Synthesis
ChemicalBook > CAS DataBase List > 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile

2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile

Synthesis
Product Name
2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
CAS No.
93413-76-4
Chemical Name
2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
Synonyms
forVenlafaxine;Venlafaxine Cyano;Venlafaxine Impurity 15;Venlafaxine Impurity 28;VENLAFAXINE CYNO IMPURITY;Venlafaxine Cyano Impurity;Intermediate of Venlafaxine;Venlafaxine Nitrile Impurity;1-[Cyano-(4-Methoxyphenyl)Meth;D,L-VENLAFAXINE, HYDROCHLORIDE int
CBNumber
CB6476117
Molecular Formula
C15H19NO2
Formula Weight
245.32
MOL File
93413-76-4.mol
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2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Property

Melting point:
121-123°C
Boiling point:
410.1±25.0 °C(Predicted)
Density 
1.142±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
13.80±0.20(Predicted)
color 
White to Almost white
CAS DataBase Reference
93413-76-4(CAS DataBase Reference)
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Safety

HS Code 
2926.90.4850
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1303
Product name
(1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$116
Updated
2023/06/20
TCI Chemical
Product number
H1303
Product name
(1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$349
Updated
2023/06/20
Biosynth Carbosynth
Product number
FC20603
Product name
1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
Packaging
25mg
Price
$254.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20603
Product name
1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
Packaging
10mg
Price
$139.8
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20603
Product name
1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
Packaging
50mg
Price
$462
Updated
2021/12/16
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2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Chemical Properties,Usage,Production

Synthesis

A mixture of p-methoxyphenylacetonitrile 36 (100 g, 0.68 mol), 10% aqueous NaOH solution (100 ml, 0.25 mol) and TBAHSO4 (5 g, 0.014 mol) was stirred at room temperature for 30 minutes. A dark red colour appeared. To this was added cyclohexanone 34 (67 g, 0.680 mol) in small portions at 0 ºC, with vigorous stirring, in such a way that temperature should not rise above 10 ºC. A white solid was formed within 30 minutes to one hour. The solid was crushed and the reaction mixture was further stirred vigorously at room temperature for one more hour. The solid was filtered, washed with water till neutral to pH paper and air-dried. Crystallization from ethyl acetatepetroleum ether (500:350, v/v) gave a bright white solid (161.66 g).

Chemical Properties

White Powder

Uses

An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine

2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Suppliers

Americas 1 Canada 1 China 147 Europe 3 Germany 3 India 70 Japan 2 South Korea 1 Ukraine 1 United Kingdom 8 United States 23 Global 260
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Hattori Corporation
Tel
--
Fax
--
Email
info@hattoricorp.com
Country
Japan
ProdList
1254
Advantage
58
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View Lastest Price from 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile manufacturers

Career Henan Chemical Co
Product
1-[Cyano-(p-methoxyphenyl)methyl]cyclohexanol 93413-76-4
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

93413-76-4, 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)AcetonitrileRelated Search:

4-Methoxyphenylacetic acid (3,4-Dimethoxyphenyl)acetonitrile Methanol Cyclohexanol (3-Methoxyphenyl)acetonitrile Methyl acrylate Acetonitrile Benzeneacetonitrile Vinyltrimethoxysilane Methylparaben Basic Violet 1 Diphenylacetonitrile 4-Methoxybenzyl cyanide Kresoxim-methyl Paraquat dichloride 4-BROMO-2,2-DIPHENYLBUTYRONITRILE rac N,N-DidesMethyl-N-(4-hydroxyphenethyl)-O-desMethyl Venlafaxine (2RS)-2-Cyclohexyl-2-(4-Methoxyphenyl)-N,NdiMethylethanaMineHydrochloride

  • alpha-(1-Hydroxycyclohexyl)-4-methoxybenzeneacetonitrile
  • 1-(Hydroxycyclohexyl)-(4-Methoxyphenly)Acetonitrlle
  • 1-[(1-CYANO)-1-(4-METHOXYPHENYL)METHYL]CYCLODEXANOL
  • 1-[Cyno-(4-Methoxyphenyl)Methyl]Cyclohexanol(Vf1)
  • 1-HydroxyCyclohexyl-4-MethoxyPhenylAcetonitrile(ForVenlafaxineHcl)
  • forVenlafaxine
  • 1-(cyclohexanol)-(4methoxyphenyl)acetonitrile
  • Intermediate of Venlafaxine
  • 1-[Cyano-(4-Methoxyphenyl)Meth
  • 1-(hydroxycyclohexyl)-(4-methoxyphenyl)acetonitrile (intermediate of venlafaxine)
  • 1-hydroxy cyclohexyl-4-methoxy phenyl acetonitrile (intermediate of venlafaxine hcl)
  • 1-[CYANO-(4-METHOXYPHENYL)METHYL]CYCLOHEXANOL[FOR VENLAFAXINE HCL]
  • 4-Methoxy benzyl cyano cyclohexanol
  • 1-(p-Methoxyphenyl-cyano)-methylcyclohexanol
  • α-(1-Hydroxycyclohexyl)-4-Methoxy-benzeneacetonitrile
  • α-(p-Methoxyphenyl)-α-(1-hydroxycyclohexyl)acetonitrile
  • Venlafaxine Hydroxy Nitrile Impurity
  • Venlafaxine Cyano Impurity
  • Venlafaxine hydroxynitrile impurities
  • Venlafaxine Nitrile Impurity
  • Venlafaxine Impurity 3 (Venlafaxine Hydroxy Nitrile Impurity)
  • D,L-VENLAFAXINE, HYDROCHLORIDE int
  • 3-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)propanenitrile
  • 1-[(1-CYANO)-1-(4-METHOXYPHENYL)METHYL] CYCLOHEXANOL
  • 1-[CYANO-(P-METHOXYPHENYL)METHYL]CYCLOHEXANOL
  • 1-(CYANO-(4-METHOXY PHENYL) METHYL) CYCLOHEXANOL
  • Venlafaxine Impurity 15
  • (1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile&gt
  • Benzeneacetonitrile, α-(1-hydroxycyclohexyl)-4-methoxy-
  • 1-(HYDROXYCYCLOHEXY)-(4-METHOXYPHENLY)ACETONITRLLE
  • 1- [Cyano (P- Methoxyphenyl) Methyl] Cyclohexanol: VNF Stage-I
  • Venlafaxine Impurity 28
  • 2-(1-Hydroxycyclohexyl)-2-(4-methoxypheny)acetonitrile
  • 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
  • 1-[Cyano-(4-methoxyphenyl)methyl] cyclohexanol (VENLA-I)
  • Benzeneacetonitrile, α-(1-hydroxycyclohexyl)-4-methoxy-
  • Venlafaxine Cyano
  • (1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile, ≥ 98.0%
  • VENLAFAXINE CYNO IMPURITY
  • 93413-76-4
  • C15H19O2N
  • Medicine intermediate
  • Nitriles
  • API intermediates
  • (intermediate of venlafaxine)
  • (intermediate of venlafaxine hcl)
  • Intermediates & Fine Chemicals
  • Pharmaceuticals