ChemicalBook > CAS DataBase List > FMOC-D-2-THIENYLALANINE

FMOC-D-2-THIENYLALANINE

Product Name: FMOC-D-2-THIENYLALANINE
CAS No.: 201532-42-5
Chemical Name: FMOC-D-2-THIENYLALANINE
Synonyms: FMOC-D-THA;Fmoc-D-2-THI;FMOC-D-THI-OH;Fmoc-D-2-Thi-OH;RARECHEM BK PT 0214;FMOC-D-THIENYLALANINE;FMOC-D-2-THIENYLALANINE;FMOC-D-ALA(2-THIENYL)-OH;Fmoc-D-Thi-OH Novabiochem;FMOC-3-D-ALA(2-THIENYL)-OH
CBNumber: CB6438836
Molecular Formula: C22H19NO4S
Formula Weight: 393.46
MOL File: 201532-42-5.mol

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FMOC-D-2-THIENYLALANINE Property

Melting point:: 169 °C
Boiling point:: 623.4±55.0 °C(Predicted)
Density: 1.343±0.06 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5060 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka: 3.59±0.10(Predicted)
form: solid
color: White to off-white
InChI: InChI=1/C22H19NO4S/c24-21(25)20(12-14-6-5-11-28-14)23-22(26)27-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-11,19-20H,12-13H2,(H,23,26)(H,24,25)/t20-/s3
InChIKey: PXBMQFMUHRNKTG-XKGZFIRZNA-N
SMILES: C(C1C2=CC=CC=C2C2=CC=CC=C12)OC(=O)N[C@@H](C(=O)O)CC1SC=CC=1 |&1:18,r|
CAS DataBase Reference: 201532-42-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003855
Product name: Fmoc-<SC>D</SC>-2-thienylalanine
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 250 mg
Price: $73.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52238
Product name: Fmoc-D-Thi-OH
Purity: Novabiochem?
Packaging: 5G
Price: $691
Updated: 2025/07/31

Sigma-Aldrich

Product number: CDS003855
Product name: Fmoc-D-2-thienylalanine
Purity: AldrichCPR
Packaging: 250mg
Price: $70.9
Updated: 2024/03/01

TRC

Product number: F679623
Product name: Fmoc-D-2-thienylalanine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Chem-Impex

Product number: 02457
Product name: Fmoc-β-(2-thienyl)-D-alanine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 1G
Price: $33.6
Updated: 2021/12/16

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FMOC-D-2-THIENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

88798-28-1

82911-69-1

201532-42-5

2.3 Diethyl 2-thienylmalonate was used as the starting material, and the saponification reaction was first carried out with 2.3 equivalents of aqueous sodium hydroxide. Subsequently, L-acylase, 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and acetone were added, and the pH of the reaction system was adjusted to 8-9 with aqueous sodium carbonate.After completion of the reaction, Fmoc-Thi-OH was isolated (stored separately), and the mother liquor was frozen and stored.2.4 About 2 L of the above mother liquor was transferred to a 5 L three-necked flask, and 1 L of a mixture of hydrochloric acid and methanol mixture. The reaction mixture was heated to reflux for 60 hours. The reaction was monitored by nuclear magnetic resonance (NMR) and thin layer chromatography (TLC). When the reaction was essentially complete, the Fmoc-OSu solid was removed by filtration and the reaction process continued to be followed by TLC. After the reaction was complete, the reaction system was washed four times with 500 mL of a solvent mixture of ethyl acetate and petroleum ether. Subsequently, the reaction system was acidified with hydrochloric acid to a pH of about 1. Cooling and stirring resulted in 48 g of brown crystalline product.

References

[1] Patent: CN106565665, 2017, A. Location in patent: Paragraph 0016-0018; 0021-0023; 0026-0027; 0030-0031; 0038

FMOC-D-2-THIENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FMOC-D-2-THIENYLALANINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Fmoc-β-(2-thienyl)-D-alanine 201532-42-5
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-23

Career Henan Chemical Co

Product: FMOC-D-2-THIENYLALANINE 201532-42-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

201532-42-5, FMOC-D-2-THIENYLALANINERelated Search:

Fmoc-D-Trp(Boc)-OH FMOC-D-2-(5-BROMOTHIENYL)ALANINE FMOC-D-alanine 2-Thiophenemethylamine FMOC-D-ABU-OH 3-(2-THIENYL)PROPIONIC ACID BETA-(2-THIENYL)-DL-ALANINE 3-(2-Thienyl)-1-propanol D-2-THIENYLALANINE FMOC-L-2-THIENYLALANINE FMOC-D-3-THIENYLALANINE FMOC-L-3-THIENYLALANINE FMOC-DL-3-THIENYLALANINE 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE FMOC-3-(2-THIENYL)-DL-ALANINE FMOC-D-ALA-ALDEHYDE FMOC-D-2-THIENYLALANINE METHYL-(2-THIOPHEN-2-YL-ETHYL)-AMINE

FMOC-3-(2-THIENYL)-D-ALANINE

FMOC-D-2-THIENYLALANINE

FMOC-D-ALA(2-THIENYL)-OH

FMOC-D-THA

FMOC-D-THIENYLALANINE

FMOC-D-THI-OH

Fmoc-D-2-Thi-OH

Fmoc-D-3-(2-Thienyl)-alanine

Fmoc-D-3-(2-Thienyl)-L-alanine

(R)-N-fmoc-2-Thienylalanine(e.e.)

3-Thien-2-yl-D-alanine, N-FMOC protected

(R)-N-Fmoc-2-thienylalanine, 95%, ee:98%

(R)-N-FMOC-2-Thienylalanine, 98% ee

(αR)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-thiophenepropanoic acid

Fmoc-D-2-THI

(2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-thiophen-2-ylpropanoate

(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-2-yl)propanoic acid

(R)-N-FMOC-2-Thienylalanine,95%,98% ee

FMoc-b-(2-thienyl)-D-Ala-OH

(R)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-3-(thiophen-2-yl)propanoic acid

Fmoc-β-(2-thienyl)-D-alanine≥ 98% (HPLC)

Fmoc-D-Thi-OH Novabiochem

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-(2-THIENYL)-D-ALANINE

N-(9-FLUORENYLMETHOXYCARBONYL)-2-THIENYL-D-ALANINE

N-ALPHA-FMOC-BETA-THIENYL-D-ALANINE

RARECHEM BK PT 0214

(R)-N-FMOC-2-THIENYLALANINE

FMOC-3-D-ALA(2-THIENYL)-OH

FMOC-BETA-(2-THIENYL)-D-ALANINE

FMOC-BETA-(2-THIENYL)-D-ALA-OH

FMOC-D-THI-OH (FMOC-D-3-(2-THIENYL)-ALANINE)

(9H-Fluoren-9-yl)MethOxy]Carbonyl β-(2-thienyl)-D-Alanine

N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-3-(thien-2-yl)-D-alanine, (2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(thien-2-yl)propanoic acid

FMoc-β-(2-thienyl)-D-alanine, ee: 98%

Fmoc-β-(2-thienyl)-D-alanine

2-Thiophenepropanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αR)-

FMOC-D-2-THIENYLALANINE USP/EP/BP

(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-thiophen-2-ylpropanoate

Fmoc-3-(2-thienyl)-D-Ala-OH

N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(thiophen-2-yl)-D-alanine

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid - [F90760]

201532-42-5

C22HNO4S

C22H18NO4S

Phenylalanine analogs and other aromatic alpha amino acids

Amino Acid Derivatives

a-amino

Amino Acids