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Z-ASP(OME)-OH

Product Name
Z-ASP(OME)-OH
CAS No.
3160-47-2
Chemical Name
Z-ASP(OME)-OH
Synonyms
Z-ASP(OME)-OH;Z-L-Asp(OMe)-OH;CBZ-ASP(OME)-OH;Z-ASP(OME)-OH,98%;Cbz-L-Asp(OMe)-OH;Z-Asp(OMe)-OH, 98.0%;Z-ASPARTIC ACID(OME)-OH;Z-L-ASPARTIC ACID B-METHYLESTER;Z-L-ASPARTIC ACID 4-METHYL ESTER;Z-L-Aspartic acid β-Methyl ester
CBNumber
CB6493657
Molecular Formula
C13H15NO6
Formula Weight
281.26
MOL File
3160-47-2.mol
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Z-ASP(OME)-OH Property

Melting point:
98 °C
Boiling point:
503.6±50.0 °C(Predicted)
Density 
1.304±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
3.63±0.23(Predicted)
color 
White
BRN 
6279422
InChIKey
PHMBNDDHIBIDRQ-JTQLQIEISA-N
CAS DataBase Reference
3160-47-2(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
96002
Product name
Z-Asp(OMe)-OH
Purity
≥98.0% (TLC)
Packaging
5g
Price
$330
Updated
2023/01/07
TRC
Product number
A788665
Product name
Z-Asp(OMe)-OH
Packaging
250mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
E716
Product name
Z-Asp(OMe)-OH
Packaging
1g
Price
$26
Updated
2021/12/16
Chem-Impex
Product number
06406
Product name
Z-L-asparticacidβ-methylester,98%
Purity
98%
Packaging
1G
Price
$34.83
Updated
2021/12/16
Activate Scientific
Product number
AS102822
Product name
Cbz-L-aspartic acid 4-methyl ester
Purity
95% ee
Packaging
1g
Price
$35
Updated
2021/12/16
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Z-ASP(OME)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2177-62-0

501-53-1

3160-47-2

30.5 g (207 mmol) (S)-2-Amino-4-methoxy-4-oxobutanoic acid was dissolved in 726 mL of distilled water and 260 mL of ether was added. Subsequently, 40.15 g (290 mmol) of potassium carbonate was added and stirred until completely dissolved, then 41.5 mL (290 mmol) of benzyl chloroformate was slowly added. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, phase separation was carried out and the organic layer was discarded. The aqueous layer was washed several times with ether and the pH was subsequently adjusted with 1 N hydrochloric acid to 1. The aqueous layer was again extracted several times with ether, the organic layers were combined and dried over magnesium sulfate. Finally, 55 g of (2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid was obtained by vacuum concentration in 94% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.23 (s, 1H), 7.35 (m, 5H), 5.87 (d, 1H), 5.12 (s, 2H), 4.69 (m, 1H), 3.68 (s, 3H), 2.97 (dd, 2H).

References

[1] European Journal of Organic Chemistry, 2003, # 17, p. 3387 - 3397
[2] Patent: WO2012/148246, 2012, A2. Location in patent: Page/Page column 16
[3] Tetrahedron Letters, 2003, vol. 44, # 28, p. 5251 - 5253
[4] Journal of Organic Chemistry, 2009, vol. 74, # 11, p. 4177 - 4187
[5] Tetrahedron Asymmetry, 2011, vol. 22, # 20-22, p. 1849 - 1854

Z-ASP(OME)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-ASP(OME)-OH Suppliers

China 138 Germany 4 India 1 Japan 2 South Korea 1 Switzerland 2 United Kingdom 7 United States 21 Global 176
chemcube
Tel
--
Fax
--
Email
sales@chemcube.eu
Country
Germany
ProdList
4083
Advantage
34
PARAGOS
Tel
--
Fax
--
Email
info@paragos.com
Country
Germany
ProdList
6371
Advantage
39
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from Z-ASP(OME)-OH manufacturers

Career Henan Chemical Co
Product
(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid 3160-47-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-22

3160-47-2, Z-ASP(OME)-OHRelated Search:

N-Cbz-L-Aspartic acid 4-benzyl ester Z-ASP(OTBU)-OH DCHA N-Cbz-L-Aspartic acid 4-tert-butyl ester Z-ASP-OME N-Carbobenzyloxy-L-aspartic acid Z-Asp(OtBu)-Glu(OtBu)-OH Z-Asp(OtBu)-His(Trt)-OH Z-DEVD-CMK Z-Asp(OtBu)-OH·H2O Z-ASP(OTBU)-BROMOMETHYLKETONE Z-ASP-OBZL Z-ASP(OSU)-OBZL Z-Asp(OMe)-OtBu Z-ASP(OTBU)-OME Z-ASP(OTBU)-ONP Z-ASP(OTBU)-OSU Z-ASP(ONP)-OBZL Z-ASP(OBZL)-OSU

  • Z-Asp(OMe)-OH, 98.0%
  • (2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid
  • N-ALPHA-CARBOBENZOXY-L-ASPARATIC ACID BETA-METHYL ESTER
  • N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 4-METHYL ESTER
  • N-CBZ-L-ASPARTIC ACID BETA-METHYL ESTER
  • (S)-2-BENZYLOXYCARBONYLAMINO-SUCCINIC ACID 4-METHYL ESTER
  • (S)-2-N-CBZ-AMINO-SUCCINIC ACID 4-METHYL ESTER
  • Z-ASP(OME)-OH
  • Z-ASPARTIC ACID(OME)-OH
  • Z-L-ASPARTIC ACID 4-METHYL ESTER
  • Z-L-ASPARTIC ACID BETA-METHYL ESTER
  • N-cbz-L-aspartic acid B-methyl ester
  • CBZ-L-ASPARTIC ACID BETA METHYL ESTER
  • Z-L-ASPARTIC ACID B-METHYLESTER
  • N-carbobenzyloxy-L-aspartic acid beta-methyl ester
  • N-Cbz-L-aspartic acid β-methyl ester, Z-L-Aspartic acid 4-methyl ester
  • 2-(benzyloxycarbonylamino)-4-keto-4-methoxy-butyric acid
  • 4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid
  • L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-, 4-methyl ester
  • Aspartic acid, N-[(phenylMethoxy)carbonyl]-, 4-Methyl ester
  • (S)-2-(((Benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid
  • Z-ASP(OME)-OH,98%
  • Cbz-L-Asp(OMe)-OH
  • Z-L-Asp(OMe)-OH
  • CBZ-L-ASPARTIC ACID 4-METHYL ESTER
  • CBZ-ASP(OME)-OH
  • N-Cbz-L-aspartic acid 4-methyl ester
  • 4-Methyl hydrogen N-[(phenylmethoxy)carbonyl]-L-aspartate
  • Z-L-Aspartic acid β-Methyl ester
  • (2S)-4-Methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid
  • 4-Methyl hydrogen N-CBZ-L-aspartate
  • 3160-47-2
  • CH3O2CCH2CHNHCO2CH2C6H5CO2H
  • Amino Acid Derivatives
  • Aspartic Acid
  • Peptide Synthesis
  • Specialty Synthesis
  • Z-Amino Acids and Derivatives
  • Z-Amino acid series