2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile

ChemicalBook > CAS DataBase List > 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile

2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile

Synthesis

Product Name: 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
CAS No.: 93413-76-4
Chemical Name: 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
Synonyms: forVenlafaxine;Venlafaxine Cyano;Venlafaxine Impurity 15;Venlafaxine Impurity 28;VENLAFAXINE CYNO IMPURITY;Venlafaxine Cyano Impurity;Intermediate of Venlafaxine;Venlafaxine Nitrile Impurity;1-[Cyano-(4-Methoxyphenyl)Meth;D,L-VENLAFAXINE, HYDROCHLORIDE int
CBNumber: CB6476117
Molecular Formula: C15H19NO2
Formula Weight: 245.32
MOL File: 93413-76-4.mol

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2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Property

Melting point:: 121-123°C
Boiling point:: 410.1±25.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 13.80±0.20(Predicted)
color: White to Almost white
CAS DataBase Reference: 93413-76-4(CAS DataBase Reference)

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Safety

HS Code: 2926.90.4850

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1303
Product name: (1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $116
Updated: 2023/06/20

TCI Chemical

Product number: H1303
Product name: (1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $349
Updated: 2023/06/20

Biosynth Carbosynth

Product number: FC20603
Product name: 1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
Packaging: 25mg
Price: $254.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20603
Product name: 1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
Packaging: 10mg
Price: $139.8
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20603
Product name: 1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
Packaging: 50mg
Price: $462
Updated: 2021/12/16

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2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Chemical Properties,Usage,Production

Synthesis

A mixture of p-methoxyphenylacetonitrile 36 (100 g, 0.68 mol), 10% aqueous NaOH solution (100 ml, 0.25 mol) and TBAHSO4 (5 g, 0.014 mol) was stirred at room temperature for 30 minutes. A dark red colour appeared. To this was added cyclohexanone 34 (67 g, 0.680 mol) in small portions at 0 ºC, with vigorous stirring, in such a way that temperature should not rise above 10 ºC. A white solid was formed within 30 minutes to one hour. The solid was crushed and the reaction mixture was further stirred vigorously at room temperature for one more hour. The solid was filtered, washed with water till neutral to pH paper and air-dried. Crystallization from ethyl acetatepetroleum ether (500:350, v/v) gave a bright white solid (161.66 g).

Chemical Properties

White Powder

Uses

An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine

2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile manufacturers

Career Henan Chemical Co

Product: 1-[Cyano-(p-methoxyphenyl)methyl]cyclohexanol 93413-76-4
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

93413-76-4, 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)AcetonitrileRelated Search:

4-Methoxyphenylacetic acid (3,4-Dimethoxyphenyl)acetonitrile Methanol Cyclohexanol (3-Methoxyphenyl)acetonitrile Methyl acrylate Acetonitrile Benzeneacetonitrile Vinyltrimethoxysilane Methylparaben Basic Violet 1 Diphenylacetonitrile 4-Methoxybenzyl cyanide Kresoxim-methyl Paraquat dichloride 4-BROMO-2,2-DIPHENYLBUTYRONITRILE rac N,N-DidesMethyl-N-(4-hydroxyphenethyl)-O-desMethyl Venlafaxine (2RS)-2-Cyclohexyl-2-(4-Methoxyphenyl)-N,NdiMethylethanaMineHydrochloride

alpha-(1-Hydroxycyclohexyl)-4-methoxybenzeneacetonitrile

1-(Hydroxycyclohexyl)-(4-Methoxyphenly)Acetonitrlle

1-[(1-CYANO)-1-(4-METHOXYPHENYL)METHYL]CYCLODEXANOL

1-[Cyno-(4-Methoxyphenyl)Methyl]Cyclohexanol(Vf1)

1-HydroxyCyclohexyl-4-MethoxyPhenylAcetonitrile(ForVenlafaxineHcl)

forVenlafaxine

1-(cyclohexanol)-(4methoxyphenyl)acetonitrile

Intermediate of Venlafaxine

1-[Cyano-(4-Methoxyphenyl)Meth

1-(hydroxycyclohexyl)-(4-methoxyphenyl)acetonitrile (intermediate of venlafaxine)

1-hydroxy cyclohexyl-4-methoxy phenyl acetonitrile (intermediate of venlafaxine hcl)

1-[CYANO-(4-METHOXYPHENYL)METHYL]CYCLOHEXANOL[FOR VENLAFAXINE HCL]

4-Methoxy benzyl cyano cyclohexanol

1-(p-Methoxyphenyl-cyano)-methylcyclohexanol

α-(1-Hydroxycyclohexyl)-4-Methoxy-benzeneacetonitrile

α-(p-Methoxyphenyl)-α-(1-hydroxycyclohexyl)acetonitrile

Venlafaxine Hydroxy Nitrile Impurity

Venlafaxine Cyano Impurity

Venlafaxine hydroxynitrile impurities

Venlafaxine Nitrile Impurity

Venlafaxine Impurity 3 (Venlafaxine Hydroxy Nitrile Impurity)

D,L-VENLAFAXINE, HYDROCHLORIDE int

3-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)propanenitrile

1-[(1-CYANO)-1-(4-METHOXYPHENYL)METHYL] CYCLOHEXANOL

1-[CYANO-(P-METHOXYPHENYL)METHYL]CYCLOHEXANOL

1-(CYANO-(4-METHOXY PHENYL) METHYL) CYCLOHEXANOL

Venlafaxine Impurity 15

(1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile&gt

Benzeneacetonitrile, α-(1-hydroxycyclohexyl)-4-methoxy-

1-(HYDROXYCYCLOHEXY)-(4-METHOXYPHENLY)ACETONITRLLE

1- [Cyano (P- Methoxyphenyl) Methyl] Cyclohexanol: VNF Stage-I

Venlafaxine Impurity 28

2-(1-Hydroxycyclohexyl)-2-(4-methoxypheny)acetonitrile

2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile

1-[Cyano-(4-methoxyphenyl)methyl] cyclohexanol (VENLA-I)

Benzeneacetonitrile, α-(1-hydroxycyclohexyl)-4-methoxy-

Venlafaxine Cyano

(1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile, ≥ 98.0%

VENLAFAXINE CYNO IMPURITY

93413-76-4

C15H19O2N

Medicine intermediate

Nitriles

API intermediates

(intermediate of venlafaxine)

(intermediate of venlafaxine hcl)

Intermediates & Fine Chemicals

Pharmaceuticals