ChemicalBook > CAS DataBase List > Cyclizine Hydrochloride

Cyclizine Hydrochloride

Product Name
Cyclizine Hydrochloride
CAS No.
303-25-3
Chemical Name
Cyclizine Hydrochloride
Synonyms
Collox;Echnatol;Fortravel;CYCLYZINE HCL;Einecs 206-136-9;cyclizinechloride;marezinehydrochloride;CYCLIZINE HYDROCHLORIDE;Cyclizini hydrochloridum;Cyclizine hydrochloride CRS
CBNumber
CB6500522
Molecular Formula
C18H23ClN2
Formula Weight
302.84162
MOL File
303-25-3.mol
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Cyclizine Hydrochloride Property

Melting point:
258-260℃
Boiling point:
457.04°C (rough estimate)
Density 
1.0551 (rough estimate)
refractive index 
1.5749 (estimate)
storage temp. 
Refrigerator
solubility 
Methanol: 1 mg/ml
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Safety

Hazard Codes 
T
Risk Statements 
61-23/24/25-42/43
Safety Statements 
53-22-36/37/39-45
RIDADR 
3249
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933595960
Toxicity
mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C3090000
Product name
Cyclizine hydrochloride
Purity
(European Pharmacopoeia (EP) Reference Standard)
Packaging
c3090000
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
1154004
Product name
Cyclizine hydrochloride
Packaging
200mg
Price
$453
Updated
2024/03/01
Sigma-Aldrich
Product number
C-231
Product name
Cyclizine HCl solution
Purity
1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant?
Packaging
1ML
Price
$106
Updated
2022/05/15
Sigma-Aldrich
Product number
C3090000
Product name
Cyclizine hydrochloride
Purity
(European Pharmacopoeia (EP) Reference Standard)
Price
$190
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20679
Product name
Cyclizine hydrochloride
Packaging
2g
Price
$50
Updated
2021/12/16
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Cyclizine Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid
moderately soluble in water

Originator

Marezine,BurroughsWellcome,US,1953

Uses

Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.

Uses

Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli

Definition

ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.

Manufacturing Process

One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.

Therapeutic Function

Antinauseant

Cyclizine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclizine Hydrochloride Suppliers

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View Lastest Price from Cyclizine Hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Cyclizine Hydrochloride 303-25-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2019-12-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cyclizine Hydrochloride 303-25-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Cyclizine Hydrochloride 303-25-3
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

303-25-3, Cyclizine HydrochlorideRelated Search:

Cyclizine

  • CYCLIZINE HYDROCHLORIDE
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  • CYCLYZINE HCL
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  • Echnatol
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  • Fortravel
  • 1-(diphenylmethyl)-4-methyl-piperazinhydrochloride
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  • Cyclizine HydrochlorideQ: What is Cyclizine Hydrochloride Q: What is the CAS Number of Cyclizine Hydrochloride Q: What is the storage condition of Cyclizine Hydrochloride Q: What are the applications of Cyclizine Hydrochloride
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