ChemicalBook > CAS DataBase List > 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE

1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE

Product Name
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
CAS No.
162054-19-5
Chemical Name
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
Synonyms
SC-58125;1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole;5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-;Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit
CBNumber
CB6486473
Molecular Formula
C17H12F4N2O2S
Formula Weight
384.35
MOL File
162054-19-5.mol
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1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Property

storage temp. 
Store at +4°C
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25-22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0139
Product name
SC-58125
Purity
≥98% (HPLC)
Packaging
5mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0139
Product name
SC-58125
Purity
≥98% (HPLC)
Packaging
25mg
Price
$404
Updated
2024/03/01
Cayman Chemical
Product number
70655
Product name
SC-58125
Purity
≥98%
Packaging
1mg
Price
$17
Updated
2024/03/01
Cayman Chemical
Product number
70655
Product name
SC-58125
Purity
≥98%
Packaging
5mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
70655
Product name
SC-58125
Purity
≥98%
Packaging
10mg
Price
$118
Updated
2024/03/01
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1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor with anti-inflammatory properties. SC-58125 blocks edema and hyperalgesia without causing gastric mucosal damage. SC-58125 also displays anti tumor activity.

Definition

ChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor it exhibits anticancer property.

Biological Activity

Selective cyclooxygenase 2 (COX-2) inhibitor (IC 50 values are 0.04 and >100 μ M for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.

1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Suppliers

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162054-19-5, 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLERelated Search:

2-Methylindole Octadecyl methacrylate (S)-(+)-Benzyl glycidyl ether 2-Methylpropanedioic acid p-Tolualdehyde 4'-Hydroxyacetophenone 3-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE 3-(4-Fluorophenyl)-1H-pyrazole 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE 5-(TRIFLUOROMETHYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE 1,5-DIPHENYL-3-METHYL-1H-PYRAZOLE 3-DIFLUOROMETHYL-5-PHENYLPYRAZOLE 1,5-DIPHENYL-3-TRIFLUOROMETHYL-1H-PYRAZOLE 3-TRIFLUOROMETHYL-5-METHYL-1-(PHENYL)PYRAZOLE 5-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE

  • SC-58125
  • 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
  • 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole
  • 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole
  • 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
  • 1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-
  • Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit
  • 162054-19-5
  • C17H12F4N2O2S