ChemicalBook > CAS DataBase List > DISUCCINIMIDYL SUCCINATE
DISUCCINIMIDYL SUCCINATE
- Product Name
- DISUCCINIMIDYL SUCCINATE
- CAS No.
- 30364-60-4
- Chemical Name
- DISUCCINIMIDYL SUCCINATE
- Synonyms
- DISUCCINIMIDYL SUCCINATE;Bis(2,5-dioxopyrrolidin-1-yl);N,N'-(Succinyldioxy)disuccinimide;Succinic Acid Disuccinimidyl Ester;Bis(2,5-dioxopyrrolidin-1-yl) succinate;Bis(2,5-dioxo-1-pyrrolidinyl) Succinate;bis(2,5-dioxopyrrolidin-1-yl) butanedioate;SUCCINIC ACID-BIS-N-HYDROXYSUCCINIMIDE ESTER;SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER;Butanedioic acid,1,4-bis(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber
- CB6448859
- Molecular Formula
- C12H12N2O8
- Formula Weight
- 312.23
- MOL File
- 30364-60-4.mol
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DISUCCINIMIDYL SUCCINATE Property
- Melting point:
- 305-306℃
- Boiling point:
- 471.6±55.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
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Safety
- HS Code
- 2928.00.5000
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S283339
- Product name
- SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $179
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D5622
- Product name
- Disuccinimidyl Succinate
- Packaging
- 250MG
- Price
- $31
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D5622
- Product name
- Disuccinimidyl Succinate
- Packaging
- 1G
- Price
- $84
- Updated
- 2025/07/31
Chem-Impex
- Product number
- 39691
- Product name
- Disuccinimidylsuccinate,≥98%(NMR)
- Purity
- ≥98%(NMR)
- Packaging
- 100MG
- Price
- $52
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB142264
- Product name
- Bis(2,5-dioxopyrrolidin-1-yl) succinate
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
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DISUCCINIMIDYL SUCCINATE Chemical Properties,Usage,Production
Synthesis
6066-82-6
110-15-6
30364-60-4
General procedure for the synthesis of bis(2,5-dioxopyrrolidin-1-yl) succinic acid esters from N-hydroxybutanediimide and butanedioic acid: to a solution of THF (50 mL) of butanedioic acid (30 g, 254 mmol, 1.0 eq.) was added a solution of THF (50 mL) of N-hydroxybutanediimide (64 g, 556 mmol, 2.2 eq.). A THF (50 mL) solution of N,N'-dicyclohexylcarbodiimide (DCC, 11.5 g, 55.8 mmol, 0.22 eq.) was slowly added dropwise with stirring at 0 °C. After dropwise addition, the reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS). After completion of the reaction, the solid was collected by filtration and the filtrate was concentrated to obtain the crude product. The resulting solid was washed sequentially with THF and ethanol to give the final bis(2,5-dioxopyrrolidin-1-yl) succinate (24 g, 27% yield) as a white solid.
References
[1] Patent: WO2010/78449, 2010, A2. Location in patent: Page/Page column 291
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980, vol. 29, # 5, p. 785 - 789
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980, # 5, p. 1078 - 1081
[4] Chemical Papers, 2016, vol. 70, # 4, p. 505 - 514
[5] Patent: WO2016/205488, 2016, A1. Location in patent: Paragraph 0264
DISUCCINIMIDYL SUCCINATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DISUCCINIMIDYL SUCCINATE manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- DISUCCINIMIDYL SUCCINATE 30364-60-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-25
Career Henan Chemical Co
- Product
- DISUCCINIMIDYL SUCCINATE 30364-60-4
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09
30364-60-4, DISUCCINIMIDYL SUCCINATERelated Search:
Heptanedioic acid 1,7-bis(2,5-dioxo-1-pyrrolidinyl) ester
DISUCCINIMIDYL SEBACATE
Di(N-succinimidyl) adipate
N-Boc-N,N-bis(2-bromoethyl)amine
Succinic acid
POLY(ETHYLENE GLYCOL) DISUCCINIMIDYL SUCCINATE
BIS(SULFOSUCCINIMIDYL)SUCCINATE SODIUM SALT
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DISULFOSUCCINIMIDYL TARTRATE
DISULPHOSUCCINIMIDYL TARTARATE
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
DISULFOSUCCINIMIDYL-L-TARTRATE