BUCLIZINE

ChemicalBook > CAS DataBase List > BUCLIZINE

Product Name: BUCLIZINE
CAS No.: 82-95-1
Chemical Name: BUCLIZINE
Synonyms: ah2526;AH 2526;Postafen;Bucladin;Buclifen;Buclozin;BUCLIZINE;Hitabutyzyne;Histabutyzine;Histabutizine
CBNumber: CB9111794
Molecular Formula: C28H33ClN2
Formula Weight: 433.03
MOL File: 82-95-1.mol

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BUCLIZINE Property

Boiling point:: bp0.001 217-220°
Density: 0.9970 (rough estimate)
refractive index: 1.5940 (estimate)
pka: 6.84±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 443556
Product name: Buclizine
Packaging: 2.5mg
Price: $602
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT61369
Product name: Buclizine
Packaging: 5mg
Price: $495
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT61369
Product name: Buclizine
Packaging: 10mg
Price: $775
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009055
Product name: BUCLIZINE
Purity: 95.00%
Packaging: 1G
Price: $1358.28
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT61369
Product name: Buclizine
Packaging: 25mg
Price: $1737.5
Updated: 2021/12/16

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BUCLIZINE Chemical Properties,Usage,Production

Originator

Longifine,UCB

Uses

Buclizine is an antinauseant.

Definition

ChEBI: An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.

Manufacturing Process

1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.

brand name

Bucladin (Stuart).

Therapeutic Function

Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant

Synthesis

Buclizine is mainly used in the prevention of motion sickness and in combination with analgesics for treatment of migraine.

BUCLIZINE Preparation Products And Raw materials

Raw materials

Paraformaldehyde tert-Butylbenzene 1-Benzylpiperazine BROMO(4-CHLOROPHENYL)PHENYL METHANE Aluminium chloride hexahydrate

Preparation Products

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82-95-1, BUCLIZINERelated Search:

Cetirizine dihydrochloride Cetirizine 1-BENZHYDRYLPIPERAZINE 1-(4-METHYLBENZYL)PIPERAZINE 1-(4-CHLOROBENZYL)PIPERAZINE 4-tert-Butylbenzylamine 1-(4-Chlorobenzhydryl)piperazine BUCLIZINE CHLORCYCLIZINE Cyclizine BUCLIZINE, DIHYDROCHLORIDE,BUCLIZINE 2HCL 1-(4-TERT-BUTYLBENZYL)PIPERAZINE N-(4-ISOPROPYLBENZYL)ETHANAMINE migraleve 1-(4-ETHYL-BENZYL)-PIPERAZINE BUCLIZINE HCL BUCLIZINE HYDROCHLORIDE IMP. A (BP): 1,4-BIS(4-CHLOROBENZHYDRYL)PIPERAZINE BUCLIZINE HYDROCHLORIDE IMPURITY STANDARD

Histabuticine

Histabutizine

Histabutyzine

Hitabutyzyne

Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-

piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)

Postafen

ah2526

Aphilan-R base

aphilan-rbase

Bucladin

Buclifen

1-[4-(Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperrazine

AH 2526

1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine

1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-piperazin

1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine

Buclozin

Buclizine diHCl

BUCLIZINE

1-(4-tert-butylbenzyl)-4-(4-chlorobenzhydryl)piperazine

Buclizinebase

Buclizine (base and/or unspecified salts)

82-95-1

1129-74-8

C28H33ClN2