L-Canavanine
- Product Name
- L-Canavanine
- CAS No.
- 543-38-4
- Chemical Name
- L-Canavanine
- Synonyms
- AI352153;canavanin;AI3 52153;AI3-52153;canavanine;L-CANAVANINE;FSBIGDSBMBYOPN-VKHMYHEASA-N;(L) Canavanine,(L)Canavanine;(+)-O-(Guanidino)-L-homoserine;2-amino-4-(guanidinooxy)butyricacid
- CBNumber
- CB6679318
- Molecular Formula
- C5H12N4O3
- Formula Weight
- 176.17
- MOL File
- 543-38-4.mol
L-Canavanine Property
- Melting point:
- 184°
- alpha
- D20 +7.9° (c = 3.2)
- Boiling point:
- 307.78°C (rough estimate)
- Density
- 1.3685 (rough estimate)
- refractive index
- 1.7900 (estimate)
- storage temp.
- 2-8°C
- solubility
- H2O: <100 mg/mL
- form
- powder
- pka
- pK1: 2.50(+2);pK2: 6.60(+1);pK3: 9.25(0) (25°C)
- PH
- 7.93
- optical activity
- +7.920 (H2O)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22
- Safety Statements
- 36
- WGK Germany
- 3
- RTECS
- ES7002000
- Hazardous Substances Data
- 543-38-4(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- C1625
- Product name
- L-Canavanine
- Purity
- ≥98% (TLC), powder, from Canavalia ensiformis
- Packaging
- 100mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- C1625
- Product name
- L-Canavanine
- Purity
- ≥98% (TLC), powder, from Canavalia ensiformis
- Packaging
- 1g
- Price
- $673
- Updated
- 2024/03/01
- Product number
- C1625
- Product name
- L-Canavanine
- Purity
- ≥98% (TLC), powder, from Canavalia ensiformis
- Packaging
- 250mg
- Price
- $179.2
- Updated
- 2024/03/01
- Product number
- FC162286
- Product name
- L-Canavanine
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- X6876
- Product name
- L-Canavanine
- Packaging
- 250mg
- Price
- $255
- Updated
- 2021/12/16
L-Canavanine Chemical Properties,Usage,Production
Uses
NO synthase inhibitor
Definition
ChEBI: L-canavanine is a non-proteinogenic L-alpha-amino acid that is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group. Although structurally related to L-arginine, it is non-proteinogenic. It has a role as a phytogenic insecticide and a plant metabolite. It is functionally related to a L-homoserine. It is a conjugate base of a L-canavanine(1+). It is a tautomer of a L-canavanine zwitterion.
Biochem/physiol Actions
L-Canavanine is a naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). Overproduction of NO by iNOS plays a crucial role in the pathophysiology of septic shock and chronic inflammation.
Purification Methods
Crystallise S-canavanine from absolute EtOH or aqueous EtOH. [Tomiyama J Biol Chem 111 48 1935 gave pK9.25 (COOH), pK 7.4 (guanidinium), pK 11.5 (NH4+), Gulland & Morris J Chem Soc 763 1935,(±) Frankel et al. J Chem Soc 3127 1963, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2622-2628 1961, Beilstein 4 III 1636, 4 IV 3188.]
L-Canavanine Preparation Products And Raw materials
Raw materials
Preparation Products
L-Canavanine Suppliers
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7887
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 028-85370565-229 18080489829
- 3004654993@qq.com
- Country
- China
- ProdList
- 8861
- Advantage
- 60
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- 18221292452
- fannieliu@glschina.com
- Country
- China
- ProdList
- 6798
- Advantage
- 58