ChemicalBook > CAS DataBase List > PSI-7977-13C-d3

PSI-7977-13C-d3

Product Name
PSI-7977-13C-d3
CAS No.
2070009-25-3
Chemical Name
PSI-7977-13C-d3
Synonyms
PSI-7977-13C-d3;13C,D3-Sofosbuvir;[13C,2H3]-Sofosbuvir;L-Alanine, N-[[P(S),2′R]-2′-deoxy-2′-fluoro-2′-(methyl-13C-d3)-P-phenyl-5′-uridylyl]-, 1-methylethyl ester;isopropyl((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-(methyl-13C-d3)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate;Sofosbuvir 13CD3Q: What is Sofosbuvir 13CD3 Q: What is the CAS Number of Sofosbuvir 13CD3 Q: What is the storage condition of Sofosbuvir 13CD3 Q: What are the applications of Sofosbuvir 13CD3
CBNumber
CB64666758
Molecular Formula
C22H26D3FN3O9P
Formula Weight
533.46
MOL File
2070009-25-3.mol
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PSI-7977-13C-d3 Property

Density 
1.413±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.2 mg/ml
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25045
Product name
PSI-7977-13C-d3
Purity
≥99% deuterated forms (d1-d3)
Packaging
1mg
Price
$456
Updated
2024/03/01
TRC
Product number
P839642
Product name
PSI-7977-13CD3
Packaging
1mg
Price
$220
Updated
2021/12/16
Usbiological
Product number
463192
Product name
PSI-7977-13CD3
Packaging
1mg
Price
$531
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
52859
Product name
PSI-7977-13CD3
Packaging
1mg
Price
$700
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
52859
Product name
PSI-7977-13CD3
Packaging
10mg
Price
$2600
Updated
2021/12/16
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PSI-7977-13C-d3 Chemical Properties,Usage,Production

Description

PSI-7977-13C-d3 is intended for use as an internal standard for the quantification of PSI-7977 by GC- or LC-MS. PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.

Uses

PSI-7977-13CD3 is the isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

References

[1] EISUKE MURAKAMI. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.[J]. The Journal of Biological Chemistry, 2010, 285 45: 34337-34347. DOI: 10.1074/jbc.m110.161802
[2] MICHAEL J. SOFIA*. Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus[J]. Journal of Medicinal Chemistry, 2010, 53 19: 7202-7218. DOI: 10.1021/jm100863x
[3] ANGELA M LAM. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.[J]. Antimicrobial Agents and Chemotherapy, 2012, 56 6: 3359-3368. DOI: 10.1128/aac.00054-12
[4] EDWARD J GANE. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.[J]. The New England Journal of Medicine, 2013: 34-44. DOI: 10.1056/nejmoa1208953
[5] ERIC LAWITZ. Sofosbuvir for previously untreated chronic hepatitis C infection.[J]. New England Journal of Medicine, 2013, 368 20: 1878-1887. DOI: 10.1056/nejmoa1214853

PSI-7977-13C-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

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PSI-7977-13C-d3 Suppliers

China 14 India 1 United States 5 Global 20
United States Biological
Tel
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Fax
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Email
sales@advtechind.com
Country
United States
ProdList
6075
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58
Cayman Chemical Company
Tel
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
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Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80
MedChemExpress
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Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Medical Isotopes, Inc
Tel
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Fax
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Email
info@medicalisotopes.com
Country
United States
ProdList
3180
Advantage
58

2070009-25-3, PSI-7977-13C-d3Related Search:

Sofosbuvir IMpurity ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate Sofosbuvir Impurity 8 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Cytidine,N-benzoyl-2^-C-Methyl-,3^,5^-dibenzoate(9CI) Sofosbuvir alpha-D-erythro-Pentofuranous-2-ulose 1,3,5-tribenzoate Sofosbuvir Impurity 19 PSI 352707-13C,D3 PSI-7976 Sofosbuvir D6 Sofosbuvir Impurity Sofosbuvir metabolites GS566500 Sofosbuvir metabolites PSI 7411 Sofosbuvir Impurity 32 PSI-6206 13CD3 (2R,3R,4R,5S)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-fluoro-4-Methyltetrahydrofuran-3-yl benzoate

  • [13C,2H3]-Sofosbuvir
  • isopropyl((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-(methyl-13C-d3)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
  • Sofosbuvir 13CD3Q: What is Sofosbuvir 13CD3 Q: What is the CAS Number of Sofosbuvir 13CD3 Q: What is the storage condition of Sofosbuvir 13CD3 Q: What are the applications of Sofosbuvir 13CD3
  • PSI-7977-13C-d3
  • L-Alanine, N-[[P(S),2′R]-2′-deoxy-2′-fluoro-2′-(methyl-13C-d3)-P-phenyl-5′-uridylyl]-, 1-methylethyl ester
  • 13C,D3-Sofosbuvir
  • 2070009-25-3
  • C2113CH26D3FN3O9P