2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
- Product Name
- 2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
- CAS No.
- 104253-44-3
- Chemical Name
- 2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
- Synonyms
- RARECHEM AL BF 0717;METHYL 2-CHLORO-4-HYDROXYBENZOATE;2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 2-chloro-4-hydroxy-, methyl ester;2-Chloro-4-hydroxy-benzoic acid methyl ester≥ 99% (GC)
- CBNumber
- CB6452966
- Molecular Formula
- C8H7ClO3
- Formula Weight
- 186.59
- MOL File
- 104253-44-3.mol
2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Property
- Boiling point:
- 298.3±20.0 °C(Predicted)
- Density
- 1.354±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.39±0.18(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M340458
- Product name
- Methyl2-Chloro-4-hydroxybenzoate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FC70262
- Product name
- 2-Chloro-4-hydroxybenzoic acid methyl ester
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- OR913032
- Product name
- 2-Chloro-4-hydroxy-benzoic acid methyl ester
- Purity
- 98%
- Packaging
- 1g
- Price
- $94
- Updated
- 2021/12/16
- Product number
- FC70262
- Product name
- 2-Chloro-4-hydroxybenzoic acid methyl ester
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Z3835
- Product name
- Methyl2-chloro-4-hydroxybenzoate
- Packaging
- 2g
- Price
- $117
- Updated
- 2021/12/16
2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Tan crystalline powder
Synthesis
67-56-1
56363-84-9
104253-44-3
General procedure for the synthesis of methyl 2-chloro-4-hydroxybenzoate from methanol and 2-chloro-4-hydroxybenzoic acid: sulfoxide chloride (SOCl2, 1.5 mL) was slowly added to a solution of methanol (10 mL) containing 2-chloro-4-hydroxybenzoic acid (5 g, 0.03 mol). The reaction mixture was gradually heated from room temperature to reflux temperature and reacted under reflux conditions for 12 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford the target product methyl 2-chloro-4-hydroxybenzoate (Compound 132A, red solid, 5.4 g, 100% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 10.71 (s, 1H), 7.84-7.71 (m, 1H), 6.91 (d, J = 2.4 Hz, 1H), 6.82 (dd, J = 2.4, 8.7 Hz, 1H), 3.79 (s, 3H).
References
[1] Patent: EP3293177, 2018, A1. Location in patent: Paragraph 0332; 0333
[2] Patent: EP1764360, 2007, A1. Location in patent: Page/Page column 176-177
[3] Patent: WO2017/84629, 2017, A1. Location in patent: Paragraph 00316
[4] Patent: WO2017/84630, 2017, A1. Location in patent: Paragraph 00648
[5] Patent: WO2008/157330, 2008, A1. Location in patent: Page/Page column 87
2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER manufacturers
- Product
- 2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 104253-44-3
- Price
- US $9.20/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2020-10-27