ChemicalBook > CAS DataBase List > 2-(Diphenylphosphino)benzoic acid

2-(Diphenylphosphino)benzoic acid

Product Name: 2-(Diphenylphosphino)benzoic acid
CAS No.: 17261-28-8
Chemical Name: 2-(Diphenylphosphino)benzoic acid
Synonyms: 2-(DiphenyL;phosphino)benzoic acid;2-Diphenylphosphinobenzoic;Diphenylphosphinobenzoic acid;2-Diphenylphosphinobenzoes?ure;2-Carboxyphenyldiphenylphosphine;2-Diphenylphosphanyl-benzoicacid;2-(diphenylphosphino)-benzoicaci;2-(DIPHENYLPHOSPHINO)BENZOIC ACID;O-(DIPHENYLPHOSPHINO)BENZOIC ACID
CBNumber: CB6676973
Molecular Formula: C19H15O2P
Formula Weight: 306.3
MOL File: 17261-28-8.mol

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2-(Diphenylphosphino)benzoic acid Property

Melting point:: 174-181 °C (lit.)
Boiling point:: 159 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 3.72±0.36(Predicted)
form: Powder
color: Light yellow
Stability:: Hygroscopic
InChI: InChI=1S/C19H15O2P/c20-19(21)17-13-7-8-14-18(17)22(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H,20,21)
InChIKey: UYRPRYSDOVYCOU-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC=C1P(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference: 17261-28-8(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 2-(diphenylphosphino)- (17261-28-8)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/22
Safety Statements: 26-36-36/37/39
WGK Germany: 3
RTECS: DG9287500
TSCA: Yes
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 454885
Product name: 2-(Diphenylphosphino)benzoic acid
Purity: 97%
Packaging: 1g
Price: $220
Updated: 2025/07/31

Sigma-Aldrich

Product number: 454885
Product name: 2-(Diphenylphosphino)benzoic acid
Purity: 97%
Packaging: 5g
Price: $535
Updated: 2025/07/31

TCI Chemical

Product number: D3242
Product name: 2-(Diphenylphosphino)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: D3242
Product name: 2-(Diphenylphosphino)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $154
Updated: 2025/07/31

Strem Chemicals

Product number: 15-0133
Product name: 2-(Diphenylphosphino)benzoic acid, min. 97%
Packaging: 1g
Price: $56
Updated: 2024/03/01

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2-(Diphenylphosphino)benzoic acid Chemical Properties,Usage,Production

Chemical Properties

light yellow powder

Uses

2-(Diphenylphosphino)benzoic Acid is used in small molecule control of protein function through staudinger reduction.

Uses

The ligand (R ,R )‐1,2‐Bis(aminocarbonylphenyl‐2′‐diphenylphosphino)cyclohexane[138517-61-0] can be prepared by the coupling of (1R ,2R )‐(-)‐1,2‐diaminocyclohexane [20439-47-8] with 2‐(diphenylphosphino)benzoic acid [17261-28-8], using reagents such as DCC.

An alternative procedure has been developed where by (1R ,2R )‐(+)‐1,2‐diaminocyclohexane L‐tartrate salt [39961-95-0] is coupled to a mixed anhydride of 2‐(diphenylphosphino)benzoic acid and diphenylchlorophosphate.The procedure is reproduced below 2‐(Diphenylphosphino)benzoic acid (20 g, 65.3 mmol, 2 equiv) is suspended in dichloromethane (150 mL) and cooled in an ice‐water bath to 0°C (internal temperature). Triethylamine (10.1 mL, 71.8 mmol, 2.2 equiv) is added dropwise and a clear solution is obtained. This process is exothermic and a rise in temperature to 5°C is observed. The solution is re‐cooled to 0°C and diphenylchlorophosphate (13.4 mL, 64.7 mmol, 1.98 equiv) is added slowly, maintaining the internal temperature between 0–5°C. The yellow solution is stirred for 1 h at 0°C. (1R, 2R )‐(+)‐1,2‐Diaminocyclohexane‐L‐tartrate salt (8.63 g, 32.65 mmol, 1 equiv) is suspended in water (50 mL, 5.8 vol) and potassium carbonate (15 g, 107.8 mmol, 3.3 equiv) is added. This process is exothermic and a clear solution is obtained after approximately 10 min. After 30 min, the clear aqueous solution of diamine is added to the mixed anhydride solution at 0°C, and the resulting yellow two‐phase mixture is stirred for 2 h at 0°C, then allowed to warm to room temperature. After 14 h, the mixture is poured into a separating funnel and 200 mL of dichloromethane and 100 mL of water are added. The organic phase is separated, washed with 2 N HCl (100 mL) and saturated aqueous NaHCO3 solution (100 mL), then dried over magnesium sulfate. The dried organic phase is filtered through a silica pad and the pad is washed with dichloromethane (50 mL). The combined filtrates are evaporated to dryness under reduced pressure, producing a yellow foam (22.3 g, 99% crude). The foam is crystallized from boiling acetonitrile (390 mL, 17.5 vol) to afford a white crystalline solid. The solid is dried under vacuum to provide the phosphine ligand (15 g, 67%).

