Triamcinolone diacetate

Product Name: Triamcinolone diacetate
CAS No.: 67-78-7
Chemical Name: Triamcinolone diacetate
Synonyms: TAC-D;8357RP;CINO-40;Tedarol;Cenacort;Tracilon;Kenacourt;21-diacetate;Triamolone 40;aristocortsyrup
CBNumber: CB6488260
Molecular Formula: C25H31FO8
Formula Weight: 478.51
MOL File: 67-78-7.mol

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Triamcinolone diacetate Property

Melting point:: 186-188 C
alpha: D25 +22° (chloroform)
Boiling point:: 608.5±55.0 °C(Predicted)
Density: 1.2087 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
pka: 11.21±0.70(Predicted)
form: Solid
color: White
Water Solubility: 48mg/L(25 ºC)
CAS DataBase Reference: 67-78-7(CAS DataBase Reference)
NIST Chemistry Reference: Triamcinolone diacetate(67-78-7)
EPA Substance Registry System: Triamcinolone diacetate (67-78-7)

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Safety

WGK Germany: 3
HS Code: 2937220000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1678005
Product name: Triamcinolone diacetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 350mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: T3676
Product name: Triamcinolone Diacetate
Packaging: 50MG
Price: $74
Updated: 2024/03/01

TCI Chemical

Product number: T3676
Product name: Triamcinolone Diacetate
Packaging: 250MG
Price: $219
Updated: 2024/03/01

TRC

Product number: T767170
Product name: Triamcinolone16,21-Diacetate
Packaging: 25mg
Price: $160
Updated: 2021/12/16

TRC

Product number: T767170
Product name: Triamcinolone16,21-Diacetate
Packaging: 250mg
Price: $1295
Updated: 2021/12/16

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Triamcinolone diacetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Aristocort,Lederle,US,1959

Uses

A glucocorticoid that inhibits prolyl hydroxylase activity and used as an antiasthmatic and antiallergic drug.

Uses

antiinflammatory

Uses

A glucocorticoid that inhibits prolyl hydroxylase activity, Triamcinolone diacetate can be used as an antiasthmatic and antiallergic drug.

Definition

ChEBI: Triamcinolone diacetate is a corticosteroid hormone.

Manufacturing Process

To a solution of 16α,21-diacetoxy-11β,17α-dihydroxy-9α-fluoro-4-pregnene- 3,20-dione (1.0 g) in tertiary-butanol (160 ml) and glacial acetic acid (1.6 ml) was added 600 mg of selenium dioxide, the mixture swept with nitrogen and kept at 70°C for 24 hours, selenium dioxide (350 mg) added, and the mixture swept with nitrogen and allowed to stand for another 24 hours. The reaction mixture was filtered, and the filtrate was evaporated to dryness under reduced pressure. The material so obtained was dissolved in ethyl acetate, washed with saturated sodium bicarbonate, water, cold freshly prepared ammonium sulfide solution, cold dilute ammonia water, cold dilute hydrochloric acid, and finally with water. After treatment with anhydrous sodium sulfate and activated charcoal, filtration through diatomaceous earth and evaporation to dryness under reduced pressure, 850 mg of a tan glass was obtained. Paper strip chromatographic analysis showed predominantly product plus a small amount of starting material. The 850 mg was chromatographed on 320 g of diatomaceous earth containing 160 ml of stationary phase of a solvent system composed of 3,4,3,2-ethyl acetate-petroleum ether (boiling point 90°C to 100°C), methanol, and water, respectively. The column dimensions were 3.8 cm x 78 cm with 460 ml hold back volume. The fifth and sixth hold back volumes were combined and evaporated under reduced pressure to 250 mg of product which, after a single crystallization from acetone petroleum ether, gave 173 mg, melting point 150°C to 190°C. Paper strip chromatography showed a single spot having the same polarity as an authentic sample of 16α,21-diacetoxy-11β,17α-dihydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione. A further crystallization from the same solvent pair gave 134 mg, melting point 185°C to 189°C, bubbles to 230°C.

Therapeutic Function

Glucocorticoid

Safety Profile

An experimental teratogen. Whenheated to decomposition it emits toxic fumes of F^-.

Triamcinolone diacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Triamcinolone diacetate Suppliers

Canada 2 China 95 Europe 1 Germany 2 India 4 Italy 2 Japan 1 Portugal 1 South Korea 1 United Kingdom 6 United States 21 Global 136

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Wuhan DKY Technology Co.,Ltd.

