ChemicalBook > CAS DataBase List > 4,7-Dichloroquinoline

4,7-Dichloroquinoline

Product Name
4,7-Dichloroquinoline
CAS No.
86-98-6
Chemical Name
4,7-Dichloroquinoline
Synonyms
COPPER SEBACATE;Sulfate Impurity;4,7-dichloro-quinolin;tl1473;TL 1473;4, 7-dichloroquine;7-Dichloroquinoline;Chloroquine USP RC A;Amodiaquine Impurity;Amobiquine Impurity 1
CBNumber
CB6490818
Molecular Formula
C9H5Cl2N
Formula Weight
198.05
MOL File
86-98-6.mol
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4,7-Dichloroquinoline Property

Melting point:
81-83 °C (lit.)
Boiling point:
298.4 °F (148°C)
Density 
1.4178 (rough estimate)
vapor pressure 
0.103Pa at 25℃
refractive index 
1.6300 (estimate)
Flash point:
164 °C
storage temp. 
2-30°C
solubility 
chloroform: soluble50mg/mL, clear, colorless to greenish-yellow
pka
1.99±0.27(Predicted)
form 
Powder
color 
White to pale brown
PH
3.86 (24.9°C)
biological source
synthetic
Water Solubility 
insoluble
BRN 
125359
InChIKey
HXEWMTXDBOQQKO-UHFFFAOYSA-N
LogP
3.193 at 25℃
CAS DataBase Reference
86-98-6(CAS DataBase Reference)
NIST Chemistry Reference
Quinoline, 4,7-dichloro-(86-98-6)
EPA Substance Registry System
4,7-Dichloroquinoline (86-98-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-22
WGK Germany 
3
RTECS 
VB4200000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29334910
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2438
Product name
Chloroquine Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$668
Updated
2024/03/01
Sigma-Aldrich
Product number
141437
Product name
4,7-Dichloroquinoline
Purity
≥99%
Packaging
25g
Price
$117
Updated
2024/03/01
Sigma-Aldrich
Product number
1118328
Product name
Chloroquine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15MG
Price
$1210
Updated
2024/03/01
Sigma-Aldrich
Product number
1118328
Product name
Chloroquine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1220
Updated
2022/05/15
TCI Chemical
Product number
D1100
Product name
4,7-Dichloroquinoline
Purity
>98.0%(GC)
Packaging
25g
Price
$42
Updated
2024/03/01
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4,7-Dichloroquinoline Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4,7-Dichloroquinoline is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti -microbial agents showing efficacy against common bacterial strains. Chloroquinoline impurity.

Uses

4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It was used in the synthesis of piperaquine. and as starting reagent in the synthesis of {3-amino-5-[(7-chloro-4-quinolyl)amino]phenyl}methanol.

General Description

Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Flammability and Explosibility

Not classified

Synthesis

4,7-Dichloroquinoline is obtained by chlorination of 7-chloro-4-hydroxyquinoline.

Purification Methods

Crystallise the dichloroquinoline from MeOH or 95% EtOH. [Beilstein 20/7 V 316.]

4,7-Dichloroquinoline Preparation Products And Raw materials

Raw materials

7-Chloroquinolin-4-ol

Preparation Products

7-Chloro-4-piperazinoquinoline 4-BROMO-7-CHLOROQUINOLINE CHLOROQUINE
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View Lastest Price from 4,7-Dichloroquinoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4,7-Dichloroquinoline 86-98-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99% GC
Supply Ability
500kgs
Release date
2023-05-15
Jinan Finer Chemical Co., Ltd
Product
4,7-Dichloroquinoline 86-98-6
Price
US $0.00/Kg/Drum
Min. Order
1g
Purity
99%
Supply Ability
20mt
Release date
2020-03-31
Hebei Chuanghai Biotechnology Co., Ltd
Product
4,7-Dichloroquinoline 86-98-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-20

86-98-6, 4,7-DichloroquinolineRelated Search:

