Dolutegravir 2-Desfluoro Impurity

Product Name: Dolutegravir 2-Desfluoro Impurity
CAS No.: 1863916-88-4
Chemical Name: Dolutegravir 2-Desfluoro Impurity
Synonyms: 4-Fluoro Dolutegravir;Dolutegravir Impurity G;Dolutegravir Impurity 50;Dolutegravir Impurity 47;Defluoro Dolutegravir (>85%);Dolutegravir 4-Fluoro Impurity;Dolutegravir 2-Desfluoro Impurity;(4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity
CBNumber: CB64796145
Molecular Formula: C20H20FN3O5
Formula Weight: 401.39
MOL File: 1863916-88-4.mol

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Dolutegravir 2-Desfluoro Impurity Property

Boiling point:: 675.7±55.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 4.50±1.00(Predicted)
color: Off-White to Light Brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D228715
Product name: DefluoroDolutegravir
Packaging: 10mg
Price: $1080
Updated: 2021/12/16

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Dolutegravir 2-Desfluoro Impurity Chemical Properties,Usage,Production

Uses

Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir 2-Desfluoro Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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1863916-88-4, Dolutegravir 2-Desfluoro ImpurityRelated Search:

Dolutegravir 4-Desfluoro Impurity IMpurity of Dolutegravir GSK1349572 Dolutegravir Impurity 3 Dolutegravir sodium Dolutegravir Impurity 6 O-Methyl Dolutegravir

2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity

Dolutegravir impurity 4/Defluoro Dolutegravir/(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

Dolutegravir Impurity G

Dolutegravir 2-Desfluoro Impurity

2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-

(4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

Dolutegravir Impurity 47

Dolutegravir Impurity 50

4-Fluoro Dolutegravir

Dolutegravir 4-Fluoro Impurity

Defluoro Dolutegravir (>85%)

1863916-88-4