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3,5-Di-tert-butylbromobenzene

Application
Product Name
3,5-Di-tert-butylbromobenzene
CAS No.
22385-77-9
Chemical Name
3,5-Di-tert-butylbromobenzene
Synonyms
1-BROMO-3,5-DI-TERT-BUTYLBENZENE;1-BROMO-3,5-DI-T-BUTYLBENZENE;TIMTEC-BB SBB005901;3,5- Di TERTbutylbenzene;1-Bromo-3,5-di-tert-butyL;3,5-DI-T-BUTYLBROMOBENZENE;3,5-Di-tert-butylbromobenze;3,5-Di-tert-butylbromobenzene;1-BroMo-3,5-di-tert-butybenzene;1,3-Di-tert-butyl-5-bromobenzene
CBNumber
CB6679949
Molecular Formula
C14H21Br
Formula Weight
269.22
MOL File
22385-77-9.mol
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3,5-Di-tert-butylbromobenzene Property

Melting point:
62-66 °C(lit.)
Boiling point:
152-156 °C(Press: 26 Torr)
Density 
1.126±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
color 
White to Almost white
Water Solubility 
35μg/L at 25℃
BRN 
2091559
InChI
InChI=1S/C14H21Br/c1-13(2,3)10-7-11(14(4,5)6)9-12(15)8-10/h7-9H,1-6H3
InChIKey
BUOWTUULDKULFI-UHFFFAOYSA-N
SMILES
C1(Br)=CC(C(C)(C)C)=CC(C(C)(C)C)=C1
LogP
6.7 at 25℃
CAS DataBase Reference
22385-77-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
592161
Product name
1-Bromo-3,5-di-tert-butylbenzene
Purity
97%
Packaging
1g
Price
$26.91
Updated
2025/07/31
Sigma-Aldrich
Product number
592161
Product name
1-Bromo-3,5-di-tert-butylbenzene
Purity
97%
Packaging
10g
Price
$274
Updated
2025/07/31
TCI Chemical
Product number
B3547
Product name
1-Bromo-3,5-di-tert-butylbenzene
Packaging
5G
Price
$95
Updated
2025/07/31
TCI Chemical
Product number
B3547
Product name
1-Bromo-3,5-di-tert-butylbenzene
Packaging
25G
Price
$286
Updated
2025/07/31
TRC
Product number
B689578
Product name
1-Bromo-3,5-di-t-butylbenzene
Packaging
100mg
Price
$45
Updated
2021/12/16
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3,5-Di-tert-butylbromobenzene Chemical Properties,Usage,Production

Application

3,5-Di-tert-butylbromobenzene can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

Chemical Properties

White solid

Synthesis

1460-02-2

22385-77-9

General procedure for the synthesis of 3,5-di-tert-butylbromobenzene from 1,3,5-tri-tert-butylbenzene: In a dry and argon-flushed 250 mL three-necked round-bottomed flask, a condenser (with nitrogen inlet connector), a thermometer, a dosing funnel, and a magnetic stirring bar coated with Teflon were assembled. Under nitrogen protection, 1,3,5-tri-tert-butylbenzene (15.0 g, 61 mmol, 1.0 eq.) was dissolved in 42 mL of dichloromethane, stirred, and cooled to 0°C. The solution was then purged with an argon flushing syringe. 1.0 mL (7.8 mmol, 0.13 equiv) of antimony pentachloride (SbCl5) was added slowly using an argon-flushed syringe. Liquid bromine (4.94 mL, 96.0 mmol, 1.6 equiv) was dissolved in 20 mL of dichloromethane and transferred to the addition funnel. The entire apparatus was wrapped in aluminum foil to protect it from light. The bromine solution was slowly added dropwise (approximately 1 drop every 2 seconds) over a period of 2 hours. After the dropwise addition, stirring was continued for 3 hours at 0°C. The reaction solution was poured into a mixture of 800 g of ice and 800 mL of water and stirred for 15 minutes. Adjust to pH 8-9 by slowly adding 100 mL of 5 M aqueous sodium hydroxide under stirring. extract the aqueous phase with dichloromethane three times using a 2 L partition funnel. The organic phases were combined and washed sequentially with water, saturated aqueous sodium thiosulfate, water and brine and dried over anhydrous magnesium sulfate. Concentrated by rotary evaporation and dried under vacuum for several hours. The crude product was recrystallized from 30 mL of hot ethanol, heated to boiling and then cooled to room temperature, the solid was collected by filtration and washed three times with minimal amounts of cold ethanol. Vacuum drying gave 11.1 g (68% yield) of 1-bromo-3,5-di-tert-butylbenzene.1H NMR (500 MHz, CDCl3): δ 1.30 (s, 18H), 7.17 (d, 1H), 7.32 (s, 2H). The analytical data are in agreement with literature reports.

