DISUCCINIMIDYL SUCCINATE

Product Name: DISUCCINIMIDYL SUCCINATE
CAS No.: 30364-60-4
Chemical Name: DISUCCINIMIDYL SUCCINATE
Synonyms: DISUCCINIMIDYL SUCCINATE;Bis(2,5-dioxopyrrolidin-1-yl);N,N'-(Succinyldioxy)disuccinimide;Succinic Acid Disuccinimidyl Ester;Bis(2,5-dioxopyrrolidin-1-yl) succinate;Bis(2,5-dioxo-1-pyrrolidinyl) Succinate;bis(2,5-dioxopyrrolidin-1-yl) butanedioate;SUCCINIC ACID-BIS-N-HYDROXYSUCCINIMIDE ESTER;SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER;Butanedioic acid,1,4-bis(2,5-dioxo-1-pyrrolidinyl) ester
CBNumber: CB6448859
Molecular Formula: C12H12N2O8
Formula Weight: 312.23
MOL File: 30364-60-4.mol

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DISUCCINIMIDYL SUCCINATE Property

Melting point:: 305-306℃
Boiling point:: 471.6±55.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Safety

HS Code: 2928.00.5000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S283339
Product name: SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER
Purity: AldrichCPR
Packaging: 25MG
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: D5622
Product name: Disuccinimidyl Succinate
Packaging: 250MG
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: D5622
Product name: Disuccinimidyl Succinate
Packaging: 1G
Price: $84
Updated: 2025/07/31

Chem-Impex

Product number: 39691
Product name: Disuccinimidylsuccinate,≥98%(NMR)
Purity: ≥98%(NMR)
Packaging: 100MG
Price: $52
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142264
Product name: Bis(2,5-dioxopyrrolidin-1-yl) succinate
Packaging: 100mg
Price: $58
Updated: 2021/12/16

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DISUCCINIMIDYL SUCCINATE Chemical Properties,Usage,Production

Synthesis

6066-82-6

110-15-6

30364-60-4

General procedure for the synthesis of bis(2,5-dioxopyrrolidin-1-yl) succinic acid esters from N-hydroxybutanediimide and butanedioic acid: to a solution of THF (50 mL) of butanedioic acid (30 g, 254 mmol, 1.0 eq.) was added a solution of THF (50 mL) of N-hydroxybutanediimide (64 g, 556 mmol, 2.2 eq.). A THF (50 mL) solution of N,N'-dicyclohexylcarbodiimide (DCC, 11.5 g, 55.8 mmol, 0.22 eq.) was slowly added dropwise with stirring at 0 °C. After dropwise addition, the reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS). After completion of the reaction, the solid was collected by filtration and the filtrate was concentrated to obtain the crude product. The resulting solid was washed sequentially with THF and ethanol to give the final bis(2,5-dioxopyrrolidin-1-yl) succinate (24 g, 27% yield) as a white solid.

References

[1] Patent: WO2010/78449, 2010, A2. Location in patent: Page/Page column 291
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980, vol. 29, # 5, p. 785 - 789
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980, # 5, p. 1078 - 1081
[4] Chemical Papers, 2016, vol. 70, # 4, p. 505 - 514
[5] Patent: WO2016/205488, 2016, A1. Location in patent: Paragraph 0264

DISUCCINIMIDYL SUCCINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DISUCCINIMIDYL SUCCINATE Suppliers

Americas 1 China 79 Europe 1 France 1 Germany 1 India 2 Japan 1 South Korea 1 Sweden 1 United Kingdom 3 United States 5 Global 96

Meryer (Shanghai) Chemical Technology Co., Ltd.

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Shanghai CanSpecsci Instrument Co., Ltd.

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Shanghai Xingui Biotechnology Co., Ltd.

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View Lastest Price from DISUCCINIMIDYL SUCCINATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DISUCCINIMIDYL SUCCINATE 30364-60-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-25

Career Henan Chemical Co

Product: DISUCCINIMIDYL SUCCINATE 30364-60-4
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

30364-60-4, DISUCCINIMIDYL SUCCINATERelated Search:

Heptanedioic acid 1,7-bis(2,5-dioxo-1-pyrrolidinyl) ester DISUCCINIMIDYL SEBACATE Di(N-succinimidyl) adipate N-Boc-N,N-bis(2-bromoethyl)amine Succinic acid POLY(ETHYLENE GLYCOL) DISUCCINIMIDYL SUCCINATE BIS(SULFOSUCCINIMIDYL)SUCCINATE SODIUM SALT DISUCCINIMIDYL SUCCINATE DISULFOSUCCINIMIDYL TARTRATE DISULPHOSUCCINIMIDYL TARTARATE IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER DISULFOSUCCINIMIDYL-L-TARTRATE

DISUCCINIMIDYL SUCCINATE

SUCCINIC ACID-BIS-N-HYDROXYSUCCINIMIDE ESTER

2,5-Pyrrolidinedione, 1,1'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis-

N,N'-(Succinyldioxy)disuccinimide

Bis(2,5-dioxopyrrolidin-1-yl) succinate

Butanedioic acid,1,4-bis(2,5-dioxo-1-pyrrolidinyl) ester

Bis(2,5-dioxopyrrolidin-1-yl)

Succinic Acid Disuccinimidyl Ester

bis(2,5-dioxopyrrolidin-1-yl) butanedioate

Bis(2,5-dioxo-1-pyrrolidinyl) Succinate

SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER

SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER

30364-60-4

C12H12N2O8

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