Cyclizine Hydrochloride
- Product Name
- Cyclizine Hydrochloride
- CAS No.
- 303-25-3
- Chemical Name
- Cyclizine Hydrochloride
- Synonyms
- Collox;Echnatol;Fortravel;CYCLYZINE HCL;Einecs 206-136-9;cyclizinechloride;marezinehydrochloride;CYCLIZINE HYDROCHLORIDE;Cyclizini hydrochloridum;Cyclizine hydrochloride CRS
- CBNumber
- CB6500522
- Molecular Formula
- C18H23ClN2
- Formula Weight
- 302.84162
- MOL File
- 303-25-3.mol
Cyclizine Hydrochloride Property
- Melting point:
- 258-260℃
- Boiling point:
- 457.04°C (rough estimate)
- Density
- 1.0551 (rough estimate)
- refractive index
- 1.5749 (estimate)
- storage temp.
- Refrigerator
- solubility
- Methanol: 1 mg/ml
Safety
- Hazard Codes
- T
- Risk Statements
- 61-23/24/25-42/43
- Safety Statements
- 53-22-36/37/39-45
- RIDADR
- 3249
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2933595960
- Toxicity
- mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C3090000
- Product name
- Cyclizine hydrochloride
- Purity
- (European Pharmacopoeia (EP) Reference Standard)
- Packaging
- c3090000
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 1154004
- Product name
- Cyclizine hydrochloride
- Packaging
- 200mg
- Price
- $453
- Updated
- 2024/03/01
- Product number
- C-231
- Product name
- Cyclizine HCl solution
- Purity
- 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant?
- Packaging
- 1ML
- Price
- $106
- Updated
- 2022/05/15
- Product number
- C3090000
- Product name
- Cyclizine hydrochloride
- Purity
- (European Pharmacopoeia (EP) Reference Standard)
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FC20679
- Product name
- Cyclizine hydrochloride
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
Cyclizine Hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
moderately soluble in water
Originator
Marezine,BurroughsWellcome,US,1953
Uses
Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
Uses
Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli
Definition
ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.
Manufacturing Process
One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.
Therapeutic Function
Antinauseant
Cyclizine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclizine Hydrochloride Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from Cyclizine Hydrochloride manufacturers
- Product
- Cyclizine Hydrochloride 303-25-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2019-12-27
- Product
- Cyclizine Hydrochloride 303-25-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- Cyclizine Hydrochloride 303-25-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09