Cyclizine
- Product Name
- Cyclizine
- CAS No.
- 82-92-8
- Chemical Name
- Cyclizine
- Synonyms
- Valoid;Emoquil;bw47-83;Marzine;Bw 47-83;Marazine;Marezine;Wellcome;Ciclizina;Nautazine
- CBNumber
- CB5336795
- Molecular Formula
- C18H22N2
- Formula Weight
- 266.38
- MOL File
- 82-92-8.mol
Cyclizine Property
- Melting point:
- 105.5-107.5°
- Boiling point:
- 399.58°C (rough estimate)
- Density
- 0.9934 (rough estimate)
- refractive index
- 1.5840 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Slightly soluble in water and in ethanol (96 per cent).
Safety
- Hazardous Substances Data
- 82-92-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S361267
- Product name
- 1-(DIPHENYLMETHYL)-4-METHYLPIPERAZINE
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $179
- Updated
- 2024/03/01
- Product number
- FC31349
- Product name
- Cyclizine Base
- Packaging
- 100g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 058068
- Product name
- 1-Benzhydryl-4-methylpiperazine
- Purity
- 95%
- Packaging
- 25g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FC31349
- Product name
- Cyclizine Base
- Packaging
- 50g
- Price
- $87.5
- Updated
- 2021/12/16
- Product number
- FC31349
- Product name
- Cyclizine Base
- Packaging
- 250g
- Price
- $275
- Updated
- 2021/12/16
Cyclizine Chemical Properties,Usage,Production
Chemical Properties
White or almost white, crystalline powder.
Originator
Marezine,BurroughsWellcome,US,1953
Uses
Cyclizine exhibits antihistamine and anticholinergic action and is used for vomiting and diarrhea. The exact mechanism of action is not known. Synonyms of this drug are marezine and migril.
Uses
Cyclizine is an antihistamine with a sedative effect used in the treatment of nausea and vomiting associated with motion sickness.
Uses
H1 antihistamine
Definition
ChEBI: An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group.
Preparation
Cyclizine is prepared through the alkylation of N-methylpiperazine with benzhydryl chloride.
Manufacturing Process
One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.
brand name
Marezine (GlaxoSmithKline).
Therapeutic Function
Antinauseant
General Description
Cyclizine hydrochloride,1-(diphenylmethyl)-4-methylpiperazine monohydrochloride(Marezine), occurs as a light-sensitive, white crystallinepowder with a bitter taste. It is slightly soluble in water(1:115), in alcohol (1:115), and in chloroform (1:75). It isused primarily in the prophylaxis and treatment of motionsickness. The lactate salt (Cyclizine Lactate Injection,United States Pharmacopoeia [USP]) is used for intramuscular(IM) injection because of the limited water solubilityof the hydrochloride. The injection should be stored in acold place, because if it is stored at room temperature forseveral months, a slight yellow tint may develop. This doesnot indicate a loss in biologic potency.
Clinical Use
It can be used not only in the treatment of allergic diseases, but also in the management of postoperative, irradiation or druginduced vomiting. Cyclizine dependence has been suggested to occur when it is used in combination with analgesics in long-term therapy. For this reason, several countries have removed cyclicine from analgesic combination preparations.
Synthesis
Cyclizine, 1-(diphenylmethyl)-4-methylpiperazine (16.1.15), is synthesized by alkylating 1-methylpiperazine with benzhydrylbromide.
Cyclizine Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclizine Suppliers
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View Lastest Price from Cyclizine manufacturers
- Product
- CYCLIZINE HCL 82-92-8
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-04-11
- Product
- Cyclizine
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-17