References

[1] Chemistry - A European Journal, 2007, vol. 13, # 16, p. 4433 - 4451
[2] Synthetic Communications, 1996, vol. 26, # 9, p. 1693 - 1697
[3] Synlett, 2017, vol. 28, # 13, p. 1548 - 1553
[4] Organic Letters, 2005, vol. 7, # 24, p. 5365 - 5368
[5] Macromolecules, 2002, vol. 35, # 14, p. 5382 - 5387

3,5-Di-tert-butylbromobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Di-tert-butylbromobenzene Suppliers

Americas 1 China 278 Europe 1 Germany 8 India 11 Japan 2 Lithuania 1 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 34 Global 347
Carbosynth
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View Lastest Price from 3,5-Di-tert-butylbromobenzene manufacturers

Zhejiang Free Trade Zone Violet Trade Co., Ltd.
Product
3,5-Di-tert-butylbromobenzene 22385-77-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99.9% HPLC
Supply Ability
10 tons
Release date
2024-03-18
Hebei Chuanghai Biotechnology Co., Ltd
Product
3,5-Di-tert-butylbromobenzene 22385-77-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Henan Aochuang Chemical Co.,Ltd.
Product
3,5-Di-tert-butylbromobenzene 22385-77-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

22385-77-9, 3,5-Di-tert-butylbromobenzeneRelated Search:

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  • 1-Bromo-3,5-di-tert-butyL
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  • 3,5-Di-tert-butylbromobenze
  • 1-BROMO-3,5-DI-TERT-BUTYLBENZENE 99%
  • 1,3-Di-tert-butyl-5-bromobenzene
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  • 5-BroMo-1,3-di-tert-butylbenzene
  • 1-BroMo-3,5-di-tert-butybenzene
  • 1,3-Bis(tert-butyl)-5-bromobenzene
  • 3,5- Di TERTbutylbenzene
  • 1-Bromo-3,5-di-<i>tert</i>-butylbenzene
  • 1-Bromo-3,5-di-tert-butylbenzene≥ 99%(GC)
  • Benzene,1-bromo-3,5-bis(1,1-dimethylethyl)-
  • 1-Bromo-3,5-di-tert-butylbenzene, 99% white crystalline solid
  • 1-bromo-3,5-di-tert-butylbenzene, 3,5-di-tert-Bu-bromobenzene, 3,5-tert-butyl bromobenzene, bromo-3,5-di-t-butylbenzene, 1-bromo-3,5-di(tert-butyl)benzene, 1-bromo-3,5-di-tert-butyl benzene, 3,5-di-tert-butyl-1-bromobenzene
  • 5-Bromo-1,3-di-tert-butylbenzene/1-Bromo-3,5-di-tert-butylbenzene
  • 3,5-Bis(tert-butyl)-1-bromo-benzene
  • 1-Bromo-3,5-di-tert-butylbenzene &gt
  • 3,5-Di-tert-butylbromobenzene ISO 9001：2015 REACH
  • 3, 5-Di-Tert-Butylbromobenzene CAS 22385-77-9
  • 1-Bromo-3,5-bis(1,1-dimethylethyl)benzene
  • 3,5-Di-tert-butylbromobenzene 98+
  • 22385-77-9
  • BrC6H3CCH332
  • ARYL HALIDE
  • Organic Building Blocks
  • Halogenated Hydrocarbons
  • Building Blocks
  • C13 to C37+
  • Aryl
  • Aryl
  • C13 to C37+
  • Halogenated Hydrocarbons