2,4-Difluorophenylacetic acid
- Product Name
- 2,4-Difluorophenylacetic acid
- CAS No.
- 81228-09-3
- Chemical Name
- 2,4-Difluorophenylacetic acid
- Synonyms
- 2,4-difluoro acid;RARECHEM AL BO 0247;Sitagliptin Impurity 119;2,4-two fluorineacetic acid;2,4-DIFLUOROPHENYLACETIC ACID;2-(2,4-DIFLUOROPHENYL)ACETATE;2,4-Difluorophenylaceticacid97%;2,4-DifluorophenylaceticAcid>2,4-Difluorophenylaceticacid,99%;2-(2,4-difluorophenyl)acetic acid
- CBNumber
- CB6671039
- Molecular Formula
- C8H6F2O2
- Formula Weight
- 172.13
- MOL File
- 81228-09-3.mol
2,4-Difluorophenylacetic acid Property
- Melting point:
- 115-118 °C (lit.)
- Boiling point:
- 219°C (rough estimate)
- Density
- 1.3010 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- 3.98±0.10(Predicted)
- color
- White
- BRN
- 3649727
- InChI
- InChI=1S/C8H6F2O2/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4H,3H2,(H,11,12)
- InChIKey
- QPKZIGHNRLZBCL-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(F)C=C1F
- CAS DataBase Reference
- 81228-09-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,4-Difluorophenylacetic acid(81228-09-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 264474
- Product name
- 2,4-Difluorophenylacetic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $28.97
- Updated
- 2025/07/31
- Product number
- D4321
- Product name
- 2,4-Difluorophenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $109
- Updated
- 2025/07/31
- Product number
- D4321
- Product name
- 2,4-Difluorophenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $369
- Updated
- 2025/07/31
- Product number
- D445405
- Product name
- 2,4-DifluorobenzeneaceticAcid
- Packaging
- 25g
- Price
- $290
- Updated
- 2021/12/16
- Product number
- JK200555
- Product name
- 2,4-Difluorophenylacetic Acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $487
- Updated
- 2021/12/16
2,4-Difluorophenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
2,4-Difluorophenylacetic acid is used in the synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics (F-PNA).
Uses
2,4-Difluorophenylacetic acid has been used in the synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics (F-PNA).
Synthesis
23915-07-3
81228-09-3
(a) 25.7 g of 2,4-difluorobenzyl bromide was dissolved in 100 mL of tetrahydrofuran and slowly added dropwise over 0.5 h to a stirred suspension containing 3.0 g of magnesium chips and 30 mL of tetrahydrofuran. After the dropwise addition was completed, stirring of the reaction mixture was continued for 10 minutes. Subsequently, a steady stream of carbon dioxide was continuously passed into the resulting Grignard reagent for 1 hour. After completion of the reaction, the mixture was evaporated to dryness and the residue was partitioned with ether and dilute hydrochloric acid. The ether phase was separated and extracted with 2 N sodium hydroxide solution. The basic extract was acidified with concentrated hydrochloric acid and extracted with ether to give 5.1 g (24% yield) of crude 2,4-difluorophenylacetic acid. The crude product was dissolved directly in 25 mL of tetrahydrofuran without further purification and added slowly dropwise to a stirred mixture of 2.0 g of lithium aluminum hydride suspended in 100 mL of tetrahydrofuran.
References
[1] Patent: US4649160, 1987, A
2,4-Difluorophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Difluorophenylacetic acid manufacturers
- Product
- 2,4-Difluorophenylacetic acid 81228-09-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- 2,4-Difluorophenylacetic acid 81228-09-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-23
- Product
- 2,4-Difluorophenylacetic acid 81228-09-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09