Adenosine 5'-diphosphoribose sodium salt

Product Name: Adenosine 5'-diphosphoribose sodium salt
CAS No.: 68414-18-6
Chemical Name: Adenosine 5'-diphosphoribose sodium salt
Synonyms: adp-ribose;ADP ribose sodium;adenosine 5'-diphosphoribose sodium;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;Adenosine 5'-diphosphoribose sodium salt >=93%;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE;Adenosine 5′diphosphoribose sodium,Adenosine 5′ diphosphoribose sodium;[[5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL] (2,3,4-TRIHYDROXY-5-OXOPENTYL) HYDROGEN PHOSPHATE,SODIUM
CBNumber: CB6667689
Molecular Formula: C15H24N5NaO14P2
Formula Weight: 583.32
MOL File: 68414-18-6.mol

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Adenosine 5'-diphosphoribose sodium salt Property

storage temp.: -20°C
Water Solubility: Water : 125 mg/mL (215.04 mM)
InChIKey: MBPRZUBFEMLFGQ-UUIVKEFHSA-M
SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r|

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0752
Product name: Adenosine 5′-diphosphoribose sodium salt
Purity: ≥93%
Packaging: 25mg
Price: $97.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0752
Product name: Adenosine 5′-diphosphoribose sodium salt
Purity: ≥93%
Packaging: 100mg
Price: $298
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0752
Product name: Adenosine 5′-diphosphoribose sodium salt
Purity: ≥93%
Packaging: 500mg
Price: $1180
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: NUC0000507
Product name: ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE
Purity: 95.00%
Packaging: 500MG
Price: $1286.73
Updated: 2021/12/16

ChemScene

Product number: CS-0020654
Product name: Adenosine5′-diphosphoribose(sodium)
Purity: ≥98.0%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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Adenosine 5'-diphosphoribose sodium salt Chemical Properties,Usage,Production

Description

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator and can also enhance autophagy.

Uses

5′-Deoxy-5′-(methylthio)adenosine has been used:

to give a range of nicotinamide adenine dinucleotide (NADH)
oxidation rates for the respiratory complex (CI/CIII/CIV)
CI/alternative(AOX) pathway
to measure poly(ADP-ribose) glycohydrolaseactivity
poly(ADP-ribose) (PAR) binding competition assay
oxidase?(AOX) pathway
to measure poly(ADP-ribose) glycohydrolase activity
poly(ADP-ribose) (PAR) binding competition assay

Biochem/physiol Actions

ADP-Ribose is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are an important components of DNA repair and apoptosis signaling.

in vitro

In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.

Adenosine 5'-diphosphoribose sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Adenosine 5'-diphosphoribose sodium salt Suppliers

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68414-18-6, Adenosine 5'-diphosphoribose sodium saltRelated Search:

2,4-DICHLORO-OMEGA-NITROSTYRENE ADP ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT

ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT

ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE

adp-ribose

adenosine 5'-diphosphoribose sodium

ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE

[[5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL] (2,3,4-TRIHYDROXY-5-OXOPENTYL) HYDROGEN PHOSPHATE,SODIUM

ADP ribose sodium

Adenosine 5'-diphosphoribose sodium salt >=93%

Adenosine 5′diphosphoribose sodium,Adenosine 5′ diphosphoribose sodium

ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT

68414-18-6

C15H22N5NaO14P2

C15H22N5O14P2Na

C15H22N5O14P2Na2H2O

BioChemical

Acyl Transfer Reagents

Biochemicals and Reagents

Enzymes, Inhibitors, and Substrates

Cofactors