N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

Product Name: N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
CAS No.: 261766-23-8
Chemical Name: N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Synonyms: N-4AIA;N-4ACETIA;N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE;N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
CBNumber: CB6475024
Molecular Formula: C27H24ClN3O4
Formula Weight: 489.95
MOL File: Mol file

More

Less

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Property

Melting point:: 256-257°C
storage temp.: −20°C
solubility: DMSO: ≥15 mg/mL
form: crystalline
color: Pale Yellow

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 50mg
Price: $553
Updated: 2024/03/01

TRC

Product number: A161150
Product name: N-(4-Acetamidophenyl)indomethacinAmide
Packaging: 5mg
Price: $55
Updated: 2021/12/16

More

Less

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production

Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC₅₀ values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Chemical Properties

Pale Yellow Solid

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

Definition

ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Suppliers

Canada 1 China 10 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 21

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55896
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 8740
Advantage: 58

261766-23-8, N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDERelated Search:

5-METHOXY-2-METHYLINDOLE

N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE

N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

N-4ACETIA

N-4AIA

N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-

261766-23-8

C27H24N3O4Cl

C27H24ClN3O4

Biochemicals and Reagents

BioChemical

Application Index

Cell Signaling Enzymes

Cyclooxygenase Inhibitors

Cyclooxygenase (COX) Enzymes

Enzymes, Inhibitors, and Substrates

Inhibitors

Aromatics

Heterocycles