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FMOC-D-2-THIENYLALANINE

Product Name
FMOC-D-2-THIENYLALANINE
CAS No.
201532-42-5
Chemical Name
FMOC-D-2-THIENYLALANINE
Synonyms
FMOC-D-THA;Fmoc-D-2-THI;FMOC-D-THI-OH;Fmoc-D-2-Thi-OH;RARECHEM BK PT 0214;FMOC-D-THIENYLALANINE;FMOC-D-2-THIENYLALANINE;FMOC-D-ALA(2-THIENYL)-OH;Fmoc-D-Thi-OH Novabiochem;FMOC-3-D-ALA(2-THIENYL)-OH
CBNumber
CB6438836
Molecular Formula
C22H19NO4S
Formula Weight
393.46
MOL File
201532-42-5.mol
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FMOC-D-2-THIENYLALANINE Property

Melting point:
169 °C
Boiling point:
623.4±55.0 °C(Predicted)
Density 
1.343±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5060 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka
3.59±0.10(Predicted)
form 
solid
color 
White to off-white
InChI
InChI=1/C22H19NO4S/c24-21(25)20(12-14-6-5-11-28-14)23-22(26)27-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-11,19-20H,12-13H2,(H,23,26)(H,24,25)/t20-/s3
InChIKey
PXBMQFMUHRNKTG-XKGZFIRZNA-N
SMILES
C(C1C2=CC=CC=C2C2=CC=CC=C12)OC(=O)N[C@@H](C(=O)O)CC1SC=CC=1 |&1:18,r|
CAS DataBase Reference
201532-42-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS003855
Product name
Fmoc-<SC>D</SC>-2-thienylalanine
Purity
Aldrich<SUP>CPR</SUP>
Packaging
250 mg
Price
$73.1
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52238
Product name
Fmoc-D-Thi-OH
Purity
Novabiochem?
Packaging
5G
Price
$691
Updated
2025/07/31
Sigma-Aldrich
Product number
CDS003855
Product name
Fmoc-D-2-thienylalanine
Purity
AldrichCPR
Packaging
250mg
Price
$70.9
Updated
2024/03/01
TRC
Product number
F679623
Product name
Fmoc-D-2-thienylalanine
Packaging
250mg
Price
$70
Updated
2021/12/16
Chem-Impex
Product number
02457
Product name
Fmoc-&beta;-(2-thienyl)-D-alanine,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$33.6
Updated
2021/12/16
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FMOC-D-2-THIENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

88798-28-1

82911-69-1

201532-42-5

2.3 Diethyl 2-thienylmalonate was used as the starting material, and the saponification reaction was first carried out with 2.3 equivalents of aqueous sodium hydroxide. Subsequently, L-acylase, 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and acetone were added, and the pH of the reaction system was adjusted to 8-9 with aqueous sodium carbonate.After completion of the reaction, Fmoc-Thi-OH was isolated (stored separately), and the mother liquor was frozen and stored.2.4 About 2 L of the above mother liquor was transferred to a 5 L three-necked flask, and 1 L of a mixture of hydrochloric acid and methanol mixture. The reaction mixture was heated to reflux for 60 hours. The reaction was monitored by nuclear magnetic resonance (NMR) and thin layer chromatography (TLC). When the reaction was essentially complete, the Fmoc-OSu solid was removed by filtration and the reaction process continued to be followed by TLC. After the reaction was complete, the reaction system was washed four times with 500 mL of a solvent mixture of ethyl acetate and petroleum ether. Subsequently, the reaction system was acidified with hydrochloric acid to a pH of about 1. Cooling and stirring resulted in 48 g of brown crystalline product.

