N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

Product Name: N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
CAS No.: 261766-23-8
Chemical Name: N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Synonyms: N-4AIA;N-4ACETIA;N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE;N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
CBNumber: CB6475024
Molecular Formula: C27H24ClN3O4
Formula Weight: 489.95
MOL File: Mol file

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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Property

Melting point:: 256-257°C
storage temp.: −20°C
solubility: DMSO: ≥15 mg/mL
form: crystalline
color: Pale Yellow

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 70278
Product name: N-(4-acetamidophenyl)-Indomethacin amide
Purity: ≥98%
Packaging: 50mg
Price: $553
Updated: 2024/03/01

TRC

Product number: A161150
Product name: N-(4-Acetamidophenyl)indomethacinAmide
Packaging: 5mg
Price: $55
Updated: 2021/12/16

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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production

Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC₅₀ values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Chemical Properties

Pale Yellow Solid

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

Definition

ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Suppliers

Canada 1 China 10 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 21

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261766-23-8, N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDERelated Search:

5-METHOXY-2-METHYLINDOLE

N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE

N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

N-4ACETIA

N-4AIA

N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-

261766-23-8

C27H24N3O4Cl

C27H24ClN3O4

Biochemicals and Reagents

BioChemical

Application Index

Cell Signaling Enzymes

Cyclooxygenase Inhibitors

Cyclooxygenase (COX) Enzymes

Enzymes, Inhibitors, and Substrates

Inhibitors

Aromatics

Heterocycles