ChemicalBook > CAS DataBase List > HECOGENIN ACETATE

HECOGENIN ACETATE

Product Name
HECOGENIN ACETATE
CAS No.
915-35-5
Chemical Name
HECOGENIN ACETATE
Synonyms
HECOGENIN ACETATE;HECOGENIN ALCOHOL;HecogeninAcetate>(-)-HECOGENIN ACETATE, TECH., 90%;(25R)-3β-Acetoxy-5α-spirostane-12-one;Hecogenin acetate,()-Hecogenin acetate;(25R)-3β-Acetyloxy-5α-spirostan-12-one;(22R,25R)-3β-Acetoxy-5α-spirostane-12-one;12-oxo-5-alpha-spirostan-3-beta-yl acetate;(25R)-3β-Hydroxy-5α-spirostane-12-one=acetate
CBNumber
CB6442059
Molecular Formula
C29H44O5
Formula Weight
472.66
MOL File
915-35-5.mol
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HECOGENIN ACETATE Property

Melting point:
246-248 °C (dec.)(lit.)
Boiling point:
95-140 °C
Density 
1.15±0.1 g/cm3(Predicted)
refractive index 
-4 ° (C=1, Dioxane)
storage temp. 
Refrigerator
solubility 
Chloroform (Sparingly), Dioxane (Sparingly, Heated), Ethyl Acetate (Slightly, Heated)
form 
Solid
color 
White
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2937.29.9095
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H4274
Product name
Hecogenin acetate
Purity
≥90%
Packaging
25g
Price
$664
Updated
2023/01/07
TCI Chemical
Product number
H0537
Product name
Hecogenin Acetate
Purity
>90.0%(GC)
Packaging
1g
Price
$62
Updated
2025/07/31
TCI Chemical
Product number
H0537
Product name
Hecogenin Acetate
Purity
>90.0%(GC)
Packaging
5g
Price
$160
Updated
2025/07/31
Cayman Chemical
Product number
25977
Product name
Hecogenin Acetate
Purity
≥98%
Packaging
1g
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
25977
Product name
Hecogenin Acetate
Purity
≥98%
Packaging
5g
Price
$166
Updated
2024/03/01
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HECOGENIN ACETATE Chemical Properties,Usage,Production

Description

Hecogenin acetate is a steroid sapogenin and an acetylated form of hecogenin that has anthelmintic and antinociceptive properties. It reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus, Oesophagostomum, and Trichostrongylus nematodes (EC50 = 0.49 mg/ml). Hecogenin acetate (5, 10, or 20 mg/kg, i.p.) inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine , and prostaglandin E2 (PGE2; ) in mice. It also increases latency to tail withdrawal in the tail flick test and has no effect on motor performance in the rotarod test in mice when administered at a dose of 40 mg/kg.

Uses

Hecogenin Acetate, is a derivative of Hecogenin (H129945), which is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.

Definition

ChEBI: HECOGENIN ACETATE is a triterpenoid.

Purification Methods

Crystallise the acetate from MeOH. [Beilstein 19 IV 2583.]

References

[1] ACIDáLIA CARINE VIEIRA SANTOS. In vitro ovicidal and larvicidal activities of some saponins and flavonoids against parasitic nematodes of goats.[J]. Parasitology, 2018, 145 14: 1884-1889. DOI: 10.1017/s0031182018000689
[2] JULLYANA S S QUINTANS. Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.[J]. Molecules, 2014, 19 6: 8303-8316. DOI: 10.3390/molecules19068303
[3] KELLY BARBOSA GAMA. Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate[J]. Journal of Natural Products , 2013, 76 4: 559-563. DOI: 10.1021/np3007342

HECOGENIN ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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HECOGENIN ACETATE Suppliers

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View Lastest Price from HECOGENIN ACETATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
HECOGENIN ACETATE 915-35-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000KG
Release date
2024-08-25

915-35-5, HECOGENIN ACETATERelated Search:

2,2-DIMETHYL-3-HEXANONE HEPTANAL DIMETHYL ACETAL LAURYL ALDEHYDE DIMETHYL ACETAL HECOGENIN ACETATE 3-METHYLCYCLOHEXANONE 8-PENTADECANONE ISOVERTAL 411 L 7-HEXADECANONE 2-methoxytetrahydrofuran 2-ETHOXYTETRAHYDROFURAN PROPIONALDEHYDE DIETHYL ACETAL 2-METHYL-3-NONANONE N-HEPTADECYLCYCLOHEXANE 7-PENTADECANONE 1,1-Dimethoxyoctane Saponin Hecogenin ACETIC ACID 2-NONYL ESTER

  • 25R,5ALPHA-SPIROSTAN-3BETA-OL-12-ONE 3-ACETATE
  • 5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL-12-ONE ACETATE
  • HECOGENIN ACETATE
  • 12-oxo-5-alpha-spirostan-3-beta-yl acetate
  • (-)-HECOGENIN ACETATE, TECH., 90%
  • HECOGENIN ALCOHOL
  • (22R,25R)-3β-Acetoxy-5α-spirostane-12-one
  • (25R)-3β-Acetoxy-5α-spirostane-12-one
  • (25R)-3β-Acetyloxy-5α-spirostan-12-one
  • (25R)-3β-Hydroxy-5α-spirostane-12-one=acetate
  • Hecogenin acetate,()-Hecogenin acetate
  • HecogeninAcetate&gt
  • Spirostan-12-one, 3-(acetyloxy)-, (3β,5α,25R)-
  • 5α, 20α, 22α, 25D-SPIROSTAN-3β-OL-12-ONE ACETATE
  • 915-35-5
  • C29H44O5
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