N-Methyl-L-prolinol

Uses

Product Name: N-Methyl-L-prolinol
CAS No.: 34381-71-0
Chemical Name: N-Methyl-L-prolinol
Synonyms: (S)-(1-Methylpyrrolidin-2-yl)Methanol;(S)-1-METHYL-2-PYRROLIDINEMETHANOL;[(2S)-1-Methylpyrrolidin-2-yl]Methanol;N-METHYLPROLINOL;(S)-(-)-1-MethyL;N-METHYL-L-PROLINOL;1-METHYL-L-PROLINOL;N-methylI-L-prolinol;N-METHYL-L-PYRROLINOL;N-Methyl-L-Prolinol HCl
CBNumber: CB6675789
Molecular Formula: C6H13NO
Formula Weight: 115.17
MOL File: 34381-71-0.mol

More

Less

N-Methyl-L-prolinol Property

Boiling point:: 67-69 °C12 mm Hg(lit.)
alpha: -49.5 º (c=5, MeOH)
Density: 0.968 g/mL at 25 °C(lit.)
refractive index: n20/D 1.469(lit.)
Flash point:: 146 °F
storage temp.: 2-8°C
form: Liquid
pka: 14.77±0.10(Predicted)
color: Colorless to yellow
optical activity: [α]19/D 49.5°, c = 5 in methanol
BRN: 79851
InChI: InChI=1S/C6H13NO/c1-7-4-2-3-6(7)5-8/h6,8H,2-5H2,1H3/t6-/m0/s1
InChIKey: VCOJPHPOVDIRJK-LURJTMIESA-N
SMILES: N1(C)CCC[C@H]1CO
CAS DataBase Reference: 34381-71-0(CAS DataBase Reference)
NIST Chemistry Reference: N-Methyl-L-prolinol(34381-71-0)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 23-24/25-36-26
WGK Germany: 3
F: 8-10-23
HazardClass: IRRITANT
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H227Combustible liquid
Precautionary statements: P403+P235Store in a well-ventilated place. Keep cool.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 302767
Product name: (S)-(?)-1-Methyl-2-pyrrolidinemethanol
Purity: 96%
Packaging: 5g
Price: $85.01
Updated: 2025/07/31

Sigma-Aldrich

Product number: 302767
Product name: (S)-(?)-1-Methyl-2-pyrrolidinemethanol
Purity: 96%
Packaging: 25g
Price: $386.14
Updated: 2025/07/31

TCI Chemical

Product number: M2058
Product name: (S)-(1-Methylpyrrolidin-2-yl)methanol
Purity: min. 98.0 %
Packaging: 5G
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: M2058
Product name: (S)-(1-Methylpyrrolidin-2-yl)methanol
Purity: min. 98.0 %
Packaging: 25G
Price: $125
Updated: 2025/07/31

TRC

Product number: M339030
Product name: (S)-(-)-1-Methyl-2-pyrrolidinemethanol
Packaging: 10g
Price: $105
Updated: 2021/12/16

More

Less

N-Methyl-L-prolinol Chemical Properties,Usage,Production

Uses

N-Methyl-L-prolinol is a reagent used in the synthesis of novel 4-hydroxytamoxifen analogs used as estrogen-related receptor γ (ERRγ) inverse agonists.

Chemical Properties

white to light yellow crystal powde

Uses

Precursor to phosphine ligands for catalytic asymmetric Grignard cross-coupling reactions.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

147-85-3

34381-71-0

(2) 5.0 g (0.0434 mol) of L-proline was dissolved in 92 mL of 97% formic acid and the reaction temperature was maintained at 5°C-10°C. 30 mL of acetic anhydride was added slowly and the reaction mixture was stirred continuously for 2 hours. After completion of the reaction, the reaction was quenched by adding 35 mL of ice water at room temperature. The solvent was removed by evaporation to afford (S)-(-)-N-formylproline ([α]D2?: -105°, c = 2.885, methanol), the product was a clarified, viscous, light yellow oil, which could be used for the next reaction without further purification. Under nitrogen protection, 20 mL of tetrahydrofuran solution of (S)-(-)-N-formylproline was slowly added to 125 mL of tetrahydrofuran suspension of 8.23 g (0.217 mol) of lithium aluminium hydride, and the rate of addition was controlled to maintain mild reflux. After addition, the reaction was continued at reflux for 48 hours. At the end of the reaction, it was cooled to room temperature and the reaction was quenched by careful addition of 8.3 mL of water, 8.3 mL of 15% aqueous sodium hydroxide solution and 25 mL of water in that order. The off-white mixture obtained was filtered and the filtrate was dried over magnesium sulfate and concentrated to an oil. Purification by bulb-to-bulb distillation (oven temperature 40°C-55°C, 0.15 Torr) afforded 2.823 g of N-methyl-L-prolinol in 57% yield (as L-proline).