1,2-Dichloro-4-(chloromethyl)benzene 2,4-Dichlorophenol CHLOROQUINE Isoquinoline 3，7-Dichloroquinoline acid-8,3,7-DICHLOROQUINOLINE-8-CARBOXYLIC ACID 2',4'-Dichloroacetophenone 2,4-Dichlorobenzoic acid 7,10-dichloro-2-methoxybenzo[b]-1,5-naphthyridine 4,7-DICHLORO-2,8-DIMETHYLQUINOLINE 2-METHYL-4,5,7-TRICHLOROQUINOLINE 4,7-DICHLORO-2-METHYLQUINOLINE 2-METHYL-4,7,8-TRICHLOROQUINOLINE 6,9-Dichloro-2-methoxyacridine 6,7-Dichloroquinoline 2,8-DICHLOROQUINOLINE 5,7-Dichloroquinoline Pigment Red 202 4,8-DICHLOROQUINOLINE

  • Hydroxychloroquine Sulfate Impurity 7（Hydroxychloroquine Sulfate EP Impurity G）
  • Hydroxychloroquine Sulfate EP Impurity G
  • Sulfate Impurity
  • 4,7-DICHLOROQUINOLINE
  • 4,7-dichloro-quinolin
  • TL 1473
  • tl1473
  • Amobiquine Impurity 1
  • COPPER SEBACATE
  • 4,7-Dichloroquinoline,97%
  • 4,7-DICHLOLROQUINOLINE
  • 4,7-DICHLOROQUINOLINE CHLOROQUINE PHOSPHATE
  • 7-Dichloroquinoline
  • Chloroquine Related Compound A (25 mg) (4,7-dichloroquinoline)
  • 4,7-Dichloroquinoline,98%
  • 4,7-Dichloroquinoline,95%,tech.
  • Quinoline, 4,7-dichloro-
  • 4,7-Dichloro-1-azanaphthalene
  • Chloroquine Related CoMpound A
  • 4,7-DICHLOROQUINOLINE, 99+%
  • 4,7-Dichloroquinoline(For Quinoline)
  • Hydroxychloroquine sulfate Impurity 4
  • Amodiaquine Impurity 1 (Hydroxychloroquine Sulfate EP Impurity G)
  • 4,7-Dichloroquinoline&gt
  • Chloroquine USP RC A
  • N4-(7-chloroquinolin-4-yl)-N1-ethylpentane-1,4-diamine sulfate
  • Amodiaquine Dichloro Impurity (Hydroxychloroquine EP Impurity G/ Chloroquine?Related Compound A)
  • 4,7-DICHLOROQUINOLINE 86-98-6
  • Chloroquine?Related Compound A (Amodiaquine Dichloro Impurity/ Hydroxychloroquine EP Impurity G)
  • Hydroxychloroquine EP Impurity G (Amodiaquine Dichloro Impurity)
  • High quailty 4,7-Dichloroquinoline 86-98-6
  • 4,7- DichloroquinolineQ: What is 4,7- Dichloroquinoline Q: What is the CAS Number of 4,7- Dichloroquinoline Q: What is the storage condition of 4,7- Dichloroquinoline
  • Chloroquine Related Compound A (4,7-dichloroquinoline) (1118328)
  • 4, 7-dichloroquine
  • Chloroquine USP Related Compound A
  • Lead hydroxide oxide sulfate 11083-39-9
  • 4,7-dichloroquinoline (4,7-DCQ)
  • 4,7-Dichloroquinolone
  • Hydroxychloroquine Sulfate Impurity G
  • 2,2'-((4-((7-chloroquinolin-4-yl)amino)pentyl)azanediyl)diethanol
  • Hydroxychloroquine EP Impurity G 4,7-Dichlrorquinoline
  • Amodiaquine Impurity
  • 86-98-6
  • 7640-85-7
  • C9H5Cl2N
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Haloquinolines
  • Quinolines
  • Building Blocks
  • Building Blocks
  • C8 to C10
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Haloquinolines
  • Building Blocks
  • Halogenated Heterocycles