ChemicalBook > CAS DataBase List > 2,4-Thiazolidinedione

2,4-Thiazolidinedione

Product Name
2,4-Thiazolidinedione
CAS No.
2295-31-0
Chemical Name
2,4-Thiazolidinedione
Synonyms
THIAZOLIDINE-2,4-DIONE;TZD;Thiazolidinedione;2,4-Thiazolidindione;U 25560;idinedione;usafek-5496;2,4-ThiazoL;USAF ek-5496;AURORA 23272
CBNumber
CB6675365
Molecular Formula
C3H3NO2S
Formula Weight
117.13
MOL File
2295-31-0.mol
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2,4-Thiazolidinedione Property

Melting point:
125-127 °C (lit.)
Boiling point:
178-179 °C (19 mmHg)
Density 
1.408 (estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5130 (estimate)
Flash point:
178-179°C/19mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
pka
6.50±0.10(Predicted)
color 
Slightly yellow
Water Solubility 
Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.
BRN 
110700
InChIKey
ZOBPZXTWZATXDG-UHFFFAOYSA-N
LogP
-0.29 at 25℃
CAS DataBase Reference
2295-31-0(CAS DataBase Reference)
NIST Chemistry Reference
2,4-Thiazolidinedione(2295-31-0)
EPA Substance Registry System
2,4-Thiazolidinedione (2295-31-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
XJ5775000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29341000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
375004
Product name
2,4-Thiazolidinedione
Purity
technical grade, 90%
Packaging
25g
Price
$79
Updated
2024/03/01
Sigma-Aldrich
Product number
375004
Product name
2,4-Thiazolidinedione
Purity
technical grade, 90%
Packaging
100g
Price
$123
Updated
2024/03/01
TCI Chemical
Product number
T1990
Product name
2,4-Thiazolidinedione
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
T1990
Product name
2,4-Thiazolidinedione
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$51
Updated
2024/03/01
Alfa Aesar
Product number
A13496
Product name
2,4-Thiazolidinedione, 99%
Packaging
25g
Price
$59.65
Updated
2024/03/01
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2,4-Thiazolidinedione Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

Inhibitor of enzyme

Uses

2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.

Definition

ChEBI: A thiazolidenedione carrying oxo substituents at positions 2 and 4.

General Description

2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.

Flammability and Explosibility

Not classified

2,4-Thiazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

Thiazole-5-carboxaldehyde Thiazole-4-carboxaldehyde Rosiglitazone
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2,4-Thiazolidinedione Suppliers

Austria 2 Belgium 1 Canada 6 China 410 Czech 1 Europe 2 France 2 Germany 8 India 73 Japan 8 Russia 1 Slovakia 1 South Korea 2 Switzerland 4 Ukraine 3 United Kingdom 22 United States 55 Global 601
Loba Feinchemie AG
Tel
--
Fax
--
Email
sales@loba.co.at
Country
Austria
ProdList
900
Advantage
61
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View Lastest Price from 2,4-Thiazolidinedione manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
2,4-Thiazolidinedione 2295-31-0
Price
US $65.00-650.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-20
Hebei Yanxi Chemical Co., Ltd.
Product
2,4-Thiazolidinedione 2295-31-0
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-17
Hebei Mojin Biotechnology Co., Ltd
Product
2,4-Thiazolidinedione 2295-31-0
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2021-10-09

2295-31-0, 2,4-ThiazolidinedioneRelated Search:

Fosthiazate Benzothiazole 2-Methyl-4-isothiazolin-3-one THIAZOLIDINE Thiazole 2,5-Dimethylpyrrolidine Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 5a-Androstanedione N-Methyl-2-pyrrolidone Polyvinylpyrrolidone 5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione Pioglitazone hydrochloride 3-ETHYLRHODANINE 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione sodium salt 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide Pioglitazone 2,4-thiazolidinedione,5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1- 2,4-Thiazolidinedione, 2-thio-,2,4-thiazolidinedione,2-thio-[qr

  • 2,4-Thiazolidinedione, 99% 100GR
  • 2,4-Thiazolidinedione, 99% 25GR
  • thiazolidin-2,4-dione
  • 2,4-Thiazolidinedione technical grade, 90%
  • 2, 4 - Margaret diketone
  • OTAVA-BB BB7112440002
  • TZD
  • TIMTEC-BB SBB000047
  • THIAZOLIDINE-2,4-DIONE
  • 2,4(3H,5H)-Thiazoledione
  • 2,4-Dioxothiazolidine
  • Thiazolidinedione
  • Thiazolidinedione-2,4
  • USAF ek-5496
  • usafek-5496
  • AURORA 23272
  • 2,3,4,5-TETRAHYDROTHIAZOLE-2,4-DIONE
  • 1,3-Thiazolane-2,4-dione
  • 1,3-Thiazolane-2,4-dione, 2,4-Dioxo-1,3-thiazolidine
  • 2,4-ThiazoL
  • idinedione
  • 1,3-THIAZOLIDINE-2,4-DIONE
  • 2,4-DIKETOTHIAZOLIDINE
  • 2,4-THIAZOLIDINEDIONE
  • 2,4-Thiazolidinedione 、Thiazolidine-2,4-dione
  • AKOS B029064
  • 2,4-Thiadolidinedione
  • 2,4(3H,5H)-Thiazoledion
  • U 25560
  • 2,4-Thiazolidinedione ,99%
  • 2,4-Thiazolinedione
  • 2,4-THIAZOLIDINEDIONE, TECH., 90%
  • 2,4-Thiazolidindione
  • 2,4-Thiazolidondione
  • 2,4-Thiozolidinedione
  • 1,3-Thiazolidine-2,4-dione 98%
  • Thiazoline-2,4-dione(2,4-thiazolidinedion)
  • 2,4-THIAZOLIDINEDIONE 98%
  • 2,4-THIZAOLODINE
  • 2,4-Thiazolidinedione &gt
  • 2,4-Thiazolidinedione (P)
  • Thiazolidin-2,4-dion
  • Thiazolidinedione (6CI)
  • Pioglitazone impurity thiazolidine-2,4-dione
  • 2295-31-0
  • 2295-31-2
  • C3H3NO2S
  • C3H2KNO2S
  • Building Blocks
  • Heterocyclic Building Blocks
  • Thiazoles
  • Thiazolines/Thiazolidines
  • Starting Raw Materials & Intermediates
  • PHARMACEUTICAL INTERMEDIATES
  • Sulphur Derivatives
  • Sulfur compounds
  • blocks
  • Heterocycles