BUCLIZINE

Product Name: BUCLIZINE
CAS No.: 82-95-1
Chemical Name: BUCLIZINE
Synonyms: ah2526;AH 2526;Postafen;Bucladin;Buclifen;Buclozin;BUCLIZINE;Hitabutyzyne;Histabutyzine;Histabutizine
CBNumber: CB9111794
Molecular Formula: C28H33ClN2
Formula Weight: 433.03
MOL File: 82-95-1.mol

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BUCLIZINE Property

Boiling point:: bp0.001 217-220°
Density: 0.9970 (rough estimate)
refractive index: 1.5940 (estimate)
pka: 6.84±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 443556
Product name: Buclizine
Packaging: 2.5mg
Price: $602
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT61369
Product name: Buclizine
Packaging: 10mg
Price: $775
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009055
Product name: BUCLIZINE
Purity: 95.00%
Packaging: 1G
Price: $1358.28
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT61369
Product name: Buclizine
Packaging: 25mg
Price: $1737.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT61369
Product name: Buclizine
Packaging: 50mg
Price: $3250
Updated: 2021/12/16

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BUCLIZINE Chemical Properties,Usage,Production

Originator

Longifine,UCB

Uses

Buclizine is an antinauseant.

Definition

ChEBI: An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.

Manufacturing Process

1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.

brand name

Bucladin (Stuart).

Therapeutic Function

Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant

Synthesis

Buclizine is mainly used in the prevention of motion sickness and in combination with analgesics for treatment of migraine.

BUCLIZINE Preparation Products And Raw materials

Raw materials

Paraformaldehyde tert-Butylbenzene 1-Benzylpiperazine BROMO(4-CHLOROPHENYL)PHENYL METHANE Aluminium chloride hexahydrate

Preparation Products

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BUCLIZINE Suppliers

China 44 Europe 2 Germany 1 India 4 United Kingdom 2 United States 9 Global 62

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Wuhai Shuou Technology Co., Ltd.

Tel: 17792809151
Fax: 18872220797
Email: 2355916837@ycphar.com
Country: China
ProdList: 6133
Advantage: 55

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4983
Advantage: 55

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Wuhan Netcom Electronic Commerce Limited

Tel: 18064670521
Fax: 0757-88210752
Email: 2355935187@ycphar.com
Country: China
ProdList: 4879
Advantage: 58

Conier Chem & Pharma Limited

Tel: 13368167990
Email: sales@conier.com
Country: China
ProdList: 2830
Advantage: 58

82-95-1, BUCLIZINERelated Search:

Cetirizine dihydrochloride Cetirizine 1-BENZHYDRYLPIPERAZINE 1-(4-METHYLBENZYL)PIPERAZINE 1-(4-CHLOROBENZYL)PIPERAZINE 4-tert-Butylbenzylamine 1-(4-Chlorobenzhydryl)piperazine BUCLIZINE CHLORCYCLIZINE Cyclizine BUCLIZINE, DIHYDROCHLORIDE,BUCLIZINE 2HCL 1-(4-TERT-BUTYLBENZYL)PIPERAZINE N-(4-ISOPROPYLBENZYL)ETHANAMINE migraleve 1-(4-ETHYL-BENZYL)-PIPERAZINE BUCLIZINE HCL BUCLIZINE HYDROCHLORIDE IMP. A (BP): 1,4-BIS(4-CHLOROBENZHYDRYL)PIPERAZINE BUCLIZINE HYDROCHLORIDE IMPURITY STANDARD

Histabuticine

Histabutizine

Histabutyzine

Hitabutyzyne

Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-

piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)

Postafen

ah2526

Aphilan-R base

aphilan-rbase

Bucladin

Buclifen

1-[4-(Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperrazine

AH 2526

1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine

1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-piperazin

1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine

Buclozin

Buclizine diHCl

BUCLIZINE

1-(4-tert-butylbenzyl)-4-(4-chlorobenzhydryl)piperazine

Buclizinebase

Buclizine (base and/or unspecified salts)

82-95-1

1129-74-8

C28H33ClN2