5-CARBOXY-N-PHENYL-2-1H-PYRIDONE
- Product Name
- 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE
- CAS No.
- 77837-08-2
- Chemical Name
- 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE
- Synonyms
- 5-Carboxy Pirfenidone;5-carboxy-N-phenyl-2-pyridone;6-oxo-1-phenylpyridine-3-carboxylic acid;1,6-Dihydro-6-oxo-1-phenyl-3-pyridinecarboxylic Acid;6-oxo-1-phenyl-1,6-dihydro-3-pyridinecarboxylic acid;6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic Acid;3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-1-phenyl-
- CBNumber
- CB6500825
- Molecular Formula
- C12H9NO3
- Formula Weight
- 215.2
- MOL File
- 77837-08-2.mol
5-CARBOXY-N-PHENYL-2-1H-PYRIDONE Property
- Melting point:
- 282-284°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Light Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C179020
- Product name
- 5-Carboxy-N-phenyl-2-1H-pyridone
- Packaging
- 50mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- FC19794
- Product name
- 5-Carboxy-N-phenyl-2-1H-pyridone
- Packaging
- 5mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC19794
- Product name
- 5-Carboxy-N-phenyl-2-1H-pyridone
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- FC19794
- Product name
- 5-Carboxy-N-phenyl-2-1H-pyridone
- Packaging
- 25mg
- Price
- $625
- Updated
- 2021/12/16
- Product number
- FC19794
- Product name
- 5-Carboxy-N-phenyl-2-1H-pyridone
- Packaging
- 50mg
- Price
- $1050
- Updated
- 2021/12/16
5-CARBOXY-N-PHENYL-2-1H-PYRIDONE Chemical Properties,Usage,Production
Chemical Properties
Off-White Fluffy Solid
Uses
A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.
Synthesis
77837-09-3
77837-08-2
General procedure for the synthesis of 6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid from methyl 6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylate: at 0 °C, lithium hydroxide monohydrate (0.366 g, 8.73 mmol) was added to a mixed solution of tetrahydrofuran (9 mL) and water (6 mL) containing methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate (1.0 g, 4.37 mmol) in a mixed solution of tetrahydrofuran (9 mL) and water (6 mL) and the reaction was stirred for 1 hour. After completion of the reaction, the reaction mixture was diluted with water and washed with ethyl acetate. Subsequently, the pH of the aqueous layer was adjusted to 2 with 2N hydrochloric acid and the precipitate was collected by filtration to afford 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid as a brown solid (0.740 g, 79% yield). The melting point of the product was 256-263°C. The structure of the product was determined by 1H NMR (400 MHz, DMSO-d6) δ 6.53 (d, J = 9.4 Hz, 1H), 7.40-7.49 (m, 5H), 7.87 (dd, J = 2.5, 9.8 Hz, 1H), 8.23 (d, J = 2.5 Hz, 1H); IR (KBr) ν 3446, 1708, 1645, 1577, 1263, 1228 cm-1; MS 214 (M-1) for characterization.
References
[1] Archiv der Pharmazie, 2013, vol. 346, # 9, p. 654 - 666
[2] Patent: US2008/319026, 2008, A1. Location in patent: Page/Page column 22
[3] Patent: WO2012/122165, 2012, A2. Location in patent: Page/Page column 63-64
[4] Patent: US2013/317059, 2013, A1. Location in patent: Paragraph 0042-0043
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 5079 - 5093
5-CARBOXY-N-PHENYL-2-1H-PYRIDONE Preparation Products And Raw materials
Raw materials
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