ChemicalBook > CAS DataBase List > H1152, DIHYDROCHLORIDE

H1152, DIHYDROCHLORIDE

Product Name
H1152, DIHYDROCHLORIDE
CAS No.
871543-07-6
Chemical Name
H1152, DIHYDROCHLORIDE
Synonyms
H-1152 2HCl;H1152, DIHYDROCHLORIDE;H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline;H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride;H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride
CBNumber
CB6506731
Molecular Formula
C16H21N3O2S
Formula Weight
319.42184
MOL File
871543-07-6.mol
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H1152, DIHYDROCHLORIDE Property

Melting point:
182-184°C
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Methanol, Water
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
555550
Product name
Rho Kinase Inhibitor - Calbiochem
Purity
TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
Packaging
1mg
Price
$324
Updated
2024/03/01
Sigma-Aldrich
Product number
555550
Product name
Rho Kinase Inhibitor - Calbiochem
Purity
TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
Packaging
5mg
Price
$659
Updated
2024/03/01
Tocris
Product number
2414
Product name
H1152dihydrochloride
Purity
≥98%(HPLC)
Packaging
1
Price
$231
Updated
2021/12/16
TRC
Product number
H011520
Product name
H-1152Dihydrochloride
Packaging
5mg
Price
$150
Updated
2021/12/16
TRC
Product number
H011520
Product name
H-1152Dihydrochloride
Packaging
25mg
Price
$695
Updated
2021/12/16
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H1152, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.

Definition

ChEBI: (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride is a hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It contains a (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane(2+).

General Description

A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 μg/128 μl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H2O is also available.

Biochem/physiol Actions

Primary TargetROCK

storage

Desiccate at +4°C

H1152, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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H1152, DIHYDROCHLORIDE Suppliers

Canada 1 China 33 Germany 1 India 1 United Kingdom 2 United States 11 Global 49
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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021-50135380
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shchemsky@sina.com
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China
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Haoyuan Chemexpress Co., Ltd.
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(86) 21-58955996
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Shanghai Rechem science Co., Ltd.
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21-31433387 15618786686
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010-50973130 4009686088
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871543-07-6, H1152, DIHYDROCHLORIDERelated Search:


  • 4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline
  • 5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline
  • H1152, DIHYDROCHLORIDE
  • H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride
  • H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride
  • H-1152 2HCl
  • H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE
  • 871543-07-6
  • C16H23Cl2N3O2S
  • Protein Kinase Inhibitors and Activators
  • Inhibitors
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