ChemicalBook > CAS DataBase List > PD 168077 MALEATE

PD 168077 MALEATE

Product Name
PD 168077 MALEATE
CAS No.
630117-19-0
Chemical Name
PD 168077 MALEATE
Synonyms
PD 168077 (maL;PD 168077 MALEATE;PD-168077 maleate, 10 mM in DMSO;N-(METHYL-4-(2-CYANOPHENYL)PIPERAZINYL)-3-METHYLBENZAMIDE MALEATE;N-[[4-(2-CYANOPHENYL)-1-PIPERAZINYL]METHYL]-3-METHYL-BENZAMIDE MALEATE;Benzamide,N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-,(2Z)-2-butenedioate(1:1);PD 168077,Dopamine Receptor,PD-168077,inhibit,PD168077,PD168077 maleate,Inhibitor,PD 168077 maleate
CBNumber
CB6679671
Molecular Formula
C24H26N4O5
Formula Weight
450.49
MOL File
Mol file
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PD 168077 MALEATE Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: >10 mg/mL
form 
powder
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05878
Product name
PD 168077 Maleate - CAS 630117-19-0 - Calbiochem
Packaging
10mg
Price
$201
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
50mg
Price
$638
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
25mg
Price
$365
Updated
2024/03/01
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PD 168077 MALEATE Chemical Properties,Usage,Production

Description

PD 168077 is a dopamine D4 receptor agonist (Ki = 8.7 nM in CHO Pro 5 cells expressing the human receptor). It is selective for dopamine D4 over D2 and D3 receptors (Kis = 3,740 and 2,810 nM, respectively), as well as α1- and α2-adrenergic and serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A (Kis = 168, 177, 385, and 4,010 nM, respectively). PD 168077 (20 μM) induces CaMKII translocation from the dendritic shaft to postsynaptic sites on the dendritic processes of primary rat embryonic prefrontal cortex pyramidal neurons, an effect that can be blocked by the IP3 receptor antagonist 2APB or the calcium chelator BAPTA AM . PD 168077 (50-200 ng/animal) induces penile erections in rats when injected into the paraventricular nucleus (PVN) of the hypothalamus. PD 168077 (0.2-25 mg/kg, s.c.) increases spontaneous locomotor activity and reduces grooming and rearing in rats.

Biological Activity

A potent D 4 dopamine receptor agonist (K i = 8.7 nM) with > 400-fold selectivity over D 2 and > 300-fold selectivity versus D 3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .

storage

Store at -20°C

PD 168077 MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 168077 MALEATE Suppliers

China 35 India 1 Japan 1 Switzerland 1 United Kingdom 2 United States 8 USA 1 Global 49
EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
Country
United States
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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United States
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Aladdin Scientific
Tel
+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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57505
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58
TargetMol Chemicals Inc.
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Email
support@targetmol.com
Country
United States
ProdList
38631
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58
ApexBio Technology
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sales@apexbt.com
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United States
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Cayman Chemical Company
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Email
cayman@caymanchem.com
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United States
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6213
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United States Biological
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80

630117-19-0, PD 168077 MALEATERelated Search:


  • N-(METHYL-4-(2-CYANOPHENYL)PIPERAZINYL)-3-METHYLBENZAMIDE MALEATE
  • PD 168077 MALEATE
  • N-[[4-(2-CYANOPHENYL)-1-PIPERAZINYL]METHYL]-3-METHYL-BENZAMIDE MALEATE
  • PD 168077 (maL
  • Benzamide,N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-,(2Z)-2-butenedioate(1:1)
  • PD 168077,Dopamine Receptor,PD-168077,inhibit,PD168077,PD168077 maleate,Inhibitor,PD 168077 maleate
  • PD-168077 maleate, 10 mM in DMSO
  • 630117-19-0
  • 730117-19-0