ChemicalBook > CAS DataBase List > Z-ASP(OME)-OH

Z-ASP(OME)-OH

Product Name: Z-ASP(OME)-OH
CAS No.: 3160-47-2
Chemical Name: Z-ASP(OME)-OH
Synonyms: Z-ASP(OME)-OH;Z-L-Asp(OMe)-OH;CBZ-ASP(OME)-OH;Z-ASP(OME)-OH,98%;Cbz-L-Asp(OMe)-OH;Z-Asp(OMe)-OH, 98.0%;Z-ASPARTIC ACID(OME)-OH;Z-L-ASPARTIC ACID B-METHYLESTER;Z-L-ASPARTIC ACID 4-METHYL ESTER;Z-L-Aspartic acid β-Methyl ester
CBNumber: CB6493657
Molecular Formula: C13H15NO6
Formula Weight: 281.26
MOL File: 3160-47-2.mol

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Z-ASP(OME)-OH Property

Melting point:: 98 °C
Boiling point:: 503.6±50.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.63±0.23(Predicted)
color: White
BRN: 6279422
InChIKey: PHMBNDDHIBIDRQ-JTQLQIEISA-N
CAS DataBase Reference: 3160-47-2(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 96002
Product name: Z-Asp(OMe)-OH
Purity: ≥98.0% (TLC)
Packaging: 5g
Price: $330
Updated: 2023/01/07

TRC

Product number: A788665
Product name: Z-Asp(OMe)-OH
Packaging: 250mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: E716
Product name: Z-Asp(OMe)-OH
Packaging: 1g
Price: $26
Updated: 2021/12/16

Chem-Impex

Product number: 06406
Product name: Z-L-asparticacidβ-methylester,98%
Purity: 98%
Packaging: 1G
Price: $34.83
Updated: 2021/12/16

Activate Scientific

Product number: AS102822
Product name: Cbz-L-aspartic acid 4-methyl ester
Purity: 95% ee
Packaging: 1g
Price: $35
Updated: 2021/12/16

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Z-ASP(OME)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2177-62-0

501-53-1

3160-47-2

30.5 g (207 mmol) (S)-2-Amino-4-methoxy-4-oxobutanoic acid was dissolved in 726 mL of distilled water and 260 mL of ether was added. Subsequently, 40.15 g (290 mmol) of potassium carbonate was added and stirred until completely dissolved, then 41.5 mL (290 mmol) of benzyl chloroformate was slowly added. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, phase separation was carried out and the organic layer was discarded. The aqueous layer was washed several times with ether and the pH was subsequently adjusted with 1 N hydrochloric acid to 1. The aqueous layer was again extracted several times with ether, the organic layers were combined and dried over magnesium sulfate. Finally, 55 g of (2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid was obtained by vacuum concentration in 94% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.23 (s, 1H), 7.35 (m, 5H), 5.87 (d, 1H), 5.12 (s, 2H), 4.69 (m, 1H), 3.68 (s, 3H), 2.97 (dd, 2H).

References

[1] European Journal of Organic Chemistry, 2003, # 17, p. 3387 - 3397
[2] Patent: WO2012/148246, 2012, A2. Location in patent: Page/Page column 16
[3] Tetrahedron Letters, 2003, vol. 44, # 28, p. 5251 - 5253
[4] Journal of Organic Chemistry, 2009, vol. 74, # 11, p. 4177 - 4187
[5] Tetrahedron Asymmetry, 2011, vol. 22, # 20-22, p. 1849 - 1854

Z-ASP(OME)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Z-ASP(OME)-OH manufacturers

Career Henan Chemical Co

Product: (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid 3160-47-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-22

3160-47-2, Z-ASP(OME)-OHRelated Search:

N-Cbz-L-Aspartic acid 4-benzyl ester Z-ASP(OTBU)-OH DCHA N-Cbz-L-Aspartic acid 4-tert-butyl ester Z-ASP-OME N-Carbobenzyloxy-L-aspartic acid Z-Asp(OtBu)-Glu(OtBu)-OH Z-Asp(OtBu)-His(Trt)-OH Z-DEVD-CMK Z-Asp(OtBu)-OH·H2O Z-ASP(OTBU)-BROMOMETHYLKETONE Z-ASP-OBZL Z-ASP(OSU)-OBZL Z-Asp(OMe)-OtBu Z-ASP(OTBU)-OME Z-ASP(OTBU)-ONP Z-ASP(OTBU)-OSU Z-ASP(ONP)-OBZL Z-ASP(OBZL)-OSU

Z-Asp(OMe)-OH, 98.0%

(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid

N-ALPHA-CARBOBENZOXY-L-ASPARATIC ACID BETA-METHYL ESTER

N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 4-METHYL ESTER

N-CBZ-L-ASPARTIC ACID BETA-METHYL ESTER

(S)-2-BENZYLOXYCARBONYLAMINO-SUCCINIC ACID 4-METHYL ESTER

(S)-2-N-CBZ-AMINO-SUCCINIC ACID 4-METHYL ESTER

Z-ASP(OME)-OH

Z-ASPARTIC ACID(OME)-OH

Z-L-ASPARTIC ACID 4-METHYL ESTER

Z-L-ASPARTIC ACID BETA-METHYL ESTER

N-cbz-L-aspartic acid B-methyl ester

CBZ-L-ASPARTIC ACID BETA METHYL ESTER

Z-L-ASPARTIC ACID B-METHYLESTER

N-carbobenzyloxy-L-aspartic acid beta-methyl ester

N-Cbz-L-aspartic acid β-methyl ester, Z-L-Aspartic acid 4-methyl ester

2-(benzyloxycarbonylamino)-4-keto-4-methoxy-butyric acid

4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid

L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-, 4-methyl ester

Aspartic acid, N-[(phenylMethoxy)carbonyl]-, 4-Methyl ester

(S)-2-(((Benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid

Z-ASP(OME)-OH,98%

Cbz-L-Asp(OMe)-OH

Z-L-Asp(OMe)-OH

CBZ-L-ASPARTIC ACID 4-METHYL ESTER

CBZ-ASP(OME)-OH

N-Cbz-L-aspartic acid 4-methyl ester

4-Methyl hydrogen N-[(phenylmethoxy)carbonyl]-L-aspartate

Z-L-Aspartic acid β-Methyl ester

(2S)-4-Methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid

4-Methyl hydrogen N-CBZ-L-aspartate

3160-47-2

CH3O2CCH2CHNHCO2CH2C6H5CO2H

Amino Acid Derivatives

Aspartic Acid

Peptide Synthesis

Specialty Synthesis

Z-Amino Acids and Derivatives

Z-Amino acid series