ChemicalBook > CAS DataBase List > Triamcinolone diacetate

Triamcinolone diacetate

Product Name
Triamcinolone diacetate
CAS No.
67-78-7
Chemical Name
Triamcinolone diacetate
Synonyms
TAC-D;8357RP;CINO-40;Tedarol;Cenacort;Tracilon;Kenacourt;21-diacetate;Triamolone 40;aristocortsyrup
CBNumber
CB6488260
Molecular Formula
C25H31FO8
Formula Weight
478.51
MOL File
67-78-7.mol
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Triamcinolone diacetate Property

Melting point:
186-188 C
alpha 
D25 +22° (chloroform)
Boiling point:
608.5±55.0 °C(Predicted)
Density 
1.2087 (estimate)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
pka
11.21±0.70(Predicted)
form 
Solid
color 
White
Water Solubility 
48mg/L(25 ºC)
CAS DataBase Reference
67-78-7(CAS DataBase Reference)
NIST Chemistry Reference
Triamcinolone diacetate(67-78-7)
EPA Substance Registry System
Triamcinolone diacetate (67-78-7)
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Safety

WGK Germany 
3
HS Code 
2937220000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1678005
Product name
Triamcinolone diacetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
350mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
T3676
Product name
Triamcinolone Diacetate
Packaging
50MG
Price
$74
Updated
2024/03/01
TCI Chemical
Product number
T3676
Product name
Triamcinolone Diacetate
Packaging
250MG
Price
$219
Updated
2024/03/01
TRC
Product number
T767170
Product name
Triamcinolone16,21-Diacetate
Packaging
250mg
Price
$1295
Updated
2021/12/16
TRC
Product number
T767170
Product name
Triamcinolone16,21-Diacetate
Packaging
25mg
Price
$160
Updated
2021/12/16
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Triamcinolone diacetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Aristocort,Lederle,US,1959

Uses

A glucocorticoid that inhibits prolyl hydroxylase activity and used as an antiasthmatic and antiallergic drug.

Uses

antiinflammatory

Uses

A glucocorticoid that inhibits prolyl hydroxylase activity, Triamcinolone diacetate can be used as an antiasthmatic and antiallergic drug.

Definition

ChEBI: Triamcinolone diacetate is a corticosteroid hormone.

Manufacturing Process

To a solution of 16α,21-diacetoxy-11β,17α-dihydroxy-9α-fluoro-4-pregnene- 3,20-dione (1.0 g) in tertiary-butanol (160 ml) and glacial acetic acid (1.6 ml) was added 600 mg of selenium dioxide, the mixture swept with nitrogen and kept at 70°C for 24 hours, selenium dioxide (350 mg) added, and the mixture swept with nitrogen and allowed to stand for another 24 hours. The reaction mixture was filtered, and the filtrate was evaporated to dryness under reduced pressure. The material so obtained was dissolved in ethyl acetate, washed with saturated sodium bicarbonate, water, cold freshly prepared ammonium sulfide solution, cold dilute ammonia water, cold dilute hydrochloric acid, and finally with water. After treatment with anhydrous sodium sulfate and activated charcoal, filtration through diatomaceous earth and evaporation to dryness under reduced pressure, 850 mg of a tan glass was obtained. Paper strip chromatographic analysis showed predominantly product plus a small amount of starting material. The 850 mg was chromatographed on 320 g of diatomaceous earth containing 160 ml of stationary phase of a solvent system composed of 3,4,3,2-ethyl acetate-petroleum ether (boiling point 90°C to 100°C), methanol, and water, respectively. The column dimensions were 3.8 cm x 78 cm with 460 ml hold back volume. The fifth and sixth hold back volumes were combined and evaporated under reduced pressure to 250 mg of product which, after a single crystallization from acetone petroleum ether, gave 173 mg, melting point 150°C to 190°C. Paper strip chromatography showed a single spot having the same polarity as an authentic sample of 16α,21-diacetoxy-11β,17α-dihydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione. A further crystallization from the same solvent pair gave 134 mg, melting point 185°C to 189°C, bubbles to 230°C.

Therapeutic Function

Glucocorticoid

Safety Profile

An experimental teratogen. Whenheated to decomposition it emits toxic fumes of F-.

