DSIP

ChemicalBook > CAS DataBase List > DSIP

Product Name: DSIP
CAS No.: 62568-57-4
Chemical Name: DSIP
Synonyms: DSIP;WAGGDASGE;DSIP 4H2O;EMIDELTIDE;Delta-Sleep;DSIP acetate;Etipolypeptide;DSIP USP/EP/BP;Ftpp/Adipotide;DSIP nonapeptide
CBNumber: CB6478191
Molecular Formula: C35H48N10O15
Formula Weight: 848.82
MOL File: 62568-57-4.mol

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DSIP Property

Boiling point:: 1522.7±65.0 °C(Predicted)
Density: 1.458±0.06 g/cm3(Predicted)
storage temp.: −20°C
form: Powder
pka: 3.18±0.10(Predicted)
color: White to off-white
Water Solubility: Soluble in water at 0.5mg/ml
Sequence: H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
InChI: InChI=1/C35H48N10O15/c1-16(41-32(56)20(36)9-18-11-37-21-6-4-3-5-19(18)21)30(54)39-12-25(47)38-13-26(48)44-23(10-29(52)53)34(58)42-17(2)31(55)45-24(15-46)33(57)40-14-27(49)43-22(35(59)60)7-8-28(50)51/h3-6,11,16-17,20,22-24,37,46H,7-10,12-15,36H2,1-2H3,(H,38,47)(H,39,54)(H,40,57)(H,41,56)(H,42,58)(H,43,49)(H,44,48)(H,45,55)(H,50,51)(H,52,53)(H,59,60)/t16-,17-,20-,22-,23-,24-/s3
InChIKey: ZRZROXNBKJAOKB-GFVHOAGBSA-N
SMILES: C(C1=CNC2C=CC=CC1=2)[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)O)CCC(=O)O |&1:10,15,28,36,41,51,r|

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D4072
Product name: Delta Sleep Inducing Peptide
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: D4072
Product name: Delta Sleep Inducing Peptide
Packaging: 25mg
Price: $218.4
Updated: 2024/03/01

Alfa Aesar

Product number: J63334
Product name: Delta Sleep-Inducing Peptide
Packaging: 1mg
Price: $34.5
Updated: 2021/12/16

Alfa Aesar

Product number: J63334
Product name: Delta Sleep-Inducing Peptide
Packaging: 5mg
Price: $118
Updated: 2021/12/16

Usbiological

Product number: D2732-01B
Product name: Delta Sleep Inducing Peptide
Packaging: 25mg
Price: $809
Updated: 2021/12/16

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DSIP Chemical Properties,Usage,Production

Description

Delta-sleep-inducing peptide (DSIP) is a neuropeptide with amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and molecular mass 848.81 g/mol. DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). Delta-sleep-inducing peptide is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

Uses

Delta-sleep-inducing peptide (DSIP) was isolated, characterized, and synthesized more than 6 years ago. It can help relieve stress and aches that keep you from restful sleep. It was first proposed as a sleep-peptide and this remains the prevalent impression of its function. DSIP is a natural sleep-promoting nonapeptide with a few beneficial functions. The peptide has been used to treat poor sleep, pain conditions, stress-related symptoms, and more. Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt is a useful research chemical compound.

Uses

DSIP is thought to increase sleep regulation, reduce motor activity to improve deep sleep, stimulate ACTH and LH levels, and reportedly normalize blood pressure. DSIP can change the serum level of some hormones, such as adrenocorticotropic hormone, somatostatin, serotonin, etc.

Definition

Emideltide or DSIP is a nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals. In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.

benefits

Can restore disturbed sleep patterns;Can promote LH and GH release;Can reduce persistent/chronic pain;Can modulate cortisol production.

benefits

Delta sleep-inducing peptide (DSIP), which suppresses excess production of free radicals in the CNS and prevents neuron death during the body’s response to stress. DSIP activates oxidative phosphorylation and increases the resistance of brain neurons to hypoxia in vitro. It decreases the sensitivity of neuron receptors to the excitatory actions of glutamate. Thus, DSIP helps to prevent excitotoxicity, which may underlie its neuroprotective action in cerebral ischemia[1].

References

[1] E. Koplik. “Delta sleep-inducing peptide and Deltaran: Potential approaches to antistress protection.” Neuroscience and Behavioral Physiology 38 1 (2008): 953–957.

Physiological effects

Delta sleep-inducing peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals. It is also involved in neuroendocrine regulation and release of anterior pituitary hormones. In rodents and humans, Delta sleep-inducing peptide (DSIP) influence in the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of the circadian rhythms and and can help restore disturbed patterns of sleep.

DSIP Preparation Products And Raw materials

Raw materials

Preparation Products

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DSIP Suppliers

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View Lastest Price from DSIP manufacturers

Dorne Chemical Technology co. LTD

Product: DSIP 62568-57-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Shandong Huizhihan Supply Chain Co., Ltd

Product: DSIP 62568-57-4
Price: US $0.00-0.00/box
Min. Order: 1box
Purity: 99.99%
Supply Ability: 10000
Release date: 2024-10-29

CONTIDE BIOTECH CO.,LTD

Product: DSIP 62568-57-4
Price: US $0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 20
Release date: 2024-10-17

62568-57-4, DSIPRelated Search:

Ipamorelin Eptifibatide Acetate Vantas Elamipretide DSIP N-Acetyl-L-glutamic acid Delta Sleep Inducing Peptide [Tyr0] (DSIP) DSIP (PHOSPHO),PHOSPHO-DSIP H-GLY-GLY-GLU-OH Delta Sleep Inducing Peptide, phosphorylated (DSIP) Delta Sleep Inducing Peptide (DSIP) [Trp-Ala-Gly-Gly-Asp(Ala-Ser-Gly-Glu-OH)-OH] Delta Sleep Inducing Peptide (DSIP) [Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu] Delta Sleep Inducing Peptide (DSIP) 4-Ala-dsip-NH2 (TYR1)-DSIP (ASN5)-DSIP Delta Sleep Inducing Peptide (DSIP) [Trp-Ala-Gly-Gly-Asp(Ala-Ser-Gly-Glu-OH)-NH2] Delta Sleep Inducing Peptide (DSIP), Rabbit anti-

SLEEP INDUCING PEPTIDE

WAGGDASGE

TRP-ALA-GLY-GLY-ASN-ALA-SER-GLY-GLU

TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU

TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU 4H2O

DELTA SLEEP INDUCING PEPTIDE

DELTA SLEEP-INDUCING PEPTIDE 4H2O

DSIP

DSIP 4H2O

H-TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU-OH

EMIDELTIDE

TRP-ALA---ASP-ALA-SER--GLU(TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU)

DSIP, Sleep inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-Glu-OH

L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-L-Glu-OH

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH

TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE]

DSIP nonapeptide

L-Tryptophyl-L-alanylglycylglycyl-L-alpha-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid

DSIP, EMideltide

Delta sleep inducing peptide, ≥97% (HPLC)

DSIP/Delta Sleep Inducing Peptide

Deltasleep-inducing peptide (rabbit)

Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt

Etipolypeptide

DSIP USP/EP/BP

Ftpp/Adipotide

DSIP acetate

Emideltide (δ-Sleep Inducing Peptide)

Delta-Sleep

DSIP Lyophilized Powder

Delta Sleep Inducing Peptide Acetate

δ-Sleep Inducing Peptide acetate

62568-57-4

9431-45-4

C35H48N10O15

Peptide

62568-57-4