References

[1] Patent: CN106565665, 2017, A. Location in patent: Paragraph 0016-0018; 0021-0023; 0026-0027; 0030-0031; 0038

FMOC-D-2-THIENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-D-2-THIENYLALANINE Suppliers

Belgium 1 China 92 Europe 1 France 2 Germany 4 India 3 Japan 1 Switzerland 1 United Kingdom 7 United States 21 Global 133
Senn Chemicals AG
Tel
--
Fax
--
Email
swiss@sennchem.com
Country
Switzerland
ProdList
3143
Advantage
71
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View Lastest Price from FMOC-D-2-THIENYLALANINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Fmoc-β-(2-thienyl)-D-alanine 201532-42-5
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-23
Career Henan Chemical Co
Product
FMOC-D-2-THIENYLALANINE 201532-42-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

201532-42-5, FMOC-D-2-THIENYLALANINERelated Search:

Fmoc-D-Trp(Boc)-OH FMOC-D-2-(5-BROMOTHIENYL)ALANINE FMOC-D-alanine 2-Thiophenemethylamine FMOC-D-ABU-OH 3-(2-THIENYL)PROPIONIC ACID BETA-(2-THIENYL)-DL-ALANINE 3-(2-Thienyl)-1-propanol D-2-THIENYLALANINE FMOC-L-2-THIENYLALANINE FMOC-D-3-THIENYLALANINE FMOC-L-3-THIENYLALANINE FMOC-DL-3-THIENYLALANINE 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE FMOC-3-(2-THIENYL)-DL-ALANINE FMOC-D-ALA-ALDEHYDE FMOC-D-2-THIENYLALANINE METHYL-(2-THIOPHEN-2-YL-ETHYL)-AMINE

  • FMOC-3-(2-THIENYL)-D-ALANINE
  • FMOC-D-2-THIENYLALANINE
  • FMOC-D-ALA(2-THIENYL)-OH
  • FMOC-D-THA
  • FMOC-D-THIENYLALANINE
  • FMOC-D-THI-OH
  • Fmoc-D-2-Thi-OH
  • Fmoc-D-3-(2-Thienyl)-alanine
  • Fmoc-D-3-(2-Thienyl)-L-alanine
  • (R)-N-fmoc-2-Thienylalanine(e.e.)
  • 3-Thien-2-yl-D-alanine, N-FMOC protected
  • (R)-N-Fmoc-2-thienylalanine, 95%, ee:98%
  • (R)-N-FMOC-2-Thienylalanine, 98% ee
  • (αR)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-thiophenepropanoic acid
  • Fmoc-D-2-THI
  • (2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-thiophen-2-ylpropanoate
  • (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-2-yl)propanoic acid
  • (R)-N-FMOC-2-Thienylalanine,95%,98% ee
  • FMoc-b-(2-thienyl)-D-Ala-OH
  • (R)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-3-(thiophen-2-yl)propanoic acid
  • Fmoc-β-(2-thienyl)-D-alanine≥ 98% (HPLC)
  • Fmoc-D-Thi-OH Novabiochem
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-(2-THIENYL)-D-ALANINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-2-THIENYL-D-ALANINE
  • N-ALPHA-FMOC-BETA-THIENYL-D-ALANINE
  • RARECHEM BK PT 0214
  • (R)-N-FMOC-2-THIENYLALANINE
  • FMOC-3-D-ALA(2-THIENYL)-OH
  • FMOC-BETA-(2-THIENYL)-D-ALANINE
  • FMOC-BETA-(2-THIENYL)-D-ALA-OH
  • FMOC-D-THI-OH (FMOC-D-3-(2-THIENYL)-ALANINE)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl β-(2-thienyl)-D-Alanine
  • N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-3-(thien-2-yl)-D-alanine, (2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(thien-2-yl)propanoic acid
  • FMoc-β-(2-thienyl)-D-alanine, ee: 98%
  • Fmoc-β-(2-thienyl)-D-alanine
  • 2-Thiophenepropanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αR)-
  • FMOC-D-2-THIENYLALANINE USP/EP/BP
  • (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-thiophen-2-ylpropanoate
  • Fmoc-3-(2-thienyl)-D-Ala-OH
  • N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(thiophen-2-yl)-D-alanine
  • (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid - [F90760]
  • 201532-42-5
  • C22HNO4S
  • C22H18NO4S
  • Phenylalanine analogs and other aromatic alpha amino acids
  • Amino Acid Derivatives
  • a-amino
  • Amino Acids