2-Chloro-N-MethylethanaMine Hydrochloride

Product Name: 2-Chloro-N-MethylethanaMine Hydrochloride
CAS No.: 4535-90-4
Chemical Name: 2-Chloro-N-MethylethanaMine Hydrochloride
Synonyms: 2-MethylaMinoethyl chloride HCl;(2-Chloroethyl)-methylamine HCl;2-Chloro-N-MethylethanaMine HCl;2-Chloroethyl-Methyl-Azanium Chloride;2-Chloro-N-MethylethanaMiniuM chloride;2-chloroethyl(methyl)ammonium chloride;2-chloro-n-methyl-ethylaminhydrochloride;2-chloro-n-methyl-ethanaminhydrochloride;N-Methyl-2-chloroethylaMine Hydrochloride;2-Chloro-N-MethylethylaMine Hydrochloride
CBNumber: CB6506054
Molecular Formula: C3H9Cl2N
Formula Weight: 130.01626
MOL File: 4535-90-4.mol

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2-Chloro-N-MethylethanaMine Hydrochloride Property

Melting point:: 89 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: White to off-white
InChI: InChI=1S/C3H8ClN.ClH/c1-5-3-2-4;/h5H,2-3H2,1H3;1H
InChIKey: FGSHJLJPYBUBHO-UHFFFAOYSA-N
SMILES: C(NC)CCl.Cl
EPA Substance Registry System: Ethanamine, 2-chloro-N-methyl-, hydrochloride (4535-90-4)

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Safety

HS Code: 2921199990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C428323
Product name: 2-Chloro-N-methylethanamineHydrochloride
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: V6020
Product name: 2-MethylaminoethylchlorideHCl
Packaging: 1g
Price: $14
Updated: 2021/12/16

AK Scientific

Product number: V6020
Product name: 2-MethylaminoethylchlorideHCl
Packaging: 5g
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: J53009
Product name: 2-MethylaminoethylchlorideHCl
Packaging: 25g
Price: $49
Updated: 2021/12/16

AK Scientific

Product number: V6020
Product name: 2-MethylaminoethylchlorideHCl
Packaging: 25g
Price: $67
Updated: 2021/12/16

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2-Chloro-N-MethylethanaMine Hydrochloride Chemical Properties,Usage,Production

Uses

2-Chloro-N-methylethanamine Hydrochloride is used in the preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases.

Uses

2-Chloro-N-Methylethanamine Hydrochloride is an aminoalkoxyimino derivative used in the preparation of amino derivatives of B-homoandrostanes and B-heteroandrostanes for the treatment of cardiovascular disorders.

Synthesis

109-83-1

4535-90-4

Example 2: General procedure for the synthesis of 2-chloro-N-methylethylamine hydrochloride from N-methyl-2-hydroxyethylamine 1. Dry hydrogen chloride gas was passed into a solution of dichloromethane (25 ml) containing 2-(methylamino)ethanol (10 g, 133 mmol) under stirring conditions until the mixture turned wet litmus paper red. 2. The reaction mixture was cooled to 0 °C and thionyl chloride (15.82 g, 133 mmol) was added slowly and dropwise. 3. After the dropwise addition was completed, the reaction mixture was stirred at room temperature overnight. 4. After completion of the reaction, the solvent was removed by distillation under reduced pressure to afford the target product 2-chloro-N-methylethylamine hydrochloride as a white solid (16.60 g, 96% yield). Product characterization: melting point 95°-100°C; 1H NMR (DMSO-d6) δ 4.00 (t, 2H, J = 6.28Hz), 3.36 (t, 2H, J = 6.29Hz), 2.81 (s, 3H); IR (KBr) ν 3400, 2960, 2750, 2420, 1730, 1580, 1460, 1390, 1310, 1270, 1200, 1310, 1270, 1200, 1390, 1390. 1310, 1270, 1200, 1150, 1165, 1005, 990, 900, 860, 710 cm-1.

References

[1] Journal of Medicinal Chemistry, 1995, vol. 38, # 14, p. 2672 - 2680
[2] Patent: US5233031, 1993, A
[3] Chemical and Pharmaceutical Bulletin, 2002, vol. 50, # 7, p. 941 - 959
[4] Journal of the Chemical Society. Dalton Transactions, 2001, # 8, p. 1306 - 1318
[5] Journal of medicinal chemistry, 1992, vol. 35, # 17, p. 3246 - 3253

2-Chloro-N-MethylethanaMine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methylpiperazin-2-one

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2-Chloro-N-MethylethanaMine Hydrochloride Suppliers

China 98 India 2 United States 5 Global 105

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View Lastest Price from 2-Chloro-N-MethylethanaMine Hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-N-MethylethanaMine Hydrochloride 4535-90-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-N-MethylethanaMine Hydrochloride 4535-90-4
Price: US $25.00-11.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-12

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-N-MethylethanaMine Hydrochloride 4535-90-4
Price: US $5.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

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2-Chloro-N-MethylethylaMine Hydrochloride

N-Methyl-2-chloroethylaMine Hydrochloride

2-Chloro-N-MethylethanaMine HCl

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2-Chloro-N-MethylethanaMiniuM chloride

EthanaMine,2-chloro-N-Methyl-, hydrochloride (1:1)

2-Chloroethyl-Methyl-Azanium Chloride

2-Methylaminoethyl Chloride Hydrochloride 2-Chloroethyl-Methyl-Ammonium Chloride

2-N-Methylaminoethyl chloride hydrohloride

(2-Chloroethyl)-methylamine HCl

4535-90-4

CH3NHCH2CH2ClHCl

Amines, Intermediates