Bosentan hydrate
- Product Name
- Bosentan hydrate
- CAS No.
- 157212-55-0
- Chemical Name
- Bosentan hydrate
- Synonyms
- CS-170;Bosetan;bosentan hydrate;Bosentan (200 mg);Bosentan (1076115);Bosentan monohydrate;Bosentan hydrate USP/EP/BP;Bosentan Hydrate See B675900;Bosentan Hydrate (Ro 47-0203);Tracleer, Bosentan monohydrate
- CBNumber
- CB6547457
- Molecular Formula
- C27H31N5O7S
- Formula Weight
- 569.62934
- MOL File
- 157212-55-0.mol
Bosentan hydrate Property
- Melting point:
- 114-118 °C
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly, Heated)
- form
- powder
- color
- white to beige
- Merck
- 14,1353
Safety
- HS Code
- 2935909550
N-Bromosuccinimide Price
- Product number
- SML1265
- Product name
- Bosentan hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $108
- Updated
- 2023/06/20
- Product number
- SML1265
- Product name
- Bosentan hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $438
- Updated
- 2023/06/20
- Product number
- PHR2708
- Product name
- Bosentan
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 500MG
- Price
- $349
- Updated
- 2022/05/15
- Product number
- 1076115
- Product name
- Bosentan
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200MG
- Price
- $818
- Updated
- 2022/05/15
- Product number
- B5118
- Product name
- Bosentan Monohydrate
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $57
- Updated
- 2024/03/01
Bosentan hydrate Chemical Properties,Usage,Production
Uses
Antagonist (endothelin receptor).
Uses
Bosentan hydrate has been used in cell viability assay. It has also been used as a positive control for calcium transient analysis.
Definition
ChEBI: Bosentan hydrate is a hydrate. It contains a bosentan.
brand name
Tracleer (Actelion).
Biological Activity
a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a relatively higher affinity to the endothelin a receptor than endothelin b receptor. by competitively binding to endothelin a and endothelin b receptors in the endothelium and vascular smooth muscle, bosentan offset the effect of endothelin which is an extremely potent endogenous vasoconstrictor and broncho-constrictor. in addition, bosentan decreases both pulmonary and systemic vascular resistance and is particularly applied in the treatment of pulmonary arterial hypertension. [1]
Biochem/physiol Actions
Bosentan is an endothelin receptor antagonist. Endothelin is a potent vasoconstrictor, making antagonists of clinical interest for the treatment of conditions associated with vasospasm, such as subarachnoid hemorrhage (SAH) and hypertension. Bosentan is a dual endothelin receptor antagonist effective in the treatment of pulmonary arterial hypertension (PAH), the first of the class to make it to market. Bosentan is an orally available, competitive antagonist of both the ETA and ETB receptor subtypes with a Ki of 4.7 nM for ETA and a Ki of 95 nM for ETB.
in vitro
a study was performed in vitro to measure the influence of bosentan on the angiogenic performance of dermal microvascular endothelial cells (mvecs) and to detect the capacity of bosentan in offsetting the antiangiogenic effects of systemic sclerosis sera. it was found that bosentan significantly increased cell viability and offset the antiangiogenic effects of systemic sclerosis sera on dermal mvecs. [2]
in vivo
a study was conducted to investigate the effect of bosentan on plasma leptin level after myocardial infarction in wistar rats. after oral administration of bosentan once daily at the dose of 100 mg/kg for 2 days, concentration of leptin in plasma significantly increased. this finding revealed that bosentan played an crucial role on regulating leptin concentration in ischemic cardiovascular pathology. [1]
IC 50
inhibiting endothelin receptor a and b with an ic50 of 15.1 ± 1.6 μm in p388/dx cells.
References
[1] ostrowski rp, januszewski sa, kowalska za and kapuscinski a. effect of endothelin receptor antagonist bosentan on plasma leptin concentration in acute myocardial infarction in rats. pathophysiology. 2003 sep; 9(4): 249-56.
