Ritanserin
- Product Name
- Ritanserin
- CAS No.
- 87051-43-2
- Chemical Name
- Ritanserin
- Synonyms
- R 55667;Tiserton;RITANSERIN;RITANSERIN SEROTONIN ANTAGONIST;6-[2-[4-[Bis(4-fluorophenyl)Methylidene]piperidin-1-yl]ethyl]-7-Methyl-[1,3]thia;6-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimi;6-[2-[4-[BIS(4-FLUOROPHENYL)-METHYLENE]-1-PIPERIDINYL]-ETHYL]-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE;6-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin;6-[2-[4-[Bis(4-fluorophenyl)methylene]-piperidino]ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidin-5-one;6-[2-[4-[Bis(4-fluorophenyl)methylene]piperidin-1-yl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
- CBNumber
- CB6458180
- Molecular Formula
- C27H25F2N3OS
- Formula Weight
- 477.57
- MOL File
- 87051-43-2.mol
Ritanserin Property
- Melting point:
- 145.5°
- Boiling point:
- 618.7±65.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- methanol: >10 mg/mL
- form
- solid
- pka
- 7.74±0.20(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- R103
- Product name
- Ritanserin
- Purity
- powder
- Packaging
- 25mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- R103
- Product name
- Ritanserin
- Purity
- powder
- Packaging
- 100mg
- Price
- $240
- Updated
- 2024/03/01
- Product number
- 21374
- Product name
- Ritanserin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 21374
- Product name
- Ritanserin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- R103
- Product name
- Ritanserin
- Purity
- powder
- Packaging
- 250mg
- Price
- $837
- Updated
- 2024/03/01
Ritanserin Chemical Properties,Usage,Production
Description
Ritanserin, also known by its developmental code name R-55667, is a serotonin antagonist medication described as an anxiolytic, antidepressant, antiparkinsonian agent, and antihypertensive agent. It was never marketed for medical use due to safety problems but has been used in scientific research to study the serotonin system.
Uses
Ritanserin and other 5HT2A/2C receptor antagonists have shown in clinical trial to promote slow-wave sleep in chronic primary insomnia or generalized anxiety disorder (Mayer, 2003).
Uses
Ritanserin has been used in behavioral testing and as a serotonin 2A receptor (5-HT2A)-receptor antagonist.
Definition
ChEBI: Ritanserin is a thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action. It has a role as a dopaminergic antagonist, a serotonergic antagonist, an antipsychotic agent, an anxiolytic drug, an antidepressant and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is an organofluorine compound, a member of piperidines and a thiazolopyrimidine.
brand name
Tiserton (Janssen).
Hazard
A poison.
Biological Activity
Ritanserin acts as a potent and long-acting 5-HT 2 receptor; antagonist (Ki = 0.39nM).Anxiolytic in vivo .It has relatively low affinity for the H1, D2, α1-adrenergic, and α2-adrenergic receptors (39-, 77-, 107-, and 166-fold lower relative to 5-HT2A, respectively).
Biochem/physiol Actions
Potent 5-HT2A serotonin receptor antagonist/inverse agonist that crosses the blood-brain barrier.
storage
Store at +4°C
Ritanserin Preparation Products And Raw materials
Raw materials
Preparation Products
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