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View Lastest Price from Triamcinolone diacetate manufacturers

Hebei shuoxi biotechnology co. LTD

Product: Triamcinolone diacetate 67-78-7
Price: US $50.00/KG
Min. Order: 10g
Purity: 99.8%
Supply Ability: 10tons
Release date: 2019-11-06

Career Henan Chemical Co

Product: Triamcinolone diacetate 67-78-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

67-78-7, Triamcinolone diacetateRelated Search:

Isopropyl acetate 1-Methoxy-2-propyl acetate Ethylene glycol monoethyl ether acetate 2-Butoxyethyl acetate Triamcinolone Pancuronium bromide 9E,12Z-Tetradecadien-1-yl-acetate Isoflupredone 4-ACETOXY-2-BUTANONE TECH. 90 TRANS-2-FLUOROCYCLOHEXANOL CIS-1,2-CYCLOPENTANEDIOL Descinolone 3-METHYL-1,2-CYCLOPENTANEDIOL FLUOROCYCLOHEXANE (1-FLUOROCYCLOHEXYL)METHANOL FEMA 2348 Fluorine Z,E-9,12-TETRADECADIEN-1-OL

(11beta,16alpha)-16,21-Bis(acetyloxy)-9-fluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione

16-(Acetyloxy)-9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate

21-diacetate

9-alpha-Fluoro-16-alpha-hydroxyprednisolone diacetate

9-alpha-fluoro-16-alpha-hydroxyprednisolonediacetate

9-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,21-diacetate

9-fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione16,21

Aristocort diacetate

Aristocort forte parenteral

Aristocort syrup

aristocortdiacetate

Triamcinolone Impurity 7

aristocortforteparenteral

aristocortsyrup

Cenacort

CINO-40

Kenacort diacetate syrup

kenacortdiacetatesyrup

Pregna-1,4-diene-2,20-dione, 9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, 16,21-diacetate

pregna-1,4-diene-2,20-dione,9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-,16,

Pregna-1,4-diene-3,20-dione, 16,21-bis(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11beta,16alpha)-

TAC-D

Tracilon

Triamcinolone 16,21-diacetate

Triamolone 40

TRIAMCINOLONE DIACETATE

TRIAMCINOLONE ACETATE

1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,21-DIACETATE

16a,21-diacetoxy-9a-fluoro-11b,17a-dihydroxy-1,4-pregnadiene-3,20-dione

9-ALPHA-FLUORO-16-ALPHA-HYDROXYPREDNISOLONE 16,21-DIACETATE

9-ALPHA-FLUORO-11-BETA,16-ALPHA,17-ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,21-DIACETATE

9a-fluoro-16a-hydroxyprednisolone 16,21-diacetate

TRIAMCINOLONEDIACETATE,MICRONIZED,USP

16a-Hydroxy-9a-fluoroprednisolone diacetate

8357RP

9a-Fluoro-1,4-pregnadiene-11b,16a,17a,21-tetraol-3,20-dione 16,21-diacetate

9-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,21-diacetate

Aristocort diacetate forte

Aristocort diacetate parenteral

Aristocort Forte

Aristocort Parenterals

D1-16a-Hydroxy-9a-fluorohydrocortisone diacetate

D1-9a-Fluoro-16a-hydroxyhydrocortisone diacetate

Kenacourt

Pregna-1,4-diene-3,20-dione, 16,21-bis(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11b,16a)- (9CI)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,16a,17,21-tetrahydroxy-, 16,21-diacetate (6CI, 7CI, 8CI)

Tedarol

16α,21-Diacetoxy-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione

Aristocort parenteral

[(8S,9R,10S,11S,13S,14S,16R,17S)-17-(2-acetyloxyacetyl)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-16-yl] acetate

[(8S,9R,10S,11S,13S,14S,16R,17S)-17-(2-acetyloxyethanoyl)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-16-yl] ethanoate

acetic acid [(8S,9R,10S,11S,13S,14S,16R,17S)-17-(2-acetoxyacetyl)-9-fluoro-11,17-dihydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-16-yl] ester

Triamcinolone Diacetate (350 mg)

triamcinolone 16-alpha,21-di(acetate)

(11β,16α)-16,21-Bis(acetyloxy)-9-fluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione

9α-Fluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,21-diacetate

9α-Fluoro-16α-hydroxyprednisolone 16,21-diacetate

16,21-Diacetate