[2]romano e, bellando-randone s, manetti m, bruni c, lepri g, matucci-cerinic m, guiducci s. bosentan blocks the antiangiogenic effects of sera from systemic sclerosis patients: an in vitro study. clin exp rheumatol. 2015 aug; 33(4 suppl 91): s148-52.
[3]rubin lj, badesch db, barst rj, galiè n, black cm et, al. bosentan therapy for pulmonary arterial hypertension. new engl j med. 2002 mar; 346 (12): 896-903.
Bosentan hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Bosentan hydrate Suppliers
- Tel
- 027-83778876 13667159345
- Fax
- 027-83778876
- 13667159345@163.com
- Country
- China
- ProdList
- 1941
- Advantage
- 55
- Tel
- 17762444226
- d17762444226@163.com
- Country
- China
- ProdList
- 2402
- Advantage
- 58
- Tel
- 185-0276-2003 18502762003;
- 435918333@qq.com
- Country
- China
- ProdList
- 2243
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94838
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 0512-68716880 18075373931
- Fax
- 18075373931
- sales@growingchem.com
- Country
- China
- ProdList
- 74
- Advantage
- 64
- Tel
- 021-021-64543801 13764082696
- 2355241799@qq.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 13355009207 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18739
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9823
- Advantage
- 79
- Tel
- 510-83782303 13771177691
- Fax
- 0510- 8378-9906
- sales@itppharm.com
- Country
- China
- ProdList
- 107
- Advantage
- 62
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4664
- Advantage
- 58
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9725
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1494
- Advantage
- 55
- Tel
- 13901585132
- Fax
- +86-25-52131256
- 799750417@qq.com
- Country
- China
- ProdList
- 8888
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25014
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9552
- Advantage
- 55
- Tel
- +86(0)21 60484900
- Fax
- +86(0)21 60484900
- Country
- China
- ProdList
- 764
- Advantage
- 50
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8033
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3750
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 27-81302488 18007166089
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 2024
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3123
- Advantage
- 55
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 021-54359730 400-008-9730
- Fax
- 021-54353864
- info@chemxyz.com
- Country
- China
- ProdList
- 3993
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9352
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13359
- Advantage
- 58
- Tel
- 400-6087598 15021221957
- Fax
- 4006087598-8012
- order@canspecsci.com
- Country
- China
- ProdList
- 2071
- Advantage
- 56
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4951
- Advantage
- 58
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- 028-85305008 02885305008
- Fax
- 4000210878-186
- 2306208234@qq.com
- Country
- China
- ProdList
- 1005
- Advantage
- 50
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9503
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4901
- Advantage
- 55
- Tel
- 027-027-59207879 18140587686
- Fax
- QQ：1972026995
- kf@3600chem.com
- Country
- China
- ProdList
- 4697
- Advantage
- 55
- Tel
- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
- Country
- China
- ProdList
- 991
- Advantage
- 55
- Tel
- 21-619849051-1 18016477331
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6456
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 0571-0571-87157530-8001-8006 18049756717
- Fax
- 0571-87156470
- sales@dingyanchem.com
- Country
- China
- ProdList
- 1997
- Advantage
- 58
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10457
- Advantage
- 58
- Tel
- 19138486554 18582380095
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 2862
- Advantage
- 58
- Tel
- 86 512-62572107 62962707
- Fax
- 86 512-62922078
- Country
- China
- ProdList
- 800
- Advantage
- 58
View Lastest Price from Bosentan hydrate manufacturers
- Product
- Bosentan hydrate 157212-55-0
- Price
- US $0.20/g
- Min. Order
- 100g
- Purity
- 99.99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-26
- Product
- Bosentan hydrate 157212-55-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%+
- Supply Ability
- 100kgs
- Release date
- 2021-05-24
- Product
- Bosentan hydrate 157212-55-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10