Triamcinolone diacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Triamcinolone diacetate Suppliers

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View Lastest Price from Triamcinolone diacetate manufacturers

Hebei shuoxi biotechnology co. LTD
Product
Triamcinolone diacetate 67-78-7
Price
US $50.00/KG
Min. Order
10g
Purity
99.8%
Supply Ability
10tons
Release date
2019-11-06
Career Henan Chemical Co
Product
Triamcinolone diacetate 67-78-7
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

67-78-7, Triamcinolone diacetateRelated Search:

Isopropyl acetate 1-Methoxy-2-propyl acetate Ethylene glycol monoethyl ether acetate 2-Butoxyethyl acetate Triamcinolone Pancuronium bromide 9E,12Z-Tetradecadien-1-yl-acetate Isoflupredone 4-ACETOXY-2-BUTANONE TECH. 90 TRANS-2-FLUOROCYCLOHEXANOL CIS-1,2-CYCLOPENTANEDIOL Descinolone 3-METHYL-1,2-CYCLOPENTANEDIOL FLUOROCYCLOHEXANE (1-FLUOROCYCLOHEXYL)METHANOL FEMA 2348 Fluorine Z,E-9,12-TETRADECADIEN-1-OL

  • (11beta,16alpha)-16,21-Bis(acetyloxy)-9-fluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione
  • 16-(Acetyloxy)-9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
  • 21-diacetate
  • 9-alpha-Fluoro-16-alpha-hydroxyprednisolone diacetate
  • 9-alpha-fluoro-16-alpha-hydroxyprednisolonediacetate
  • 9-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,21-diacetate
  • 9-fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione16,21
  • Aristocort diacetate
  • Aristocort forte parenteral
  • Aristocort syrup
  • aristocortdiacetate
  • Triamcinolone Impurity 7
  • aristocortforteparenteral
  • aristocortsyrup
  • Cenacort
  • CINO-40
  • Kenacort diacetate syrup
  • kenacortdiacetatesyrup
  • Pregna-1,4-diene-2,20-dione, 9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, 16,21-diacetate
  • pregna-1,4-diene-2,20-dione,9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-,16,
  • Pregna-1,4-diene-3,20-dione, 16,21-bis(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11beta,16alpha)-
  • TAC-D
  • Tracilon
  • Triamcinolone 16,21-diacetate
  • Triamolone 40
  • TRIAMCINOLONE DIACETATE
  • TRIAMCINOLONE ACETATE
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,21-DIACETATE
  • 16a,21-diacetoxy-9a-fluoro-11b,17a-dihydroxy-1,4-pregnadiene-3,20-dione
  • 9-ALPHA-FLUORO-16-ALPHA-HYDROXYPREDNISOLONE 16,21-DIACETATE
  • 9-ALPHA-FLUORO-11-BETA,16-ALPHA,17-ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,21-DIACETATE
  • 9a-fluoro-16a-hydroxyprednisolone 16,21-diacetate
  • TRIAMCINOLONEDIACETATE,MICRONIZED,USP
  • 16a-Hydroxy-9a-fluoroprednisolone diacetate
  • 8357RP
  • 9a-Fluoro-1,4-pregnadiene-11b,16a,17a,21-tetraol-3,20-dione 16,21-diacetate
  • 9-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,21-diacetate
  • Aristocort diacetate forte
  • Aristocort diacetate parenteral
  • Aristocort Forte
  • Aristocort Parenterals
  • D1-16a-Hydroxy-9a-fluorohydrocortisone diacetate
  • D1-9a-Fluoro-16a-hydroxyhydrocortisone diacetate
  • Kenacourt
  • Pregna-1,4-diene-3,20-dione, 16,21-bis(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11b,16a)- (9CI)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,16a,17,21-tetrahydroxy-, 16,21-diacetate (6CI, 7CI, 8CI)
  • Tedarol
  • 16α,21-Diacetoxy-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione
  • Aristocort parenteral
  • [(8S,9R,10S,11S,13S,14S,16R,17S)-17-(2-acetyloxyacetyl)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-16-yl] acetate
  • [(8S,9R,10S,11S,13S,14S,16R,17S)-17-(2-acetyloxyethanoyl)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-16-yl] ethanoate
  • acetic acid [(8S,9R,10S,11S,13S,14S,16R,17S)-17-(2-acetoxyacetyl)-9-fluoro-11,17-dihydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-16-yl] ester
  • Triamcinolone Diacetate (350 mg)
  • triamcinolone 16-alpha,21-di(acetate)
  • (11β,16α)-16,21-Bis(acetyloxy)-9-fluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione
  • 9α-Fluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,21-diacetate
  • 9α-Fluoro-16α-hydroxyprednisolone 16,21-diacetate
  • 16,21-Diacetate