ChemicalBook > CAS DataBase List > 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID

6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID

Product Name
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
CAS No.
153559-76-3
Chemical Name
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
Synonyms
LG 268;CD 3127;lg100268;ALRT 268;LGD 1268;AGN 192620;LGD 100268;hthalenyl)cyclopropyl)-;3-pyridinecarboxylicacid,6-(1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-nap;6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]nicotinic Acid
CBNumber
CB6458625
Molecular Formula
C24H29NO2
Formula Weight
363.49
MOL File
153559-76-3.mol
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6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Property

Melting point:
275-277°C
Boiling point:
487.0±33.0 °C(Predicted)
Density 
1.115±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: ≥5mg/mL (warmed)
pka
2.35±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0279
Product name
LG100268
Purity
≥98% (HPLC)
Packaging
5mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0279
Product name
LG100268
Purity
≥98% (HPLC)
Packaging
25mg
Price
$568
Updated
2024/03/01
Cayman Chemical
Product number
21606
Product name
LG 100268
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21606
Product name
LG 100268
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
21606
Product name
LG 100268
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
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6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).

Biochem/physiol Actions

LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.

storage

Store at -20°C

6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Suppliers

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153559-76-3, 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACIDRelated Search:

6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID 6-TERT-BUTYL-3-FORMYLPYRIDINE 1,4,6,7-TETRAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE 1,2,4-TRI-ISO-PROPYLBENZENE METHYL 6-(1-(1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTHALEN-7-YL)CYCLOPROPYL)PYRIDINE-3-CARBOXYLATE

  • 2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid
  • 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
  • 6-[1-(3,5,5,8,8-PentaMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid
  • 3-Pyridinecarboxylicacid,6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)cyclopropyl]-
  • 3-pyridinecarboxylicacid,6-(1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-nap
  • hthalenyl)cyclopropyl)-
  • lg100268
  • 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID (FOR R&D ONLY)
  • 6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]- 3-Pyridinecarboxylic Acid
  • AGN 192620
  • ALRT 268
  • CD 3127
  • LG 268
  • LGD 100268
  • LGD 1268
  • 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]nicotinic Acid
  • 153559-76-3
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Retinoids