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling

2-(Diphenylphosphino)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Diphenylphosphino)benzoic acid Suppliers

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View Lastest Price from 2-(Diphenylphosphino)benzoic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(Diphenylphosphino)benzoic Acid 17261-28-8
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-15

Longyan Tianhua Biological Technology Co., Ltd

Product: 2-(Diphenylphosphino)benzoic acid 17261-28-8
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2020-11-10

Career Henan Chemical Co

Product: 2-(Diphenylphosphino)benzoic acid 17261-28-8
Price: US $1.00/KG
Min. Order: 1G
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-12

17261-28-8, 2-(Diphenylphosphino)benzoic acidRelated Search:

3,4'-DIAMINODIPHENYLMETHANE 1,3-Diphenyl-2-thiourea Folic acid tert-Butylchlorodiphenylsilane Chlorodiphenylphosphine Diphenylsilane 1,5-Diphenylcarbazide Diphenylmethane Ascoric Acid Phenyl phosphine 4-(DIPHENYLPHOSPHINO)BENZOIC ACID 2-DIPHENYLPHOSPHINO-1-NAPHTHOIC ACID 1-Methyl-4-(pentafluorophenyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylate 2-(Diphenylphosphino)benzoic acid 2-(Diphenylphosphino)benzoic acid sodium salt AQUANTRAAL RARECHEM FH 1D 0D11 BENZOICACID

2-(DIPHENYLPHOSPHINO)BENZOIC ACID

2-(diphenylphosphino)-benzoicaci

2-Diphenylphosphanyl-benzoicacid

2-Diphenylphosphinobenzoes?ure

2-(DiphenyL

phosphino)benzoic acid

O-(DIPHENYLPHOSPHINO)BENZOIC ACID

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2-(DIPHENYLPHOSPHINO)BENZOIC ACID, MIN. 97%

2-Carboxyphenyldiphenylphosphine

Diphenylphosphinobenzoic acid

2-(Diphenylphosphino)benzoic acid,98%

2-(Diphenylphosphino)benzoic acid, 98% 1GR

2-(Diphenylphosphino)benzoic acid, 98% 5GR

2-Diphenylphosphinobenzoic

2-(Diphenylphosphino)benzoicacid,min.97%

2-(Diphenylphosphino)benzoicacid （DPPBAc）

2-(Diphenylphosphino)benzoic acid ,97%

Benzoic acid, 2-(diphenylphosphino)-

N-trimethylsilyl-2-trimethylsilyloxyethanamine

2-(Diphenylphosphino)benzoic Acid &gt

2-(Diphenylphosphino)benzoic acid, 98%, for synthesis

17261-28-8

7261-28-8

C19H15O2P

C6H52PC6H5COOH

Phosphorus Compounds

Catalysis and Inorganic Chemistry

Phosphine Ligands

TOP1

phosphine ligand

Catalysis and Inorganic Chemistry

Phosphine Ligands

Phosphorus Compounds

Phosphine Ligands

Synthetic Organic Chemistry

Achiral Phosphine

Aryl Phosphine