1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
- Product Name
- 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
- CAS No.
- 162054-19-5
- Chemical Name
- 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
- Synonyms
- SC-58125;1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole;5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-;Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit
- CBNumber
- CB6486473
- Molecular Formula
- C17H12F4N2O2S
- Formula Weight
- 384.35
- MOL File
- 162054-19-5.mol
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Property
- storage temp.
- Store at +4°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- white to off-white
Safety
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45-24/25-22
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PZ0139
- Product name
- SC-58125
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- PZ0139
- Product name
- SC-58125
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $404
- Updated
- 2024/03/01
- Product number
- 70655
- Product name
- SC-58125
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $17
- Updated
- 2024/03/01
- Product number
- 70655
- Product name
- SC-58125
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 70655
- Product name
- SC-58125
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $118
- Updated
- 2024/03/01
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor with anti-inflammatory properties. SC-58125 blocks edema and hyperalgesia without causing gastric mucosal damage. SC-58125 also displays anti tumor activity.
Definition
ChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor it exhibits anticancer property.
Biological Activity
Selective cyclooxygenase 2 (COX-2) inhibitor (IC 50 values are 0.04 and >100 μ M for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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