptor and related