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Glumetinib

Product Name
Glumetinib
CAS No.
1642581-63-2
Chemical Name
Glumetinib
Synonyms
SCC244;Glumetinib;Gumarontinib;GLUMETINIB (SCC244);Fenbuconazole Impurity 1;Glumetinib, 10 mM in DMSO;6-(1-Methyl-1H-pyrazol-4-yl)-1-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)sulfonyl)-1H-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-;SCC 244,proliferation,tumor,cancer,Glumetinib,bioavailable,oral,HCC,SCC-244,inhibit,c-Met/HGFR,ATP-competitive,cell,NSCLC,Inhibitor
CBNumber
CB64667942
Molecular Formula
C21H17N9O2S
Formula Weight
459.48
MOL File
1642581-63-2.mol
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Glumetinib Property

Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
pka
0.09±0.10(Predicted)
color 
Beige
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28952
Product name
Glumetinib
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
28952
Product name
Glumetinib
Packaging
25mg
Price
$638
Updated
2024/03/01
Cayman Chemical
Product number
28952
Product name
Glumetinib
Packaging
5mg
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
28952
Product name
Glumetinib
Packaging
10mg
Price
$290
Updated
2024/03/01
AK Scientific
Product number
1891EF
Product name
Glumetinib
Packaging
10mg
Price
$421
Updated
2021/12/16
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Glumetinib Chemical Properties,Usage,Production

Description

Glumetinib (1642581-63-2) is a highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-Met kinase.? It induced tumor regression in MET-driven CDX (MKN-45, SNU-5, EBC-1) and PDX (4 NSCLC, 5 HCC) tumor models.

References

Ai et al. (2018), Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models; Cancer Res., 17 751

Glumetinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Glumetinib Suppliers

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View Lastest Price from Glumetinib manufacturers

Moxin Chemicals
Product
Glumetinib 1642581-63-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
100000
Release date
2025-03-18

1642581-63-2, GlumetinibRelated Search:

NOTUMib-1 BI 2536 Imiquimod NORFLUOXETINE HYDROCHLORIDE

  • Glumetinib
  • GLUMETINIB (SCC244)
  • SCC244
  • 1H-Pyrazolo[4,3-b]pyridine, 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-
  • Gumarontinib
  • 6-(1-Methyl-1H-pyrazol-4-yl)-1-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)sulfonyl)-1H-pyrazolo[4,3-b]pyridine
  • SCC 244,proliferation,tumor,cancer,Glumetinib,bioavailable,oral,HCC,SCC-244,inhibit,c-Met/HGFR,ATP-competitive,cell,NSCLC,Inhibitor
  • Fenbuconazole Impurity 1
  • Glumetinib, 10 mM in DMSO
  • 1642581-63-2
  • C21H17N9O2S