Glumetinib

ChemicalBook > CAS DataBase List > Glumetinib

Product Name: Glumetinib
CAS No.: 1642581-63-2
Chemical Name: Glumetinib
Synonyms: SCC244;Glumetinib;Gumarontinib;GLUMETINIB (SCC244);Fenbuconazole Impurity 1;6-(1-Methyl-1H-pyrazol-4-yl)-1-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)sulfonyl)-1H-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-;SCC 244,proliferation,tumor,cancer,Glumetinib,bioavailable,oral,HCC,SCC-244,inhibit,c-Met/HGFR,ATP-competitive,cell,NSCLC,Inhibitor
CBNumber: CB64667942
Molecular Formula: C21H17N9O2S
Formula Weight: 459.48
MOL File: 1642581-63-2.mol

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Glumetinib Property

Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 0.09±0.10(Predicted)
color: Beige
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28952
Product name: Glumetinib
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 28952
Product name: Glumetinib
Packaging: 25mg
Price: $638
Updated: 2024/03/01

Cayman Chemical

Product number: 28952
Product name: Glumetinib
Packaging: 5mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 28952
Product name: Glumetinib
Packaging: 10mg
Price: $290
Updated: 2024/03/01

AK Scientific

Product number: 1891EF
Product name: Glumetinib
Packaging: 10mg
Price: $421
Updated: 2021/12/16

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Glumetinib Chemical Properties,Usage,Production

Description

Glumetinib (1642581-63-2) is a highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-Met kinase.? It induced tumor regression in MET-driven CDX (MKN-45, SNU-5, EBC-1) and PDX (4 NSCLC, 5 HCC) tumor models.

References

Ai et al. (2018), Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models; Cancer Res., 17 751

Glumetinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Glumetinib Suppliers

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1642581-63-2, GlumetinibRelated Search:

NOTUMib-1 BI 2536 Imiquimod NORFLUOXETINE HYDROCHLORIDE

Glumetinib

GLUMETINIB (SCC244)

SCC244

1H-Pyrazolo[4,3-b]pyridine, 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-

Gumarontinib

6-(1-Methyl-1H-pyrazol-4-yl)-1-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)sulfonyl)-1H-pyrazolo[4,3-b]pyridine

SCC 244,proliferation,tumor,cancer,Glumetinib,bioavailable,oral,HCC,SCC-244,inhibit,c-Met/HGFR,ATP-competitive,cell,NSCLC,Inhibitor

Fenbuconazole Impurity 1

1642581-63-2

C21H17N9O2S