Meclozine

ChemicalBook > CAS DataBase List > Meclozine

Product Name: Meclozine
CAS No.: 569-65-3
Chemical Name: Meclozine
Synonyms: Marex;Bonine;Sabari;Subari;Ancolan;Ancolon;Ravelon;Siguran;UCB 170;UCB 5062
CBNumber: CB2753083
Molecular Formula: C25H27ClN2
Formula Weight: 390.95
MOL File: 569-65-3.mol

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Meclozine Property

Boiling point:: bp2 230°
Density: 1.0318 (rough estimate)
refractive index: 1.5940 (estimate)
storage temp.: 2-8°C
pka: pKa 2.05(H2O,t =25,I=0.0051(NaCl)) (Uncertain)
BCS Class: 2
CAS DataBase Reference: 569-65-3(CAS DataBase Reference)
NIST Chemistry Reference: Meclizine(569-65-3)
EPA Substance Registry System: Meclizine (569-65-3)

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Safety

Hazardous Substances Data: 569-65-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: Q714
Product name: Meclizine
Packaging: 50mg
Price: $170
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015857
Product name: MECLOZINE
Purity: 95.00%
Packaging: 1G
Price: $852.55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015857
Product name: MECLOZINE
Purity: 95.00%
Packaging: 2.5G
Price: $1227.82
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015857
Product name: MECLOZINE
Purity: 95.00%
Packaging: 5G
Price: $1548.26
Updated: 2021/12/16

Chemenu

Product number: CM169566
Product name: 1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine
Purity: 95%
Packaging: 5g
Price: $234
Updated: 2021/12/16

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Meclozine Chemical Properties,Usage,Production

Originator

Antivert,Roerig,US,1957

Uses

Anti-emetic.

Uses

Meclizine actively affects the vomiting center and is used for vomiting and diarrhea. Synonyms of this drug are antivert, bonine, lamin, roclizin, and vertol.

Definition

ChEBI: Meclizine is a diarylmethane.

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer);Ancoloxine;Bonamina;Bonamine;Calmonal;Chiclida;Cobinamide;Diadril;Dradril;Duremesan;Itinerol;Mecazine;Navicalm;Neo-istafenc;Neo-istafene;Peremesin;Postafene;Premesin;Rovert-m;Ru-vert-m;Sea-leg;Supermesin;Superminal;Suprimal;Taizerl;V-cline;Veritab;Vertizine;Vomaxine;Vomisseis.

Therapeutic Function

Antinauseant

World Health Organization (WHO)

Meclozine, an antihistamine with antiemetic activity, was introduced in 1953 for the treatment of nausea. The action taken in Indonesia in 1963 resulted from concern regarding its possible teratogenic potential. Subsequent epidemiological studies have been widely accepted, however, as dispelling this suspicion. Meclozine remains widely available in both prescription only and over-the-counter preparations and in some countries the licensed indications include management of nausea of pregnancy.

Synthesis

Meclizine, 1-[(4-chlorphenyl)methyl]-4-[(3-methylphenyl)phenyl]piperazine (16.1.16), is synthesized by reductive amination of a mixture of 3-methylbenzaldehyde with 1-(4-chlorbenzhydryl)piperazine using hydrogen over Raney nickel.

Meclozine Preparation Products And Raw materials

Raw materials

Diphenyl Benzyl chloride CHLORCYCLIZINE 1-BENZHYDRYLPIPERAZINE 1-Benzylpiperazine Sodium amide

Preparation Products

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View Lastest Price from Meclozine manufacturers

Sigma Audley

Product: Meclozine 569-65-3
Price: US $45.00-35.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-19

Career Henan Chemical Co

Product: Meclozine 569-65-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

569-65-3, MeclozineRelated Search:

Bensulfuron methyl Chlorodimethylphenylsilane 2-Chlorobenzaldehyde 2,4-Dichlorobenzyl chloride Thiophanate-methyl PHENYL VALERATE Methyl acrylate Triphenylmethyl Chloride Methylparaben Kresoxim-methyl Benzyl chloride 1-Methylpiperazine HEXACHLOROBENZENE tert-Butylchlorodiphenylsilane 1,3-Dichlorobenzene Chlorphenamine maleate 2-Methylbenzotrifluoride 4-Chlorotoluene

UCB 5052

UCB 5062

Vomisseis

Vomissels

1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine

mecilizine

NSC 169189

Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)- (6CI, 8CI)

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]- (9CI)

MECLIZINE

MECLOZINE

1-[(4-chlorophenyl)-phenyl-methyl]-4-[(3-methylphenyl)methyl]piperazine

1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazin 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)piperazine 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine 1-p-chlorobenzhydryl-4-m-methylbenzylpiperazine ancolan antivert

1-(P-CHLORO-ALPHA-PHENYLBENZYL)-4-(M-METHYLBENZYL)-PIPERAZIN

1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediami

2-Methyl Meclizine IsoMer

1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine

1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine

1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine

1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine

Ancolan

Ancolon

Bonadettes

Bonadoxin

Bonine

Calmonal

Chiclida

Histamethine

Histamethizine

Histametizine

Histametizyne

Itinerol

Marex

Monamine

Navicalm

Neo-Istafene

neo-Suprimal

neo-Suprimel

Parachloramine

Peremesin

Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-

Postafene

Ravelon

Sabari

Sea-Legs

Siguran

Subari

Suprimal

Travelon

U. C. B. 5062

UCB 170

Meclozine USP/EP/BP

1-[(RS)-(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine

569-65-3

C25H27ClN2