Adenosine 5'-diphosphoribose sodium salt
- Product Name
- Adenosine 5'-diphosphoribose sodium salt
- CAS No.
- 68414-18-6
- Chemical Name
- Adenosine 5'-diphosphoribose sodium salt
- Synonyms
- adp-ribose;ADP ribose sodium;adenosine 5'-diphosphoribose sodium;Adenosine 5'-diphosphoribose sodium;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;Adenosine 5'-diphosphoribose sodium salt >=93%;ADPR, Adenosine 5 '- diphosphate ribose sodium;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE
- CBNumber
- CB6667689
- Molecular Formula
- C15H22N5NaO14P2
- Formula Weight
- 581.3
- MOL File
- 68414-18-6.mol
Adenosine 5'-diphosphoribose sodium salt Property
- storage temp.
- -20°C
- form
- Solid
- color
- White to light yellow
- Water Solubility
- Water : 125 mg/mL (215.04 mM)
- InChIKey
- MBPRZUBFEMLFGQ-UUIVKEFHSA-M
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A0752
- Product name
- Adenosine 5′-diphosphoribose sodium salt
- Purity
- ≥93%
- Packaging
- 25mg
- Price
- $97.6
- Updated
- 2024/03/01
- Product number
- A0752
- Product name
- Adenosine 5′-diphosphoribose sodium salt
- Purity
- ≥93%
- Packaging
- 100mg
- Price
- $298
- Updated
- 2024/03/01
- Product number
- A0752
- Product name
- Adenosine 5′-diphosphoribose sodium salt
- Purity
- ≥93%
- Packaging
- 500mg
- Price
- $1180
- Updated
- 2024/03/01
- Product number
- NUC0000507
- Product name
- ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1286.73
- Updated
- 2021/12/16
- Product number
- CS-0020654
- Product name
- Adenosine5′-diphosphoribose(sodium)
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
Adenosine 5'-diphosphoribose sodium salt Chemical Properties,Usage,Production
Description
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator and can also enhance autophagy.
Uses
5′-Deoxy-5′-(methylthio)adenosine has been used:
- to give a range of nicotinamide adenine dinucleotide (NADH)
- oxidation rates for the respiratory complex (CI/CIII/CIV)
- CI/alternative(AOX) pathway
- to measure poly(ADP-ribose) glycohydrolaseactivity
- poly(ADP-ribose) (PAR) binding competition assay
- oxidase?(AOX) pathway
- to measure poly(ADP-ribose) glycohydrolase activity
- poly(ADP-ribose) (PAR) binding competition assay
Biochem/physiol Actions
ADP-Ribose is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are an important components of DNA repair and apoptosis signaling.
in vitro
In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.
Adenosine 5'-diphosphoribose sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
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