References

[1] Patent: US4321387, 1982, A
[2] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 19, p. 2891 - 2896
[3] Tetrahedron Letters, 1995, vol. 36, # 43, p. 7885 - 7888
[4] Journal of the American Chemical Society, 1991, vol. 113, # 24, p. 9286 - 9292
[5] Tetrahedron Letters, 1983, vol. 24, # 33, p. 3513 - 3516

N-Methyl-L-prolinol Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Methyl-L-prolinol Suppliers

China 241 Europe 1 Germany 2 India 6 Japan 1 Switzerland 1 United Kingdom 6 United States 25 Global 283

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3343
Advantage: 50

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

ChemContract Research Inc.

Tel: --
Fax: --
Country: United States
ProdList: 1526
Advantage: 38

Anvia Chemicals, LLC

Tel: --
Fax: --
Email: sales@anviachem.com
Country: United States
ProdList: 3933
Advantage: 0

Pure Chemistry Scientific Inc

Tel: --
Fax: --
Email: sales@purechems.com
Country: United States
ProdList: 2321
Advantage: 50

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

ECA International Corporation

Tel: --
Fax: --
Email: services@ecacorporation.com
Country: United States
ProdList: 1062
Advantage: 52

Asymchem Laboratories, Inc.

Tel: --
Fax: --
Email: info@asymchem.com
Country: United States
ProdList: 1315
Advantage: 69

More

Less

View Lastest Price from N-Methyl-L-prolinol manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: (S)-Methylpyrrolidine-2-methanol 34381-71-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-29

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-Methyl-L-prolinol 34381-71-0
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Methyl-L-prolinol 34381-71-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

34381-71-0, N-Methyl-L-prolinolRelated Search:

2,2,6,6-Tetramethyl-4-piperidinol L-(+)-Prolinol Polyvinylpyrrolidone 1-Methylpyrrolidine Methyl acetate Methyl acrylate N-Methyl-2-pyrrolidone Kresoxim-methyl Methylparaben METHYLCYCLOHEXANOL METSULFURON METHYL Bensulfuron methyl Thiophanate-methyl Methyl GLYCYL-L-PROLINE SWAINSONINE Methyl bromide Parathion-methyl

(2S)-1-Methyl-2-pyrrolidinemethanol

(2S)-1-Methyl-2α-(hydroxymethyl)pyrrolidine

(2S)-1-Methyl-2α-pyrrolidinemethanol

(2S)-1-Methylpyrrolidine-2α-methanol

(S)-(+)-1-methyl-prolinol

(S)-(-)-2-HYDROXYMETHYL-1-METHYLPYRROLID

(S)-(1-Methylpyrrolidin-2-yl)Methanol

(S)-(-)-1-Methyl-2-pyrrolidinemethanol 96%

[(2S)-1-Methylpyrrolidin-2-yl]Methanol

(S)-(-)-1-Methyl-2-pyrrrolidinemethanol

2-Pyrrolidinemethanol, 1-methyl-, (S)-

(S)-(-)-1-METHYL-2-PYRROLIDINEMETHANOL

(S)-1-METHYL-2-PYRROLIDINEMETHANOL

(S)-(-)-(1-METHYL-2-PYRROLIDINYL)METHANOL

(S)-(-)-1-METHYLPYRROLIDINE-2-METHANOL

(S)-1-METHYLPYRROLIDINE-2-METHANOL

(S)-(-)-2-HYDROXYMETHYL-1-METHYLPYRROLIDINE

(S)-2-HYDROXYMETHYL-1-METHYLPYRROLIDINE

N-METHYLPROLINOL

N-METHYL-L-PROLINOL

N-METHYL-L-PYRROLINOL

(S)-methylpyrrolidine-2-methanol

N-Methyl-L-Prolinol HCl

1-METHYL-L-PROLINOL

2-Pyrrolidinemethanol, 1-methyl-, (2S)-

(S)-(-)-1-Methyl-2-pyrrolidinemethan

(S)-(-)-2-HYDROXYMETHYL-1-METHYLPYRROLIDINE 98+%

(S)-N-Methylpyrrolidine-2-methanol

(S)-(-)-1-Methylpyrrolidine-2-methano

(S)-(-)-1-methanol-2-pyrrolidinemethanol

(S)-2-Hydroxymethyl-1-methylpyrrolidine, N-Methyl-L-prolinol

(S)-(-)-1-MethyL

N-Methyl-L-prolinol USP/EP/BP

S-1-Methyl-2-pyrrollidinemethanol

34381-71-0 N-Methyl-L-prolinol

N-Methyl-L-Prolinol (S)-(1-Methylpyrrolidin-2-yl)methanol

N-methylI-L-prolinol

(<i>S</i>)-(?)-1-Methyl-2-pyrrolidinemethanol

(S)-(–)-1-Methyl-2-pyrrolidinemethanol, CAS 34381-71-0

34381-71-0

4381-71-0

Specialty Synthesis

Peptide Synthesis

Amino Alcohols

Amino Acid Derivatives

chiral

Chiral Reagent