N,N-DIBENZYLGLYCINE ETHYL ESTER
- Product Name
- N,N-DIBENZYLGLYCINE ETHYL ESTER
- CAS No.
- 77385-90-1
- Chemical Name
- N,N-DIBENZYLGLYCINE ETHYL ESTER
- Synonyms
- Di-Bzl-Gly-OEt;Ethyl 2-(dibenzylamino);Ethyl N,N-dibenzylglycinate;Ethyl (dibenzylamino)acetate;N,N-Dibenzyl-O-ethylglycinate;N,N-dibenzylglycine ethyl este;N,N-DIBENZYLGLYCINE ETHYL ESTER;N,N-DibenzylglycineEthylEster>DIBENZYLAMINO-ACETIC ACID ETHYL ESTER;N,N-bis(phenylmethyl)Glycineethyl ester
- CBNumber
- CB6500724
- Molecular Formula
- C18H21NO2
- Formula Weight
- 283.36
- MOL File
- 77385-90-1.mol
N,N-DIBENZYLGLYCINE ETHYL ESTER Property
- Melting point:
- 56 °C
- Boiling point:
- 376℃
- Density
- 1.091
- Flash point:
- 123℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 5.47±0.50(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C18H21NO2/c1-2-21-18(20)15-19(13-16-9-5-3-6-10-16)14-17-11-7-4-8-12-17/h3-12H,2,13-15H2,1H3
- InChIKey
- AFMDCFOWHWNQBP-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)CN(CC1=CC=CC=C1)CC1=CC=CC=C1
Safety
- HS Code
- 2922.49.3700
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- R243361
- Product name
- DIBENZYLAMINO-ACETIC ACID ETHYL ESTER
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- D3165
- Product name
- N,N-Dibenzylglycine Ethyl Ester
- Purity
- >98.0%(GC)(N)
- Packaging
- 5g
- Price
- $101
- Updated
- 2025/07/31
- Product number
- D3165
- Product name
- N,N-Dibenzylglycine Ethyl Ester
- Purity
- >98.0%(GC)(N)
- Packaging
- 25g
- Price
- $402
- Updated
- 2025/07/31
- Product number
- D418230
- Product name
- N,N-Dibenzylglycine Ethyl Ester
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 459768
- Product name
- N,N-Dibenzylglycine Ethyl Ester
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
N,N-DIBENZYLGLYCINE ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
White to almost white crystalline powder
Synthesis
623-73-4
103-49-1
77385-90-1
GENERAL STEPS: A solution of dibenzylamine (0.3 mmol, dissolved in 4.0 mL of ether) was added to a solution of water (1.0 mL) containing Ru(II)-hm-pheox 3 (0.0075 mmol, 2.5 mol%), followed by the addition of ethyl diazidoacetate (0.3 mmol, 1.0 equiv). The two-phase reaction mixture was stirred at room temperature until the reaction was complete. At the end of the reaction, the ether layer was separated and removed by decantation, and the catalyst in the aqueous phase was washed three times with ether (3 x 5.0 mL). The combined ether phases contained the ethyl 2-(dibenzylamino)acetate product, which was dried over anhydrous Na2SO4 and concentrated under reduced pressure. In most cases, the purity of the product is sufficient and no further purification is required. The aqueous phase containing the catalyst can be recovered for reuse. For purification of the 2-piperazinone product, silica gel column chromatography was used, using only methanol as eluent.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 51, p. 4750 - 4754
[2] Asian Journal of Chemistry, 2017, vol. 29, # 2, p. 349 - 352
[3] Tetrahedron Letters, 2014, vol. 55, # 40, p. 5417 - 5419
[4] Angewandte Chemie - International Edition, 2012, vol. 51, # 22, p. 5351 - 5354
[5] Tetrahedron Letters, 2009, vol. 50, # 31, p. 4467 - 4469
N,N-DIBENZYLGLYCINE ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N,N-DIBENZYLGLYCINE ETHYL ESTER manufacturers
- Product
- N,N-DIBENZYLGLYCINE ETHYL ESTER 77385-90-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-30