ChemicalBook > CAS DataBase List > Meclozine

Meclozine

Product Name
Meclozine
CAS No.
569-65-3
Chemical Name
Meclozine
Synonyms
Marex;Bonine;Sabari;Subari;Ancolan;Ancolon;Ravelon;Siguran;UCB 170;UCB 5062
CBNumber
CB2753083
Molecular Formula
C25H27ClN2
Formula Weight
390.95
MOL File
569-65-3.mol
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Meclozine Property

Boiling point:
bp2 230°
Density 
1.0318 (rough estimate)
refractive index 
1.5940 (estimate)
storage temp. 
2-8°C
pka
pKa 2.05(H2O,t =25,I=0.0051(NaCl)) (Uncertain)
BCS Class
2
CAS DataBase Reference
569-65-3(CAS DataBase Reference)
NIST Chemistry Reference
Meclizine(569-65-3)
EPA Substance Registry System
Meclizine (569-65-3)
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Safety

Hazardous Substances Data
569-65-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
Q714
Product name
Meclizine
Packaging
50mg
Price
$170
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015857
Product name
MECLOZINE
Purity
95.00%
Packaging
1G
Price
$852.55
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015857
Product name
MECLOZINE
Purity
95.00%
Packaging
2.5G
Price
$1227.82
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015857
Product name
MECLOZINE
Purity
95.00%
Packaging
5G
Price
$1548.26
Updated
2021/12/16
Chemenu
Product number
CM169566
Product name
1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine
Purity
95%
Packaging
5g
Price
$234
Updated
2021/12/16
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Meclozine Chemical Properties,Usage,Production

Originator

Antivert,Roerig,US,1957

Uses

Anti-emetic.

Uses

Meclizine actively affects the vomiting center and is used for vomiting and diarrhea. Synonyms of this drug are antivert, bonine, lamin, roclizin, and vertol.

Definition

ChEBI: Meclizine is a diarylmethane.

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer);Ancoloxine;Bonamina;Bonamine;Calmonal;Chiclida;Cobinamide;Diadril;Dradril;Duremesan;Itinerol;Mecazine;Navicalm;Neo-istafenc;Neo-istafene;Peremesin;Postafene;Premesin;Rovert-m;Ru-vert-m;Sea-leg;Supermesin;Superminal;Suprimal;Taizerl;V-cline;Veritab;Vertizine;Vomaxine;Vomisseis.

Therapeutic Function

Antinauseant

World Health Organization (WHO)

Meclozine, an antihistamine with antiemetic activity, was introduced in 1953 for the treatment of nausea. The action taken in Indonesia in 1963 resulted from concern regarding its possible teratogenic potential. Subsequent epidemiological studies have been widely accepted, however, as dispelling this suspicion. Meclozine remains widely available in both prescription only and over-the-counter preparations and in some countries the licensed indications include management of nausea of pregnancy.

Synthesis

Meclizine, 1-[(4-chlorphenyl)methyl]-4-[(3-methylphenyl)phenyl]piperazine (16.1.16), is synthesized by reductive amination of a mixture of 3-methylbenzaldehyde with 1-(4-chlorbenzhydryl)piperazine using hydrogen over Raney nickel.

Meclozine Preparation Products And Raw materials

Raw materials

Preparation Products

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Meclozine Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14059
Advantage
65
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17944
Advantage
56
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1910
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3974
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19806
Advantage
60
Huaian Hyperion pharmaceutical R&D Co.,Ltd.
Tel
18114966287
Fax
-
Email
sales@hyperionpharm.com
Country
China
ProdList
313
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4880
Advantage
58
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View Lastest Price from Meclozine manufacturers

Sigma Audley
Product
Meclozine 569-65-3
Price
US $45.00-35.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
200tons/year
Release date
2024-03-19
Shaanxi Dideu Medichem Co. Ltd
Product
Meclozine 569-65-3
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
Dideu Industries Group Limited
Product
Meclozine 569-65-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-16

569-65-3, MeclozineRelated Search:


  • UCB 5052
  • UCB 5062
  • Vomisseis
  • Vomissels
  • 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine
  • mecilizine
  • NSC 169189
  • Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)- (6CI, 8CI)
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]- (9CI)
  • MECLIZINE
  • MECLOZINE
  • 1-[(4-chlorophenyl)-phenyl-methyl]-4-[(3-methylphenyl)methyl]piperazine
  • 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazin 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)piperazine 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine 1-p-chlorobenzhydryl-4-m-methylbenzylpiperazine ancolan antivert
  • 1-(P-CHLORO-ALPHA-PHENYLBENZYL)-4-(M-METHYLBENZYL)-PIPERAZIN
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediami
  • 2-Methyl Meclizine IsoMer
  • 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine
  • 1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine
  • Ancolan
  • Ancolon
  • Bonadettes
  • Bonadoxin
  • Bonine
  • Calmonal
  • Chiclida
  • Histamethine
  • Histamethizine
  • Histametizine
  • Histametizyne
  • Itinerol
  • Marex
  • Monamine
  • Navicalm
  • Neo-Istafene
  • neo-Suprimal
  • neo-Suprimel
  • Parachloramine
  • Peremesin
  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-
  • Postafene
  • Ravelon
  • Sabari
  • Sea-Legs
  • Siguran
  • Subari
  • Suprimal
  • Travelon
  • U. C. B. 5062
  • UCB 170
  • Meclozine USP/EP/BP
  • 1-[(RS)-(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
  • 569-65-3
  • C25H27ClN2