ChemicalBook > CAS DataBase List > Belvarafenib

Belvarafenib

Product Name
Belvarafenib
CAS No.
1446113-23-0
Chemical Name
Belvarafenib
Synonyms
RG6185;GDC5573;HM95573;RG 6185;RG-6185;HM 95573;GDC-5573;GDC 5573;HM-95573;Belvarafenib
CBNumber
CB64806091
Molecular Formula
C23H16ClFN6OS
Formula Weight
478.93
MOL File
1446113-23-0.mol
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Belvarafenib Property

Boiling point:
609.6±55.0 °C(Predicted)
Density 
1.562±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO:46.17(Max Conc. mg/mL);96.4(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.64(Max Conc. mM)
form 
A crystalline solid
pka
11.16±0.43(Predicted)
color 
Off-white to yellow
InChIKey
KVCQTKNUUQOELD-UHFFFAOYSA-N
SMILES
C1=NC(N)=C2SC=C(C(NC3=C(C)C=CC4=C3C=CN=C4NC3=CC=CC(Cl)=C3F)=O)C2=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon3067
Product name
Belvarafenib-GDC-5573|HM95573
Purity
99%
Packaging
5mg
Price
$126.5
Updated
2021/12/16
ChemScene
Product number
CS-0039257
Product name
Belvarafenib
Purity
98.05%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0039257
Product name
Belvarafenib
Purity
98.05%
Packaging
10mg
Price
$310
Updated
2021/12/16
ChemScene
Product number
CS-0039257
Product name
Belvarafenib
Purity
98.05%
Packaging
50mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0039257
Product name
Belvarafenib
Purity
98.05%
Packaging
100mg
Price
$1950
Updated
2021/12/16
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Belvarafenib Chemical Properties,Usage,Production

Uses

Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].

IC 50

BRafV600E: 7 nM (IC50); CRAF: 5 nM (IC50); B-Raf: 56 nM (IC50)

References

[1] WO 2013/100632 A1.

Belvarafenib Preparation Products And Raw materials

Raw materials

Preparation Products

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Belvarafenib Suppliers

China 69 United States 6 Global 75
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View Lastest Price from Belvarafenib manufacturers

Henan Fengda Chemical Co., Ltd
Product
Belvarafenib 1446113-23-0
Price
US $8.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28

1446113-23-0, BelvarafenibRelated Search:

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