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Dolutegravir 2-Desfluoro Impurity

Product Name
Dolutegravir 2-Desfluoro Impurity
CAS No.
1863916-88-4
Chemical Name
Dolutegravir 2-Desfluoro Impurity
Synonyms
4-Fluoro Dolutegravir;Dolutegravir Impurity G;Dolutegravir Impurity 50;Dolutegravir Impurity 47;Dolutegravir 4-Fluoro Impurity;Dolutegravir 2-Desfluoro Impurity;(4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity;Dolutegravir impurity 4/Defluoro Dolutegravir/(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CBNumber
CB64796145
Molecular Formula
C20H20FN3O5
Formula Weight
401.39
MOL File
1863916-88-4.mol
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Dolutegravir 2-Desfluoro Impurity Property

Boiling point:
675.7±55.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
4.50±1.00(Predicted)
color 
Off-White to Light Brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D228715
Product name
DefluoroDolutegravir
Packaging
10mg
Price
$1080
Updated
2021/12/16
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Dolutegravir 2-Desfluoro Impurity Chemical Properties,Usage,Production

Uses

Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir 2-Desfluoro Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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Dolutegravir 2-Desfluoro Impurity Suppliers

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1863916-88-4, Dolutegravir 2-Desfluoro ImpurityRelated Search:


  • 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity
  • Dolutegravir impurity 4/Defluoro Dolutegravir/(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • Dolutegravir Impurity G
  • Dolutegravir 2-Desfluoro Impurity
  • 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
  • (4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • Dolutegravir Impurity 47
  • Dolutegravir Impurity 50
  • 4-Fluoro Dolutegravir
  • Dolutegravir 4-Fluoro Impurity
  • 1863916-88-4