1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE

Product Name: 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
CAS No.: 162054-19-5
Chemical Name: 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
Synonyms: SC-58125;1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole;5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-;Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit
CBNumber: CB6486473
Molecular Formula: C17H12F4N2O2S
Formula Weight: 384.35
MOL File: 162054-19-5.mol

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1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Property

storage temp.: Store at +4°C
solubility: DMSO: ≥20mg/mL
form: powder
color: white to off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45-24/25-22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0139
Product name: SC-58125
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0139
Product name: SC-58125
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $404
Updated: 2024/03/01

Cayman Chemical

Product number: 70655
Product name: SC-58125
Purity: ≥98%
Packaging: 1mg
Price: $17
Updated: 2024/03/01

Cayman Chemical

Product number: 70655
Product name: SC-58125
Purity: ≥98%
Packaging: 5mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 70655
Product name: SC-58125
Purity: ≥98%
Packaging: 10mg
Price: $118
Updated: 2024/03/01

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1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor with anti-inflammatory properties. SC-58125 blocks edema and hyperalgesia without causing gastric mucosal damage. SC-58125 also displays anti tumor activity.

Definition

ChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor it exhibits anticancer property.

Biological Activity

Selective cyclooxygenase 2 (COX-2) inhibitor (IC 50 values are 0.04 and >100 μ M for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.

1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Suppliers

Canada 1 China 38 India 1 Switzerland 1 United Kingdom 4 United States 10 Global 55

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162054-19-5, 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLERelated Search:

2-Methylindole Octadecyl methacrylate (S)-(+)-Benzyl glycidyl ether 2-Methylpropanedioic acid p-Tolualdehyde 4'-Hydroxyacetophenone 3-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE 3-(4-Fluorophenyl)-1H-pyrazole 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE 5-(TRIFLUOROMETHYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE 1,5-DIPHENYL-3-METHYL-1H-PYRAZOLE 3-DIFLUOROMETHYL-5-PHENYLPYRAZOLE 1,5-DIPHENYL-3-TRIFLUOROMETHYL-1H-PYRAZOLE 3-TRIFLUOROMETHYL-5-METHYL-1-(PHENYL)PYRAZOLE 5-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE

SC-58125

1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE

5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole

5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole

5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole

1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-

Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit

162054-19-5

C17H12F4N2O2S